Butoconazole nitrate - CAS 64872-77-1
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Butoconazole nitrate is an anti-fungal agent for IL-2, TNFα, IFN and GM-CSF with IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively.
Publictions citing BOC Sciences Products
  • >> More
1.[Treatment in cases of recurrent vaginal candida infection during pregnancy].
Nikolov A, Shopova E, Mikhova M, Dimitrov A. Akush Ginekol (Sofiia). 2007;46(9):23-6.
OBJECTIVE: To study the therapeutic application of Gynazol in cases of recurrent vaginal Candida infections during the last trimester of pregnancy.
2.Anti-inflammatory and anti-itch activity of sertaconazole nitrate.
Liebel F1, Lyte P, Garay M, Babad J, Southall MD. Arch Dermatol Res. 2006 Sep;298(4):191-9. Epub 2006 Jul 26.
Cutaneous fungal infections are frequently associated with an inflammatory component including irritated skin, itching and stinging/burning. Therapeutic anti-fungal agents that have anti-inflammatory activity have the potential to provide clinical benefit beyond fungus eradication. Recently, certain anti-fungal agents have been shown to have intrinsic anti-inflammatory activity, therefore we sought to determine the extent of the anti-inflammatory activity of these compounds. The anti-inflammatory activities of eight anti-fungal agents (butoconazole, ciclopirox olamine, fluconazole, miconazole nitrate, sertaconazole nitrate, terconazole, tioconazole and ketoconazole) were compared in a number of preclinical models of dermal inflammation and pruritus. While butoconazole, ciclopirox olamine, fluconazole, and miconazole nitrate were all found to have anti-inflammatory activity, only sertaconazole nitrate reduced the release of cytokines from activated lymphocytes and mitigated inflammation in animal models of irritant contact dermatitis and neurogenic inflammation.
3.Treatment of recurrent vulvo-vaginal candidiasis with sustained-released butoconazole pessary.
Heng LZ1, Chen Y, Tan TC. Singapore Med J. 2012 Dec;53(12):e269-71.
Vulvo-vaginal candidiasis (VVC) is a common infection among women. 5% of women with acute infection experience recurrent vulvo-vaginal candidiasis (RVVC). There is currently no optimal or recommended regime for RVVC. Although antifungal agents, such as imidazoles, have been successfully used as a first-line treatment for acute VVC, its effectiveness is limited in RVVC. This could be due to patient factors, drug application (such as leakage) or dosing factors. A sustained-release (SR) bioadhesive vaginal cream (2% butoconazole nitrate) has incorporated VagiSite technology, a topical drug delivery system that allows SR of the drug. We describe its efficacy and the successful use of a butoconazole-SR formulation in the treatment of two cases of RVVC.
4.Advancing vaginal drug delivery.
Merabet J1, Thompson D, Saul Levinson R. Expert Opin Drug Deliv. 2005 Jul;2(4):769-77.
Bacterial vaginosis and vulvovaginal candidiasis are the two most common forms of vaginitis in female patients. Although a variety of effective treatments have been available to eradicate these infections, limitations have lessened the utility of previously available products. Oral therapies are often fraught with systemic adverse reactions, as well as the potential to interact with concomitant medications. Vaginal preparations, although generally perceived as safer, have historically been undesirable for women to use due to their multiple days of dosing; messy, dripping creams; and requisite night-time dosing. Recognising that the therapeutic delivery of the active agent plays a critical role in the overall success of therapy, and attempting to circumvent the weaknesses of traditional vaginal drug delivery while maintaining and even improving safety profiles, a new form of vaginal drug delivery was developed. This unique and proprietary delivery system, with both bioadhesive and sustained release properties, introduces the convenience of a single dose of medication that can be applied at any time, with efficacy rates equivalent to lengthier durations of treatment.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antifungal Products

CAS 104987-12-4 Ascomycin (FK520)

Ascomycin (FK520)
(CAS: 104987-12-4)

Ascomycin, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte.

