BX-517 - CAS 850717-64-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H14N4O2
Molecular Weight:
282.3
COA:
Inquire
Targets:
PDK-1
Description:
BX-517, also known as PDK1 inhibitor2, is a cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDK1 inhibitor (IC50 = 6 nM). BX-517 also blocks activation of Akt in tumor cells with 10-fold more potent (IC50 = 0.1–1.0 μM) than its analogs tested at the highest dose tested (10 μM).
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Appearance:
Solid powder
Synonyms:
(Z)-N-(3-(1-(1H-pyrrol-2-yl)ethylidene)-2-hydroxy-3H-indol-5-yl)carbamimidic acid; BX-517; BX 517; BX517; PDK1 inhibitor2.
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
572.4±50.0 °C at 760 Torr
Density:
1.430±0.06 g/cm3
InChIKey:
DFURSNCTQGJRRX-JYRVWZFOSA-N
InChI:
1S/C15H14N4O2/c1-8(11-3-2-6-17-11)13-10-7-9(18-15(16)21)4-5-12(10)19-14(13)20/h2-7,17H,1H3,(H,19,20)(H3,16,18,21)/b13-8-
Canonical SMILES:
OC(NC1=CC2=C(N=C(O)/C2=C(C3=CC=CN3)/C)C=C1)=N
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Chemical Structure

CAS 850717-64-5 BX-517

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