BRL-37344 sodium - CAS 127299-93-8
Catalog number:
127299-93-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H21ClNNaO4
Molecular Weight:
385.82
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
BRL37344 is a selective β3-adrenergic receptor agonist originated by GlaxoSmithKline. Ki value is 287nM for β3 receptor, 1750nM for β1 receptor and 1120nM for β2 receptor. BRL37344 can decrease nerve-evoked contractions in human detrusor smooth muscle isolated strips, it can also stimulate fuel oxidation by soleus muscle in vitro. BRL37344 increases glucose transport into L6 myocytes through a mechanism different from that of insulin. But preclinical for Diabetes mellitus was discontinued.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98 %
Appearance:
White solid
Synonyms:
sodium;2-[4-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetate
Solubility:
Soluble to 100 mM in water
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Diabetes mellitus
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
SNJIJYKMYQRHRC-WJKBNZMCSA-M
InChI:
InChI=1S/C19H22ClNO4.Na/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24;/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24);/q;+1/p-1/t13-,18+;/m1./s1
Canonical SMILES:
CC(CC1=CC=C(C=C1)OCC(=O)[O-])NCC(C2=CC(=CC=C2)Cl)O.[Na+]
Current Developer:
Originator: GlaxoSmithKline
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Adrenergic Receptor Products


CAS 964-52-3 Moxisylyte hydrochloride

Moxisylyte hydrochloride
(CAS: 964-52-3)

Moxisylyte hydrochloride is alpha 1-adrenoceptor antagonist. It can vasodilates cerebral vessels without reducing blood pressure. It is used as peripheral vasod...

CAS 33402-03-8 Metaraminol tartrate

Metaraminol tartrate
(CAS: 33402-03-8)

Metaraminol is a stereoisomer of meta-hydroxynorephedrine, acts as An adrenergic agonist that increases both systolic and diastolic blood pressure.

CP 59430
(CAS: 86329-06-8)

CP 59430 is an azide analog of prazosin. It is a selective alpha 1-adrenergic receptor antagonist.

CAS 81732-46-9 Bambuterol HCl

Bambuterol HCl
(CAS: 81732-46-9)

Bambuterol is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma.

CAS 1218-35-5 Xylometazoline HCl

Xylometazoline HCl
(CAS: 1218-35-5)

Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.

CAS 63-92-3 Phenoxybenzamine HCl

Phenoxybenzamine HCl
(CAS: 63-92-3)

Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.

CAS 58020-43-2 Hoku-81

Hoku-81
(CAS: 58020-43-2)

Hoku 81 is a bronchodilator, and one of the metabolites of tulobuterol.

CAS 79689-25-1 DG5128

DG5128
(CAS: 79689-25-1)

DG5128, a new oral hypoglycemic agent, is an orally available preferential antagonist of α2-adrenoceptor with 7.4 times higher affinity toward α2-adrenoceptor t...

CAS 13609-67-1 Hydrocortisone-17-butyrate

Hydrocortisone-17-butyrate
(CAS: 13609-67-1)

Hydrocortisone-17-butyrate, a glucocorticoid compound, could be used as antiinflammatory and immunosuppresive agent.

CHIR 2279
(CAS: 158198-45-9)

CHIR 2279, an isoquinolin derivative, was once studied against hypertension as an α1 adrenergic receptor antagonist.

CAS 104054-27-5 Atipamezole

Atipamezole
(CAS: 104054-27-5)

Atipamezole, a 4-substituted imidazole derivative, is an alpha2-adrenoceptor blocker which could be used for animals to recover from the anesthesia by lowering ...

CAS 161905-64-2 α1 adrenoceptor-MO-1

α1 adrenoceptor-MO-1
(CAS: 161905-64-2)

An S enantiomer which has affinity at alpha 1 adrenergic receptor

CAS 586-06-1 Orciprenaline

Orciprenaline
(CAS: 586-06-1)

Orciprenaline is a moderately selective beta-adrenergic agonist used in the treatment of asthma and bronchospasms. It stimulates receptors of the smooth muscle ...

CAS 41372-08-1 L-α-Methyl DOPA Hydrate

L-α-Methyl DOPA Hydrate
(CAS: 41372-08-1)

L-α-Methyl DOPA Hydrate is an alpha-adrenergic agonist used as a sympatholytic or antihypertensive.

CAS 65-28-1 Phentolamine Mesylate

Phentolamine Mesylate
(CAS: 65-28-1)

Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist with IC50 of 0.1 μM.

CAS 22195-34-2 Guanadrel Hemisulfate

Guanadrel Hemisulfate
(CAS: 22195-34-2)

Guanadrel, as an antihypertensive agent, is an orally active postganglionic sympathetic inhibitor.

CAS 18559-94-9 Salbutamol

Salbutamol
(CAS: 18559-94-9)

Salbutamol is a short-acting agonist that specifically targets β2-adrenergic receptor to alleviate bronchospasm in conditions such as asthma and chronic obstruc...

CAS 329-65-7 DL-Adrenaline

DL-Adrenaline
(CAS: 329-65-7)

DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands.

CAS 62929-91-3 Procaterol hydrochloride

Procaterol hydrochloride
(CAS: 62929-91-3)

Procaterol hydrochloride is a long-acting, very potent and specific beta-2-adrenergic receptor agonist. It acts as a vasodialator for long term treatment of ast...

Aptazapine maleate
(CAS: 71576-41-5)

Aptazapine is a tetracyclic antidepressant. It was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. Aptazapine is...

Chemical Structure

CAS 127299-93-8 BRL-37344 sodium

Quick Inquiry

Verification code

Featured Items