Bromethalin - CAS 63333-35-7
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Not Intended for Therapeutic Use. For research use only.
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Bromethalin is a new rodenticide for the control of commensal rodents.
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1.Method for the detection of desmethylbromethalin in animal tissue samples for the determination of bromethalin exposure.
Filigenzi MS1, Bautista AC1, Aston LS1, Poppenga RH1. J Agric Food Chem. 2015 Jun 3;63(21):5146-51. doi: 10.1021/jf5052706. Epub 2015 Mar 3.
Bromethalin, a potent neurotoxin, is widely available for use as a rodenticide. As access to other rodenticides is reduced due to regulatory pressure, the use of bromethalin is likely to increase with a concomitant increase in poisonings in nontarget animals. Analytical methods for the detection of bromethalin residues in animals suspected to have been exposed to this rodenticide are needed to support post-mortem diagnosis of toxicosis. This paper describes a novel method for the analysis of desmethylbromethalin (DMB), bromethalin's toxic metabolite, in tissue samples such as liver, brain, and adipose. Samples were extracted with 5% ethanol in ethyl acetate, and an aliquot of the extract was evaporated dry, reconstituted, and analyzed by reverse phase ultrahigh-performance liquid chromatography-mass spectrometry. The mass spectrometer utilized electrospray ionization in negative ion mode with multiple reaction monitoring. This method was qualitatively validated at a level of 1.
2.Initial biological qualification of SBDP-145 as a biomarker of compound-induced neurodegeneration in the rat.
Pritt ML1, Hall DG2, Jordan WH3, Ballard DW2, Wang KK4, Müller UR5, Watson DE2. Toxicol Sci. 2014 Oct;141(2):398-408. doi: 10.1093/toxsci/kfu136. Epub 2014 Jul 11.
Detection of compound-related neurodegeneration is currently limited to brain histopathology in veterinary species and functional measurements such as electroencephalography and observation of clinical signs in patients. The objective of these studies was to investigate whether concentrations of spectrin breakdown product 145 (SBDP-145) in cerebrospinal fluid (CSF) correlate with the severity of neurodegeneration in rats administered neurotoxic agents, as part of a longer term objective of developing in vivo biomarkers of neurotoxicity for use in non-clinical and clinical safety studies. Non-erythroid alpha-II spectrin is a cytoskeletal protein cleaved by the protease calpain when this enzyme is activated by dysregulation of calcium in injured cells. Calcium dysregulation is also associated with some toxicological responses in animals, and may be sufficient to activate neuronal calpain and produce SBDPs that can be released into CSF. Neurotoxicants (kainic acid, 2-chloropropionic acid, bromethalin, and pentylenetetrazole) known to affect different portions of the brain were administered to rats in dose-response and time-course studies in which neurodegeneration was measured by histopathology and SBDP-145 concentrations in CSF were measured by ELISA.
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CAS 63333-35-7 Bromethalin

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