CAS 137234-62-9 Voriconazole

(CAS: 137234-62-9)

Voriconazole inhibits 95% of isolates at ≤1 μg/ml against 448 recent clinical mold isolates

CAS 38083-17-9 Climbazole

(CAS: 38083-17-9)

Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. Climbazole has shown a high...

CAS 235114-32-6 Micafungin

(CAS: 235114-32-6)

In a mouse model of septic A. fumigatus infection, although non-treated mice survived for a maximum of only 6 days, the survival rate of micafungin-treated mice...

CAS 155347-36-7 Fluconazole hydrate

Fluconazole hydrate
(CAS: 155347-36-7)

Fluconazole (hydrate) is the hydrate salt form of fluconazole, which is a triazole antifungal intended for oral treatment of superficial and systemic mycoses. I...

CAS 2022-85-7 Flucytosine

(CAS: 2022-85-7)

The combination of Flucytosine and IgGl monoclonal antibody to Cryptococcus neoformans capsular glucuronoxylomannan is more effective in reducing the numbers of...

CAS 7716-60-1 Etisazole

(CAS: 7716-60-1)

Etoxazole is a narrow spectrum systemic acaricide used to combat spider mites.

CAS 65899-73-2 Tioconazole

(CAS: 65899-73-2)

Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by a fungus or yeast, with an average IC50 of 1.7 μM.

CAS 78628-80-5 Terbinafine HCl

Terbinafine HCl
(CAS: 78628-80-5)

Terbinafine HCl is a hydrochloride salt of terbinafine that is a synthetic allylamine antifungal and a squalene epoxidase inhibitor with an IC50 of 30 nM for Ca...

CAS 130000-40-7 Thifluzamide

(CAS: 130000-40-7)

Thifluzamide, a highly potent fungicide, could be commonly used in potatoes and rice against basidiomycete fungi.

CAS 126-07-8 Griseofulvin

(CAS: 126-07-8)

Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function.

CAS 241479-67-4 Isavuconazole

(CAS: 241479-67-4)

Isavuconazole is a new triazole currently undergoing phase III clinical trials. This compound has shown in vitro activity against a large number of clinical imp...

CAS 65473-14-5 Naftifine HCl

Naftifine HCl
(CAS: 65473-14-5)

Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis, probably involves selectively blocking st...

CAS 141-94-6 Hexetidine

(CAS: 141-94-6)

Hexetidine, mixture of stereoisomers, is an antibacterial and antifungal agent that destroy fungi by suppressing their ability to grow or reproduce.

CAS 73151-29-8 Fenticonazole Nitrate

Fenticonazole Nitrate
(CAS: 73151-29-8)

Fenticonazole Nitrate is an azole antifungal agent.

CAS 179463-17-3 Caspofungin Acetate

Caspofungin Acetate
(CAS: 179463-17-3)

Caspofungin acetate is the first in a new class of antifungals that inhibits the synthesis of beta (1, 3)-d-glucan, an essential component of the cell wall of f...

CAS 208538-73-2 Micafungin Sodium

Micafungin Sodium
(CAS: 208538-73-2)

Micafungin Sodium is an inhibitor of 1, 3-beta-D-glucan synthesis, used as an antifungal drug.

CAS 166663-25-8 Anidulafungin

(CAS: 166663-25-8)

Anidulafungin, is a semisynthetic echinocandin that inhibits glucan synthase, an enzyme important in the formation of (1→3)-β-D-glucan, a major fungal cell wall...

CAS 135575-42-7 Pneumocandin B0

Pneumocandin B0
(CAS: 135575-42-7)

Pneumocandin B0, also called as L 688786, is an inhibitor of ß-(1,3)-D-glucan (a component of fungal cell walls) synthesis with an antifungal effect (IC50s = 70...

CAS 88678-31-3 Liranaftate

(CAS: 88678-31-3)

Liranaftate is a squalene epoxidase inhibitor exhabing anti-fungicidal activities.

Chemical Structure

CAS 64872-77-1 Butoconazole nitrate

Quick Inquiry

Verification code

Featured Items