brompheniramine - CAS 86-22-6
Catalog number:
86-22-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H19BrN2
Molecular Weight:
319.25
COA:
Inquire
Targets:
Histamine Receptor
Description:
Brompheniramine an antihistamine drug.It belongs to the propylamine class. It can be used for the treatment of the symptoms of the common cold and allergic rhinitis. It is a first-generation antihistamine. Brompheniramine also has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin and norepinephrine.
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Purity:
98%
Appearance:
Liquid
Synonyms:
3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
the symptoms of the common cold and allergic rhinitis
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Density:
1.265 g/cm3
InChIKey:
ZDIGNSYAACHWNL-UHFFFAOYSA-N
InChI:
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
Canonical SMILES:
CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2
1.Contact allergens in oral antihistamines.
McEnery-Stonelake M1, Silvestri DL. Dermatitis. 2014 Mar-Apr;25(2):83-8. doi: 10.1097/DER.0000000000000028.
BACKGROUND: Excipients in various formulations of active drugs occasionally include known contact allergens. Their ingestion may trigger dermatitis or cause it to become widespread or refractory to therapy.
2.Effects of atomoxetine on attention and impulsivity in the five-choice serial reaction time task in rats with lesions of dorsal noradrenergic ascending bundle.
Liu YP1, Huang TS2, Tung CS3, Lin CC2. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2;56:81-90. doi: 10.1016/j.pnpbp.2014.08.007. Epub 2014 Aug 21.
Atomoxetine, a noradrenaline reuptake inhibitor (NRI), which is a non-stimulating medicine that is used for the treatment of patients with attention deficit hyperactivity disorder (ADHD), has been found to be effective in reducing behavioral impulsivity in rodents, but its efficacy in a dorsal noradrenergic ascending bundle (DNAB)-lesioned condition has not been examined. The present study aimed to investigate the effects of DNAB lesions on attention and impulsive control in the five-choice serial reaction time task (5-CSRTT) in rats treated with atomoxetine. The drug-induced changes in noradrenaline efflux in the medial prefrontal cortex were also measured. 5-CSRTT-trained rats were included in one of the following groups: N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4)/Atomoxetine, Sham/Atomoxetine, DSP-4/Saline, or Sham/Saline. Acute atomoxetine (0.3 mg/kg) was administered 14 days after the DSP-4 regime. The behavioral testing included manipulations of the inter-trial interval (ITI), stimulation duration and food satiety.
3.Preparation of a β-Cyclodextrin-Based Open-Tubular Capillary Electrochromatography Column and Application for Enantioseparations of Ten Basic Drugs.
Fang L1, Yu J1, Jiang Z1, Guo X1. PLoS One. 2016 Jan 15;11(1):e0146292. doi: 10.1371/journal.pone.0146292. eCollection 2016.
An open-tubular capillary electrochromatography column was prepared by chemically immobilized β-cyclodextrin modified gold nanoparticles onto new surface with the prederivatization of (3-mercaptopropyl)-trimethoxysilane. The synthesized nanoparticles and the prepared column were characterized by transmission electron microscopy, scanning electron microscopy, infrared spectroscopy and ultraviolet visible spectroscopy. When the column was employed as the chiral stationary phase, no enantioselectivity was observed for ten model basic drugs. So β-cyclodextrin was added to the background electrolyte as chiral additive to expect a possible synergistic effect occurring and resulting in a better separation. Fortunately, significant improvement in enantioselectivity was obtained for ten pairs of drug enantiomers. Then, the effects of β-cyclodextrin concentration and background electrolyte pH on the chiral separation were investigated. With the developed separation mode, all the enantiomers (except for venlafaxine) were baseline separated in resolutions of 4.
4.Combined use of ionic liquid and hydroxypropyl-β-cyclodextrin for the enantioseparation of ten drugs by capillary electrophoresis.
Cui Y1, Ma X, Zhao M, Jiang Z, Xu S, Guo X. Chirality. 2013 Jul;25(7):409-14. doi: 10.1002/chir.22168. Epub 2013 Jun 6.
In the present study, hydroxypropyl-β-cyclodextrin and an ionic liquid (1-ethyl-3-methylimidazolium-l-lactate) were used as additives in capillary electrophoresis for the enantioseparation of 10 analytes, including ofloxacin, propranolol hydrochloride, dioxopromethazine hydrochloride, isoprenaline hydrochloride, chlorpheniramine maleate, liarozole, tropicamide, amlodipine benzenesulfonate, brompheniramine maleate, and homatropine methylbromide. The effects of ionic liquid concentrations, salt effect, cations, and anions of ionic liquids on enantioseparation were investigated and the results proved that there was a synergistic effect between hydroxypropyl-β-cyclodextrin and the ionic liquid, and the cationic part of the ionic liquid played an important role in the increased resolution. With the developed dual system, all the enantiomers of 10 analytes were well separated in resolutions of 5.35, 1.76, 1.85, 2.48, 2.88, 1.43, 5.45, 4.35, 2.
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Chemical Structure

CAS 86-22-6 brompheniramine

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