BRL-37344 sodium - CAS 127299-93-8
Catalog number: 127299-93-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H21ClNNaO4
Molecular Weight:
385.82
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
BRL37344 is a selective β3-adrenergic receptor agonist originated by GlaxoSmithKline. Ki value is 287nM for β3 receptor, 1750nM for β1 receptor and 1120nM for β2 receptor. BRL37344 can decrease nerve-evoked contractions in human detrusor smooth muscle isolated strips, it can also stimulate fuel oxidation by soleus muscle in vitro. BRL37344 increases glucose transport into L6 myocytes through a mechanism different from that of insulin. But preclinical for Diabetes mellitus was discontinued.
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Purity:
98 %
Appearance:
White solid
Synonyms:
sodium;2-[4-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetate
Solubility:
Soluble to 100 mM in water
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Diabetes mellitus
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
SNJIJYKMYQRHRC-WJKBNZMCSA-M
InChI:
InChI=1S/C19H22ClNO4.Na/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24;/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24);/q;+1/p-1/t13-,18+;/m1./s1
Canonical SMILES:
CC(CC1=CC=C(C=C1)OCC(=O)[O-])NCC(C2=CC(=CC=C2)Cl)O.[Na+]
Current Developer:
Originator: GlaxoSmithKline
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CAS 127299-93-8 BRL-37344 sodium

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