Budesonide - CAS 51333-22-3
Catalog number: 51333-22-3
Category: Inhibitor
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Molecular Formula:
C25H34O6
Molecular Weight:
430.541
COA:
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Targets:
Glucocorticoid Receptor
Description:
Budesonide is a glucocorticoid steroid that activates the glucorcorticoid receptor with an EC50 value of 12.4 nM. Like other glucocorticoids, budesonide reduces inflammation and has utility in inflammatory diseases, like asthma and inflammatory bowel disease. Also like other glucocorticoids, budesonide may be abused by athletes.
Purity:
0.98
Appearance:
white to off-white solid
Synonyms:
Rhinocort, Rhinosol, Pulmicort, Budicort, Entocort, Symbicort, Noex, Entocort EC.
MSDS:
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InChIKey:
VOVIALXJUBGFJZ-WZTTZPBOSA-N
InChI:
InChI=1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17?,18-,20?,21?,22?,23-,24-,25?/m0/s1
Canonical SMILES:
CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C
1.Acupuncture for moderate to severe allergic rhinitis: A non-randomized controlled trial.
Chen YD1,2, Jin XQ3, Yu MH1, Fang Y2, Huang LQ4. Chin J Integr Med. 2016 Mar 21. [Epub ahead of print]
OBJECTIVE: To evaluate the effect and safety of acupuncture therapy on patients with moderate to severe allergic rhinitis.
2.[Efficacy of fluticasone propionate aerosol versus budesonide suspension in treatment of recurrent wheezing caused by bronchiolitis].
Lan WP1, Wang J, Dai CL, Pan JH. Zhongguo Dang Dai Er Ke Za Zhi. 2016 Apr;18(4):316-9.
OBJECTIVE: To investigate the efficacy of fluticasone propionate aerosol (flixotide) versus budesonide suspension in the treatment of recurrent wheezing caused by bronchiolitis.
3.Characterization of a novel high-dose ovalbumin-induced murine model of allergic sinonasal inflammation.
Mendiola M1, Tharakan A1, Chen M1, Asempa T1, Lane AP1, Ramanathan M Jr1. Int Forum Allergy Rhinol. 2016 Apr 5. doi: 10.1002/alr.21768. [Epub ahead of print]
BACKGROUND: Few efficacious topical therapies exist for chronic rhinosinusitis (CRS). The lack of a reproducible mouse model of CRS limits the pilot testing of potential novel anti-inflammatory therapies. Although the ovalbumin-induced mouse model of sinonasal inflammation is commonly used, it is difficult to reproduce and can generate variable histologic results. In this study, we explore a variation of this model in different strains of mice and explore various inflammatory cytokines as reproducible molecular markers of inflammation.
4.Effects of Surfactant Lavage Combined With Intratracheal Budesonide Instillation on Meconium-Injured Piglet Lungs.
Lin CH1, Jeng MJ, Kuo BI, Kou YR. Pediatr Crit Care Med. 2016 Apr 27. [Epub ahead of print]
OBJECTIVES: To evaluate the combined effects of surfactant lavage and intratracheally instillation of budesonide on meconium-injured piglet lungs.
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CAS 51333-22-3 Budesonide

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