Cabazitaxel - CAS 183133-96-2
Catalog number:
B0084-461977
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C45H57NO14
Molecular Weight:
835.93
COA:
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Targets:
Microtubule/Tubulin
Description:
Cabazitaxel increases CYP3A enzyme activities in rat hepatocytes. The mean ex-vivo human plasma protein binding of Cabazitaxel is 91.6%.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-461977 500 mg $298 In stock
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Purity:
>98%
Synonyms:
RPR-116258A, XRP6258, TXD 258
MSDS:
Inquire
1.Clarification to provide further understanding of the conduct and design of TROPIC: A Phase 3 trial of cabazitaxel versus mitoxantrone in patients with metastatic castration-resistant prostate cancer.
De Bono J1, Shen L, Sartor O. Arch Ital Urol Androl. 2016 Mar 31;88(1):72-73. doi: 10.4081/aiua.2016.1.72.
Not available.
2.Reply to: Clarification to provide further understanding of the conduct and design of TROPIC: A Phase 3 trial of cabazitaxel versus mitoxantrone in patients with metastatic castration-resistant prostate cancer.
Perletti G1. Arch Ital Urol Androl. 2016 Mar 31;88(1):74-75. doi: 10.4081/aiua.2016.1.74.
Not available.
3.Redox-Sensitive Citronellol-Cabazitaxel Conjugate: Maintained in Vitro Cytotoxicity and Self-Assembled as Multifunctional Nanomedicine.
Xue P1, Liu D1, Wang J1, Zhang N1, Zhou J1, Li L1, Guo W1, Sun M1, Han X1, Wang Y1. Bioconjug Chem. 2016 Apr 20. [Epub ahead of print]
Citronellol-cabazitaxel (CIT-ss-CTX) conjugate self-assembled nanoparticles (CSNPs) were designed and prepared by conjugating cabazitaxel with citronellol via the disulfide bond that is redox-sensitive to the high concentration of glutathione within tumor cells. Notably, the CSNPs maintained in the cell cytotoxicity. Moreover, the AUC0-t of CSNPs was 6.5-fold higher than that of cabazitaxel solutions and the t1/2 was prolonged 2.3 times. Furthermore, we found that CSNPs could be employed as an efficient carrier for other hydrophobic drugs or imaging agents. Thus, the in vivo targeting study was implemented via using 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR)-loaded CSNPs as imaging agent, which showed CSNPs could effectively accumulate at the tumor site. Curcumin, a hydrophobic anticancer drug, was successfully loaded in CSNPs which exhibits good stability and synergistic antitumor effects. The citronellol-cabazitaxel conjugate therefore has a promising perspective as a multifunctional nanomedicine for combination therapy and theranostics attributed to its long-circulation property, redox-sensitive mechanism, and high drug coloading capability.
4.Effectiveness and safety of cabazitaxel chemotherapy for metastatic castration-resistant prostatic carcinoma on Turkish patients (The Anatolian Society of Medical Oncology).
Süner A1, Aydın D, Hacıoğlu MB, Doğu GG, İmamoğlu GI, Menekşe S, Pilancı KN, Yazıcı ÖK, Koca D, Karaağaç M, Akyol M, Akman T, Ergen S, Avcı N, Kaçan T, Bozkurt O, Kefeli U, Urakçı Z, Araz M, Arpacı E, Harputlu H, Sevinç A. Eur Rev Med Pharmacol Sci. 2016 Apr;20(7):1238-43.
OBJECTIVE: Prostate cancer is among the most common cancers in males. Prostate cancer is androgen dependent in the beginning, but as time progresses, it becomes refractory to androgen deprivation treatment. At this stage, docetaxel has been used as standard treatment for years. Cabazitaxel has become the first chemotherapeutic agent which has been shown to increase survival for patients with metastatic Castrate Resistant Prostate Cancer (mCRPC) that progresses after docetaxel. Phase 3 TROPIC study demonstrated that cabazitaxel prolongs survival.
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CAS 183133-96-2 Cabazitaxel

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