brompheniramine - CAS 86-22-6
Catalog number: 86-22-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H19BrN2
Molecular Weight:
319.25
COA:
Inquire
Targets:
Histamine Receptor
Description:
Brompheniramine an antihistamine drug.It belongs to the propylamine class. It can be used for the treatment of the symptoms of the common cold and allergic rhinitis. It is a first-generation antihistamine. Brompheniramine also has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin and norepinephrine.
Purity:
98%
Appearance:
Liquid
Synonyms:
3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
the symptoms of the common cold and allergic rhinitis
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Density:
1.265 g/cm3
InChIKey:
ZDIGNSYAACHWNL-UHFFFAOYSA-N
InChI:
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
Canonical SMILES:
CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2
1.Contact allergens in oral antihistamines.
McEnery-Stonelake M1, Silvestri DL. Dermatitis. 2014 Mar-Apr;25(2):83-8. doi: 10.1097/DER.0000000000000028.
BACKGROUND: Excipients in various formulations of active drugs occasionally include known contact allergens. Their ingestion may trigger dermatitis or cause it to become widespread or refractory to therapy.
2.Effects of atomoxetine on attention and impulsivity in the five-choice serial reaction time task in rats with lesions of dorsal noradrenergic ascending bundle.
Liu YP1, Huang TS2, Tung CS3, Lin CC2. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2;56:81-90. doi: 10.1016/j.pnpbp.2014.08.007. Epub 2014 Aug 21.
Atomoxetine, a noradrenaline reuptake inhibitor (NRI), which is a non-stimulating medicine that is used for the treatment of patients with attention deficit hyperactivity disorder (ADHD), has been found to be effective in reducing behavioral impulsivity in rodents, but its efficacy in a dorsal noradrenergic ascending bundle (DNAB)-lesioned condition has not been examined. The present study aimed to investigate the effects of DNAB lesions on attention and impulsive control in the five-choice serial reaction time task (5-CSRTT) in rats treated with atomoxetine. The drug-induced changes in noradrenaline efflux in the medial prefrontal cortex were also measured. 5-CSRTT-trained rats were included in one of the following groups: N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4)/Atomoxetine, Sham/Atomoxetine, DSP-4/Saline, or Sham/Saline. Acute atomoxetine (0.3 mg/kg) was administered 14 days after the DSP-4 regime. The behavioral testing included manipulations of the inter-trial interval (ITI), stimulation duration and food satiety.
3.Preparation of a β-Cyclodextrin-Based Open-Tubular Capillary Electrochromatography Column and Application for Enantioseparations of Ten Basic Drugs.
Fang L1, Yu J1, Jiang Z1, Guo X1. PLoS One. 2016 Jan 15;11(1):e0146292. doi: 10.1371/journal.pone.0146292. eCollection 2016.
An open-tubular capillary electrochromatography column was prepared by chemically immobilized β-cyclodextrin modified gold nanoparticles onto new surface with the prederivatization of (3-mercaptopropyl)-trimethoxysilane. The synthesized nanoparticles and the prepared column were characterized by transmission electron microscopy, scanning electron microscopy, infrared spectroscopy and ultraviolet visible spectroscopy. When the column was employed as the chiral stationary phase, no enantioselectivity was observed for ten model basic drugs. So β-cyclodextrin was added to the background electrolyte as chiral additive to expect a possible synergistic effect occurring and resulting in a better separation. Fortunately, significant improvement in enantioselectivity was obtained for ten pairs of drug enantiomers. Then, the effects of β-cyclodextrin concentration and background electrolyte pH on the chiral separation were investigated. With the developed separation mode, all the enantiomers (except for venlafaxine) were baseline separated in resolutions of 4.
4.Combined use of ionic liquid and hydroxypropyl-β-cyclodextrin for the enantioseparation of ten drugs by capillary electrophoresis.
Cui Y1, Ma X, Zhao M, Jiang Z, Xu S, Guo X. Chirality. 2013 Jul;25(7):409-14. doi: 10.1002/chir.22168. Epub 2013 Jun 6.
In the present study, hydroxypropyl-β-cyclodextrin and an ionic liquid (1-ethyl-3-methylimidazolium-l-lactate) were used as additives in capillary electrophoresis for the enantioseparation of 10 analytes, including ofloxacin, propranolol hydrochloride, dioxopromethazine hydrochloride, isoprenaline hydrochloride, chlorpheniramine maleate, liarozole, tropicamide, amlodipine benzenesulfonate, brompheniramine maleate, and homatropine methylbromide. The effects of ionic liquid concentrations, salt effect, cations, and anions of ionic liquids on enantioseparation were investigated and the results proved that there was a synergistic effect between hydroxypropyl-β-cyclodextrin and the ionic liquid, and the cationic part of the ionic liquid played an important role in the increased resolution. With the developed dual system, all the enantiomers of 10 analytes were well separated in resolutions of 5.35, 1.76, 1.85, 2.48, 2.88, 1.43, 5.45, 4.35, 2.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Histamine Receptor Products


CAS 929622-08-2 Bavisant

Bavisant
(CAS: 929622-08-2)

Bavisant is a highly selective, orally active antagonist of the human H3 receptor. It is a novel mechanism of action, involving wakefulness and cognition. It ha...

