|Description||C-1311 is a Fms-like tyrosine kinase 3 inhibitor under the development of Antisoma. It has shown activity in experimental tumour models both in vitro and in nude mice. C-1311 can delay progression of cells through the S phase which was followed by G2 arrest at the EC(99) dose as a mitosis inhibitor. Phase I clinical trials for treatment of solid tumours and a phase II clinical trials for the treatment of breast cancer were discontinued.|
|Synonyms||Imidacrine; XLS-002; Symadex; Imidazoacridinone; CHEMBL3545337;5-(2-(diethylamino)ethylamino)--8-hydroxy-6H-imidazo(4,5,1-de)acridin-6-one|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
A potent inhibitor of dipeptidyl peptidase IV (DPP-IV)
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