Bupivacaine HCl - CAS 18010-40-7
Catalog number:
18010-40-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H28N2O.HCl
Molecular Weight:
324.89
COA:
Inquire
Targets:
Others
Description:
Bupivacaine HCl binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
MSDS:
Inquire
1. Solid-state NMR studies of pharmaceutical solids in polymer matrices
Joseph W. Lubach • Brian E. Padden • Stephanie L. Winslow • Jonathon S. Salsbury. Anal Bioanal Chem (2004) 378 : 1504–1510
The multiple polymorphic and pseudopolymorphic forms of bupivacaine-HCl that can be generated upon heating or recrystallization are shown in Fig. 3. If bupivacaine HCl is heated at 100 °C for 12 h, the material becomes disordered, as indicated by the increase in the breadth of the lines in the NMR spectrum. However, the material does not become amorphous. Further heating to 170 °C for 12 h produces yet a different spectrum. This spectrum could be composed of either a mixture of two different forms, or there could be two different crystallographically non-equivalent sites in the unit cell. Yet another form can be generated by recrystallization from ethanol. There is a strong possibility that this is an ethanol solvate, as there is a peak at ~60 ppm that is characteristic of ethanol.
2. Different anesthetic agents-soaked sinus packings on pain management after functional endoscopic sinus surgery: which is the most effective?
Suheyl Haytoglu • Gokhan Kuran • Nuray Bayar Muluk • Osman Kursat Arıkan. Eur Arch Otorhinolaryngol (2016) 273:1769–1777
In the present study, we investigated the efficacy of local anesthetics soaked merocel sinus packs after FESS. Topical anesthetics are classified in two groups, amide and ester derivates. Lidocaine, Bupivacaine, Ropivacaine and Prilocaine are the amide group of topical anesthetic. In 5 groups, 2% lidocaine HCl, 0.25 % Bupivacaine HCl, 0.2 % Ropivacaine, 2 % Prilocaine and 0.9 % NaCl (Saline) were applied, respectively. In our study, preoperative Lund–Mackay CT Score values of the groups were not different. There was no significant difference between bleeding grade of the groups. In Bupivacaine group, number of gauze/24 h use was lower than lidocaine, ropivacaine and prilocaine groups. In saline group, number of gauze/24 h use was higher than lidocaine, ropivacaine and prilocaine groups.
3. The effect of bupivacaine•HCl on the physical properties of neuronal membranes
K. I. Koo & J. H. Bae & C. H. Lee & C. D. Yoon & J. H. Pyun & S. H. Shin & Y. C. Jeon & M. K. Bae. Protoplasma (2008) 234:3–12
Figure 5 shows that the anisotropy (r) of DPH in the TNBS untreated membrane (inner plus outer monolayers) decreased gradually (fluidization) with increasing bupivacaine HCl concentrations (Fig. 5, filled squares). There was a similar, but more gradual, decrease in the calculated anisotropy of the inner monolayer at any bupivacaine•HCl concentration (Fig. 5, filled triangles). The anisotropy of DPH in SPMVs inner monolayer incubated with 1 mM bupivacaine HCl was 0.182±0.005** (n=5, P<0.01), and the change in anisotropy value before and after adding 1 mM bupivacaine•HCl was 0.038. The values in the inner monolayer were 0.220±0.003 (n=5) and 0.269±0.005 (n=5) at 37°C and 25°C, respectively. Thus the effect of 1 mM bupivacaine HCl was equivalent to that produced by a temperature increase of approximate 9.3°C. However, there was no statistically significant decrease in the anisotropy (the rotational mobility range) of the outer monolayer at 0.01∼0.02 mM of the bupivacaine•HCl concentrations used. These results suggest that the fluidizing effect (range of rotational mobility) of bupivacaine•HCl is selective.
4. Controlled release of bupivacaine HCl through microchannels of biodegradable drug delivery device
Kang Ju Lee & Sung Yeun Yang & WonHyoung Ryu. Biomed Microdevices (2012) 14:583–593
Release of bupivacaine HCl in deionized water and phosphate buffered saline solution To assess the effect of release media, microfluidic devices containing BHCl were tested in both deionized water (DI water) and phosphate buffered saline (PBS) solutions. Two groups of devices were fabricated to have the channel lengths of 0.7 mm and one group of devices had the release channels of 1.6 mm. The amount of bupivacaine loaded in each device (2.4 mg/device on average)was determined such that the solubility limit of the analgesic was maintained over three days. Under this condition, diffusional transport of BHCl was expected to be at a constant rate for at least three days. As shown in Fig. 4, when devices with 0.7 mm long channels were placed in DI water, BHCl was released at a constant rate close to the estimated value from Table 1. However, devices with the same channel lengths (0.7 mm) was tested in a PBS solution, the release profile showed biphasic patterns. Until day one, it showed zero-order release almost identical to the devices in DI water.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 121-32-4 Ethyl vanillin

Ethyl vanillin
(CAS: 121-32-4)

Ethyl vanillin, a kind of flavorant, could be commonly used in the production of food like chocolate. FEMA No: 2464.

