Broxaldine - CAS 3684-46-6
Category: APIs
Molecular Formula:
C17H11Br2NO2
Molecular Weight:
421.08
COA:
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Description:
Broxaldine is an antiprotozoal drug.
Purity:
99%
Synonyms:
5,7-Dibromo-8-benzoyloxyquinaldine; 5,7-Dibrom-2-methyl-8-chinolyl benzoat
MSDS:
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InChIKey:
IJTPLVAAROHGGB-UHFFFAOYSA-N
InChI:
InChI=1S/C17H11Br2NO2/c1-10-7-8-12-13(18)9-14(19)16(15(12)20-10)22-17(21)11-5-3-2-4-6-11/h2-9H,1H3
Canonical SMILES:
CC1=NC2=C(C=C1)C(=CC(=C2OC(=O)C3=CC=CC=C3)Br)Br
1.[Toxicity of hydroxyquinoline derivatives].
Pashov D, Simeonov SP, Drumev D, Peĭnikova Ts, Dzhurov A. Vet Med Nauki. 1980;17(3):118-23.
We studied a 90 day toxicity in dogs of the compound broxyquinoline + broxaldine--5:1 (enteroquin), applied orally and daily in doses of 0.1 and 0.2/kg t/24 h. We established the toxic manifestations during the period after the 15th day of the treatment: leukopenia, neutropenia and lymphocytosis (by 0.2 kg t/24 h). After the second and fifth day we observed a decrease of appetite, depression of the CNS, paralyses, arrhythmia, progressing loss in weight, proteinorrhea (more pronounced with those receiving 0.2/kg t (24 h); lethal consequence with some part of the animals 25% (ba 0.1/kg t) and 50% (by 0.2 kg t). We found out pathohistologically necrobiotic changes in the medulla oblongata and the kidneys, toxic distrophy of the liver, blood-vessel injuries. The toxic changes observed can be interpreted in connection with the presence of a species specific reaction.
2.Letter: Effect of broxyquinoline and broxaldine in leprosy.
Sharma CS. Lancet. 1975 Feb 15;1(7903):405.
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CAS 3684-46-6 Broxaldine

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