Butylphthalide (Natural) - CAS 6066-49-5
Catalog number: 6066-49-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Butylphthalide is an anti-cerebral-ischemia drug, which is first isolated from the seeds of celery, showed efficacy in animal models of stroke. It alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits.
Publictions citing BOC Sciences Products
  • >> More
3-n-Butylphthalide; 3-Butylphthalide
1.[Correlation Analysis Between Common Peaks of Angelica sinensis HPLC Fingerprint and Mineral Elements in Its Growing Soil].
Ding JX, Gu ZR, Wang YL, Zhang YY, Wang YP, Sun YJ. Zhong Yao Cai. 2015 Aug;38(8):1595-9.
OBJECTIVE: To investigate the correlation between common peaks of Angelica sinensis HPLC fingerprint and mineral elements in its growing soil.
2.Dl-3-n-butylphthalide-induced upregulation of antioxidant defense is involved in the enhancement of cross talk between CREB and Nrf2 in an Alzheimer's disease mouse model.
Wang CY1, Wang ZY2, Xie JW3, Wang T2, Wang X4, Xu Y5, Cai JH6. Neurobiol Aging. 2016 Feb;38:32-46. doi: 10.1016/j.neurobiolaging.2015.10.024. Epub 2015 Nov 2.
Synapse impairment in the Alzheimer's disease (AD) brain is an early event leading to cognitive dysfunction. Most oxidative stress localizes to the synapse, and synapse loss is the basis of cognitive decline in AD. Dl-3-n-butylphthalide (Dl-NBP), a small molecule compound has been shown to ameliorate oxidative stress. We evaluated the effects of a 5-month oral delivery with Dl-NBP on oxidative stress and cognitive function in APP/PS1 transgenic mice. Dl-NBP treatment reduced oxidative stress in the APP/PS1 mouse brain and alleviated learning and memory deficits. Dl-NBP supplementation meliorated synaptic plasticity, diminished soluble amyloid beta and amyloid beta oligomer in the APP/PS1 mouse brain. Dl-NBP administration caused an increase of cyclic adenosine monophosphate-response element binding protein (CREB)-binding protein (CBP)-associated Ser133-phosphorylated CREB (p-CREB) protein. Chromatin immunoprecipitation analysis revealed that Dl-NBP increased the recruitment of CBP to the promoters of best-characterized genes downstream of nuclear factor erythroid 2-related factor 2, nicotinamide adenine dinucleotide phosphate (NADPH) quinone oxidoreductase 1, and γ-glutamylcysteine synthetase modifier subunit.
3.Synthesis and biological evaluation of n-butylphthalide derivatives as anti-platelet aggregation agents.
Chen M1,2, Liu Q3, Tan M4, Wen S5, Pi R3, Lin D1,2. Nat Prod Res. 2016 Feb 15:1-4. [Epub ahead of print]
New analogues of n-butylphthalide (NBP) bearing various lengths of alkyl and different substitution at the two-position of phthalide were designed and synthesised. Preliminary evaluation and prediction of ACD LogP software indicate that the derivatives display significant improvement in water solubility than NBP does. Further biological analysis showed that NBP analogues specifically inhibit platelet aggregation induced by arachidonic acid but have no effect on that induced by adenosine 5-diphosphate. Especially compounds 1 and 3 were stronger than classical anti-platelet drug, aspirin, and equal potent with NBP, respectively. These findings provide an alternative approach to the development of NBP analogues with anti-platelet aggregation activity with good water solubility for the intervention of ischemic stroke.
4.Butylphthalide Suppresses Neuronal Cells Apoptosis and Inhibits JNK-Caspase3 Signaling Pathway After Brain Ischemia /Reperfusion in Rats.
Wen XR1,2, Tang M1,3, Qi DS1,4, Huang XJ5, Liu HZ1, Zhang F1, Wu J1, Wang YW5, Zhang XB5, Guo JQ6, Wang SL7, Liu Y1, Wang YL3, Song YJ8,9. Cell Mol Neurobiol. 2016 Mar 25. [Epub ahead of print]
Although Butylphthalide (BP) has protective effects that reduce ischemia-induced brain damage and neuronal cell death, little is known about the precise mechanisms occurring during cerebral ischemia/reperfusion (I/R). Therefore, the aim of this study was to investigate the neuroprotective mechanisms of BP against ischemic brain injury induced by cerebral I/R through inhibition of the c-Jun N-terminal kinase (JNK)-Caspase3 signaling pathway. BP in distilled non-genetically modified Soybean oil was administered intragastrically three times a day at a dosage of 15 mg/(kg day) beginning at 20 min after I/R in Sprague-Dawley rats. Immunohistochemical staining and Western blotting were performed to examine the expression of related proteins, and TUNEL-staining was used to detect the percentage of neuronal apoptosis in the hippocampal CA1 region. The results showed that BP could significantly protect neurons against cerebral I/R-induced damage.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CAS 119348-12-8 5α-reductase-IN-1