Dirlotapide
(CAS: 481658-94-0)

Dirlotapide is a drug used to treat obesity in dogs works as a gut-selective microsomal triglyceride transfer protein (MTTP or MTP) inhibitor.

CAS 69363-14-0 Schisanhenol

Schisanhenol
(CAS: 69363-14-0)

Schisanhenol, isolated from Schisandra rubriflora, has antioxidative effect on human LDL oxidation. The mechanism of Schisanhenol against LDL oxidation may be t...

N-desmethyl Netupitant
(CAS: 290296-72-9)

N-desmethyl Netupitant is a metabolite of an antiemitic drug called Netupitant.

CAS 163222-33-1 Ezetimibe

Ezetimibe
(CAS: 163222-33-1)

Ezetimibe produces a significant reduction in total cholesterol, LDL cholesterol, and triglycerides as well as a small but significant increase in HDL cholester...

CAS 606-04-2 Pamabrom

Pamabrom
(CAS: 606-04-2)

Pamabron is a common over-the-counter diuretic used for relief of menstrual-associated symptoms. It is available in combination with acetaminophen for various c...

AR12463
(CAS: 100557-04-8)

AR12456 is a trapidil derivative. It protects against serum hyperlipidemia in guinea pigs. It has a strong antilipidemic action in guinea pigs fed a cholesterol...

CAS 2167-85-3 Pipazetate

Pipazetate
(CAS: 2167-85-3)

Pipazetate, as a cough suppressant, is a non-narcotic oral antitussive agent acting centrally on the medullary cough center.

CAS 328232-95-7 MK 0557

MK 0557
(CAS: 328232-95-7)

MK-0557 is a highly selective, orally administered neuropeptide NPY5R antagonist, could limit weight regain after very-low-calorie diet (VLCD)-induced weight lo...

CAS 475203-77-1 Mebeverine Acid

Mebeverine Acid
(CAS: 475203-77-1)

Mebeverine Acid is a metabolite of Mebeverine, an antispasmodic. Mebeverine acid appears to be a valuable marker of oral exposure to Mebeverine.

CAS 172922-91-7 FICZ

FICZ
(CAS: 172922-91-7)

High affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 p M). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A...

CAS 505-44-2 Iberin

Iberin
(CAS: 505-44-2)

Iberin, a naturally occurring member of isothiocyanate family found in cruciferous plants, inhibits cell survival (IC50= 2.3 μM in HL60 cell).

CAS 67330-25-0 Ufenamate

Ufenamate
(CAS: 67330-25-0)

Ufenamate is a topical analgesic.

CAS 94-26-8 Butylparaben

Butylparaben
(CAS: 94-26-8)

Butylparaben is used as an antimicrobial preservative in cosmetics. It is also used in medication suspensions and used as a flavoring additive in food.

NC 174
(CAS: 138460-25-0)

NC-174 is a trisubstituted guanidine high potency synthetic sweetener.

CAS 86541-74-4 Benazepril HCl

Benazepril HCl
(CAS: 86541-74-4)

Benazepril is a drug of the angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure.

CAS 606-68-8 NADH (disodium salt)

NADH (disodium salt)
(CAS: 606-68-8)

NADH becomes oxidized to produce NAD+, NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen donor in the respiratory chain.

CAS 27050-41-5 Clenpirin

Clenpirin
(CAS: 27050-41-5)

Clenpirin, an imino-pyrolidine, has been developed as an acaricide for the control of Boophilus.

CAS 59-46-1 Procaine

Procaine
(CAS: 59-46-1)

Procaine is a local anesthetic drug of the amino ester group, which acts through multiple targets.

CAS 6106-24-7 Disodium tartrate dihydrate

Disodium tartrate dihydrate
(CAS: 6106-24-7)

Disodium tartrate dihydrate is a Acid phosphatase inhibitor used in buffers for molecular biology and cell culture applications.

Chemical Structure

CAS 18010-40-7 Bupivacaine HCl

Quick Inquiry

Verification code

Featured Items