Buclizine hydrochloride - CAS 129-74-8
Catalog number: B0084-056872
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Histamine Receptor
Buclizine hydrochloride is an antihistamine and anticholinergic of the piperazine derivative family.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-056872 1 g $199 In stock
Bulk Inquiry
> 98%
Related CAS:
129-74-8 (free base)
White to Off-white Solid
Buclizine dihydrochloride; 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride
Melting Point:
Canonical SMILES:
1.Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: relation to lipophilicity and membrane effects.
Fischer MJ1, Paulussen JJ, Horbach DA, Roelofsen EP, van Miltenburg JC, de Mol NJ, Janssen LH. Inflamm Res. 1995 Feb;44(2):92-7.
In a model for mucosal mast cells (RBL-2H3 cells) a set H1-antagonist derived anti-allergic drugs containing a diphenylmethyl piperazinyl moiety was examined for their ability to inhibit release of the mediator beta-hexosaminidase. Cells were activated with antigen or the calcium ionophore A23187, whether or not in combination with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Oxatomide, hydroxyzine and cetirizine inhibit the antigen induced beta-hexosaminidase release. The release triggered by A23187, whether or not in combination with TPA is hardly influenced by the compounds. A biphasic dependence of the inhibition of exocytosis in RBL cells on lipophilicity is observed with the optimum at log P is 5-6. The extremely lipophilic compounds meclozine and buclizine are not active in this model. pH dependence of the effect of the drugs shows that especially the uncharged species are active in inhibiting exocytosis. The investigated compounds show an effect on phase transitions in L-alpha-phosphatidylcholine dipalmitoyl liposomes as assayed with differential scanning calorimetry (DSC).
2.Quantitation of buclizine hydrochloride in pharmaceutical formulations and human serum by RP-HPLC.
Arayne MS1, Sultana N, Siddiqui FA. Pak J Pharm Sci. 2006 Oct;19(4):326-9.
An isocratic reversed phase high-performance liquid chromatographic (HPLC) method with ultraviolet detection at 230 nm has been developed for the determination of buclizine hydrochloride in human serum and dosage formulation. Methylparaben was successfully used as an internal standard. Good chromatographic separation between buclizine and internal standard peaks was achieved by using a stainless steel analytical column Nucleosil, C18 (10 microm, 25 cm x 0.46 cm). The system was operated at room temperature using a mobile phase consisting of acetonitrile-water (1:1) (pH 2.6) with phosphoric acid 85% at a flow rate of 2 ml/min. The calibration curve for buclizine hydrochloride in human serum was linear over the tested concentration range of 10, 3, 1.5, 0.5, 0.15, 0.05, and 0.025 microg/ml with a correlation coefficient of 0.9999. The intra- and inter-run precision and accuracy results were 98.07 to 100.34. The proposed method was validated for selectivity, linearity, accuracy, and precision.
Mostafa GA, Al-Badr AA. Profiles Drug Subst Excip Relat Methodol. 2011;36:1-33. doi: 10.1016/B978-0-12-387667-6.00001-4. Epub 2011 Jun 23.
A comprehensive profile on buclizine hydrochloride, the piperazine derivative which is a sedating antihistamine with antimuscarinic and moderate sedative action and used mainly for its antiemetic effect in the prevention of motion sickness and migraine, is prepared. This profile contains the following sections: description, uses and applications, methods of preparation, physical characteristics, methods of analysis and stability. The physical characteristics section includes solubility, melting range, X-ray powder diffraction pattern, ultraviolet/visible spectroscopy, infrared spectroscopy, proton and carbon-13 nuclear magnetic resonance spectrometry, and mass spectrometry. Methods of analysis section includes compendial BP methods, spectrophotometry, potentiometry, and chromatography (TLC, GC, HPLC).
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Histamine Receptor Products

CAS 903576-44-3 BF 2649

BF 2649
(CAS: 903576-44-3)

Pitolisant hydrochloride is an antagonist of the histamine H3 receptor, which is used for the treatment of narcolepsy with or without cataplexy in adult patient...

CAS 5638-76-6 Betahistine

(CAS: 5638-76-6)

Betahistine is a H1 receptor agonist, which serves as a vasodilator. It is used in Meniere disease and in vascular headaches but may exacerbate bronchial asthma...