CAS 639089-06-8 VUF 5681 dihydrobromide

VUF 5681 dihydrobromide
(CAS: 639089-06-8)

VUF 5681 dihydrobromide is a potent histamine H3 receptor silent antagonist (pKi = 8.35).

CAS 80012-43-7 Epinastine

Epinastine
(CAS: 80012-43-7)

Epinastine is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is highly selective for ...

CAS 87233-62-3 Emedastine Difumarate

Emedastine Difumarate
(CAS: 87233-62-3)

Emedastine is a H1 receptor antagonist. It is a second generation antihistamine. Emedastine can block the action of histamine that causes allergic symptoms. It ...

CAS 90729-43-4 Ebastine

Ebastine
(CAS: 90729-43-4)

Ebastine is a nonsedating type histamine H1-receptor antagonist.

CAS 93793-83-0 Roxatidine Acetate HCl

Roxatidine Acetate HCl
(CAS: 93793-83-0)

Roxatidine Acetate HCl is a specific and competitive histamin H2 receptor antagonist.

CAS 3978-86-7 Azatadine dimaleate

Azatadine dimaleate
(CAS: 3978-86-7)

Azatadine is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.

CAS 76824-35-6 Famotidine

Famotidine
(CAS: 76824-35-6)

Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroe...

CAS 14976-57-9 Clemastine Fumarate

Clemastine Fumarate
(CAS: 14976-57-9)

Clemastine Fumarate (Clemastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.

CAS 59-32-5 Halopyramine

Halopyramine
(CAS: 59-32-5)

Halopyramine is known as a competitive reversible H1-receptor antagonist. It exerts its pharmacological action by competing with histamine for the H1 subtype hi...

CAS 544707-19-9 JNJ10181457 dihydrochloride

JNJ10181457 dihydrochloride
(CAS: 544707-19-9)

JNJ10181457 dihydrochloride is a selective non-imidazole brain penetrant histamine H3 receptor antagonist with pKi values of 8.15 and 8.93 for rat and human H3 ...

CAS 84545-30-2 ICI 162,846

ICI 162,846
(CAS: 84545-30-2)

ICI 162,846 is a potent histamine H2 receptor antagonist.

CAS 562-10-7 Doxylamine Succinate

Doxylamine Succinate
(CAS: 562-10-7)

Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects.

CAS 68-88-2 Hydroxyzine

Hydroxyzine
(CAS: 68-88-2)

Hydroxyzine is a histamine H1-receptor antagonist.

CAS 13461-01-3 aceprometazine

aceprometazine
(CAS: 13461-01-3)

Aceprometazine is a Histamine H1 receptor antagonist as an approved drug. It can be used in combination with meprobamate for the treatment of sleep disorders su...

CAS 699020-93-4 Immethridine dihydrobromide

Immethridine dihydrobromide
(CAS: 699020-93-4)

Immethridine dihydrobromide is the dihydrobromide salt of immethridine, which is a highly selective, potent and novel histamine H3 receptor agonist with pEC50 v...

CAS 142457-00-9 Amthamine dihydrobromide

Amthamine dihydrobromide
(CAS: 142457-00-9)

Amthamine dihydrobromide is the dihydrobromide salt of amthamine, which is a highly selective histamine H2 receptor agonist. It is a weak antagonist at H3 and h...

CAS 58-73-1 Diphenhydramine

Diphenhydramine
(CAS: 58-73-1)

Diphenhydramine is a histamine H1 antagonist. t competitively inhibits the histamine-1 (H1) receptor, thereby alleviating the symptoms caused by endogenous hist...

CAS 1027330-97-7 A 943931

A 943931
(CAS: 1027330-97-7)

A 943931 is a potent and selective histamine H4 receptor antagonist.

GS-283
(CAS: 149440-36-8)

GS-283, an isoquinolin derivative, has been found to be histamine receptor and muscarinic receptor blocker.

Chemical Structure

CAS 86-22-6 brompheniramine

Quick Inquiry

Verification code

Featured Items