|Description||C-1311 is a Fms-like tyrosine kinase 3 inhibitor under the development of Antisoma. It has shown activity in experimental tumour models both in vitro and in nude mice. C-1311 can delay progression of cells through the S phase which was followed by G2 arrest at the EC(99) dose as a mitosis inhibitor. Phase I clinical trials for treatment of solid tumours and a phase II clinical trials for the treatment of breast cancer were discontinued.|
|Synonyms||Imidacrine; XLS-002; C-1311 dihydrochloride; XLS 002; C 1311 dihydrochloride; XLS002; C1311 dihydrochloride; Symadex; Imidazoacridinone; CHEMBL3545337;5-(2-(diethylamino)ethylamino)--8-hydroxy-6H-imidazo(4,5,1-de)acridin-6-one|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
Ono 3403, a derivative of camostat mesilate and has a higher protease-inhibitory activity, is a synthetic serine protease inhibitor that inhibits lipopolysaccha...
This active molecular is a highly selective neutrophil elastase inhibitor .IC50 for HNE is 0.065 nM, LipE is 7.2. BAY 85-8501 was being tested in clinical studi...
DW532 is one of simplified analogues of hematoxylin that has been reported to have a broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer acti...
Gabexate is a serine protease inhibitor that inhibits trypsin (IC50= 9.4μM), plasmin (IC50= 30μM), plasma kallikrein (IC50= 41μM) and thrombin (IC50= 110μM). It...
C-1311 is a Fms-like tyrosine kinase 3 inhibitor under the development of Antisoma. It has shown activity in experimental tumour models both in vitro and in nud...
TAK-659 is a potent spleen tyrosine kinase (syk) inhibitor under the development of Takeda Oncology, with potential anti-inflammatory, immunomodulating, and ant...
CFI-401870 is a TTK (tyrosine threonine kinase) Inhibitor with IC50 value < 10 nM. CFI-401870 showed low off-target activity (>500×) and microsomal stability (T...
Nafamostat is a broad spectrum serine protease inhibitor and kallikrein inhibitor. It inhibits blood coagulation and used as an anticoagulant. It is also a poss...