(CAS: 119348-12-8)

An inhibitor of 5α-reductase

CAS 284040-76-2 Ac9-25

(CAS: 284040-76-2)

Ac9-25 is a N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. It stimulates neutrophil NADPH oxidase activation by acting...

CAS 123-82-0 2-Aminoheptane

(CAS: 123-82-0)

2-Aminoheptane, a fatty Amine compound, is commonly used in proteomics research and could also be used to product some A3 adenosine receptor antagonists.

CAS 612530-44-6 PTP1B-IN-1

(CAS: 612530-44-6)

PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor.

(CAS: 1338793-07-9)

CFI-400936 is a selective proteine kinase TTK inhibitor with IC50 value of 3.6nM. It demonstrates good activity in cell based assay and selectivity against a pa...

CGP 55802A
(CAS: 152564-63-1)

CGP 55802A has been found to be a photoaffinity ligand that could be used to label NMDA receptor and have high selectivity to glutamate recognition site.

(CAS: 202822-21-7)

CAS 19666-76-3 Panaxadiol

(CAS: 19666-76-3)

Panaxadiol, a triterpenoid compound extracted from roots of Panax ginseng C, a novel antitumor agent that regulates of cell cycle transition and induces apoptot...

CAS 7492-32-2 Isopropamide

(CAS: 7492-32-2)

Isopropamide is a long-acting anticholinergic drug. It can be used for the treatment of peptic ulcers and other gastrointestinal disorders including hyperacidit...

CAS 7292-81-1 (RS)-4-Carboxyphenylglycine

(CAS: 7292-81-1)

(RS)-4-Carboxyphenylglycine has been found to be a broad spectrum EAA ligand.

CAS 1430213-30-1 ML216

(CAS: 1430213-30-1)

Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM...

CAS 50-99-7 Dextrose

(CAS: 50-99-7)

Dextrose, a simple sugar (monosaccharide), is an important carbohydrate in biology.

CAS 504-03-0 Nanofin

(CAS: 504-03-0)

Nanofin is neuropathic blocker used for mild to moderate hypertension.

CAS 82186-77-4 Benflumetol

(CAS: 82186-77-4)

Benflumetol, also known as HSDB 7210, is an antimalarial drug used to treat acute uncomplicated malaria. It is used in combination with Artemether for improved ...

CAS 56211-40-6 Torsemide

(CAS: 56211-40-6)

Torsemide is a pyridine-sulfonyl urea type loop diuretic with an IC50 of 2.7 ± 0.17 μM.

CAS 100929-71-3 β-NADPH tetra (cyclohexylammonium) salt

β-NADPH tetra (cyclohexylammonium) salt
(CAS: 100929-71-3)

β-NADPH tetra(cyclohexylammonium), generating in vivio by the pentose phosphate pathway, is a a ubiquitous cofactor and biological reducing agent.

CAS 141400-58-0 PX-12

(CAS: 141400-58-0)

PX-12 is an irreversible inhibitor of Trx-1 currently in clinical development as an antitumor agent. The research results suggest that the lowering of elevated ...

(CAS: 312951-85-2)

PROTO-1, a benzothiophene carboxamide, shows significant protection of hair cells over a broad range of neomycin concentrations, from 25 μM to 400 μM.

CAS 1218942-37-0 GKT137831

(CAS: 1218942-37-0)

GKT137831 attenuates hypoxia-induced H(2)O(2) release, cell proliferation, and TGF-β1 expression and blunted reductions in PPARγ in HPAECs and HPASMCs.

CAS 1579991-61-9 Chitinase-IN-1

(CAS: 1579991-61-9)

Chitinase-IN-1 is a insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide; 50 uM/20uM compound concentration's inhibitory percentage are 75%...

Chemical Structure

CAS 6066-49-5 Butylphthalide (Natural)

Quick Inquiry

Verification code

Featured Items