(CAS: 1229-35-2)

This active molecular is a first-generation antihistamine and belongs to phenothiazine class. Methdilazine Hydrochloride is a Histamine H1 receptor antagonist w...

CAS 154-69-8 Tripelennamine hydrochloride

Tripelennamine hydrochloride
(CAS: 154-69-8)

Tripelennamine hydrochloride, the hydrochloride salt form of tripelennamine, is a blood-brain barrier penetrant and orally active H1-receptor antagonist. Tripel...

(CAS: 1167574-41-5)

This active molecular is a potent histamine H3 inverse antagonist. Current antipsychotic treatments have little impact on the cognitive deficits associated with...

CAS 153439-40-8 Fexofenadine HCl

Fexofenadine HCl
(CAS: 153439-40-8)

Fexofenadine inhibits histamine H1 receptor with IC50 of 246 nM.

CAS 398473-34-2 JNJ 5207852 dihydrochloride

JNJ 5207852 dihydrochloride
(CAS: 398473-34-2)

The hydrochloride salt form of JNJ 5207852, which has been found to be a histamine H3 receptor antagonist and could probably be used against obesity.

CAS 99291-25-5 Levodropropizine

(CAS: 99291-25-5)

Levodropropizine possess anti-allergic and inhibits histamine receptor, reduces cough by interfering with stimulus activation of peripheral endings of sensory n...

CAS 51481-61-9 Cimetidine

(CAS: 51481-61-9)

Cimetidine, a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.

Famotine hydrochloride
(CAS: 10500-82-0)

Famotine hydrochloride is a histamine H2 receptor antagonist. lt has no effect on the cytochrome P450 enzyme system, and does not appear to interact with other ...

CAS 550-70-9 trans-Triprolidine hydrochloride

trans-Triprolidine hydrochloride
(CAS: 550-70-9)

Trans-Triprolidine hydrochloride is a potent histamine H1 receptor antagonist with anticholinergic properties. Triprolidine is used for the treatment and preven...

FR-A 19
(CAS: 141099-46-9)

FR-A 19 is a Histamine H2 receptor agonist with potent anti-allergic properties. It can inhibit IgE-mediated human basophil histamine release in a nanomolar ran...

CAS 868698-49-1 (R)-(-)-alpha-Methylhistamine dihydrobromide

(R)-(-)-alpha-Methylhistamine dihydrobro
(CAS: 868698-49-1)

(R)-(-)-alpha-Methylhistamine dihydrobromide is a potent and high affinity histamine H3 agonist (KD = 50.3 nM) displaying > 200-fold selectivity over H4 recepto...

CAS 58-33-3 Promethazine hydrochloride

Promethazine hydrochloride
(CAS: 58-33-3)

Promethazine hydrochloride is first-generation antihistamine of the phenothiazine family used as an antiallergic, in pruritus, for motion sickness and sedation,...

CAS 5636-83-9 Dimethindene

(CAS: 5636-83-9)

Dimethindene is a selective histamine H1 antagonist. It binds to the histamine H1 receptor. It is an antiallergic drug and is used in hypersensitivity reactions...

CAS 1028327-66-3 VUF10460

(CAS: 1028327-66-3)

VUF10460 is a specific non-imidazole histamine H4 receptor agonist (pKi= 7.46, 8.22 for rat H4 receptor and human H4 receptor respectively) with 50-fold selecti...

CAS 83881-51-0 Cetirizine

(CAS: 83881-51-0)

Cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine. It is a racemic selective H1 receptor inverse agonist. It is used in cutane...

Bavisant dihydrochloride hydrate
(CAS: 1103522-80-0)

The dihydrochloride hydrate salt form of Bavisant which is an orally bioavaliable and selective H3 receptor antagonist that could probably useful in the treatme...

CAS 1082954-71-9 A 987306

A 987306
(CAS: 1082954-71-9)

A 987306 is a potent histamine H4 receptor antagonist (pKi = 8.24 and 8.47 in human and rat H4 receptors, respectively) with 162-, 620-, and > 1600-fold selecti...

CAS 77-38-3 Chlorphenoxamine

(CAS: 77-38-3)

Chlorphenoxamine is an analog of diphenhydramine. It has antimuscarinic and antihistaminic properties. It has been used as an antipruritic and antiparkinsonian ...

Chemical Structure

CAS 129-74-8 Buclizine hydrochloride

Quick Inquiry

Verification code

Featured Items