BRCA1-IN-1 - CAS 1622262-74-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H33F2N4O6P
Molecular Weight:
578.54
COA:
Inquire
Targets:
PARP
Description:
A novel small-molecule-like BRCA1 inhibitor (IC50= 0.53 μM) (Ki= 0.71 μM)
Synonyms:
[(3S)-1,1-difluoro-3-[3-(1H-indol-3-yl)propanoylamino]-4-oxo-4-[[2-oxo-2-(4-phenylbutylamino)ethyl]amino]butyl]phosphonic acid
Solubility:
DMSO
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Density:
1.360±0.06 g/cm3
InChIKey:
ONHSSHPYNSJFHU-QHCPKHFHSA-N
InChI:
1S/C27H33F2N4O6P/c28-27(29,40(37,38)39)16-23(33-24(34)14-13-20-17-31-22-12-5-4-11-21(20)22)26(36)32-18-25(35)30-15-7-6-10-19-8-2-1-3-9-19/h1-5,8-9,11-12,17,23,31H,6-7,10,13-16,18H2,(H,30,35)(H,32,36)(H,33,34)(H2,37,38,39)/t23-/m0/s1
Canonical SMILES:
C1=CC=C(C=C1)CCCCNC(=O)CNC(=O)C(CC(F)(F)P(=O)(O)O)NC(=O)CCC2=CNC3=CC=CC=C32
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related PARP Products


CAS 1345098-78-3 XMD16-5

XMD16-5
(CAS: 1345098-78-3)

XMD16-5is a novel non-receptor tyrosine kinase TNK2 inhibitor (IC50= 16 nM and 77 nM for D163E and R806Q mutant TNK2, respectively)

KU 0058948 hydrochloride

KU 0058948 hydrochloride is a potent poly ADP-ribose polymeras (PARP) inhibitor (IC50: 3.4 nM for PARP1). In vitro, KU-0058948 activates transfected extracellul...

CAS 252889-88-6 RWJ 56110

RWJ 56110
(CAS: 252889-88-6)

RWJ 56110 is a selective Thrombin R protease-activated receptor (PAR)-1 antagonist which exhibits no activity at PAR2, PAR3, or PAR4 subtypes. It blocks thrombi...

CAS 3544-24-9 3-Aminobenzamide

3-Aminobenzamide
(CAS: 3544-24-9)

3-Aminobenzamide is a competitive PARP inhibitor with Ki of 1.8 μM.

NMS-P118
(CAS: 1262417-51-5)

NMS-P118 is a highly selective Poly(ADP-ribose) Polymerase 1 (PARP-1) inhibitor with excellent ADME, pharmacokinetic profiles and high efficacy in vivo originat...

CAS 1104546-89-5 BYK 204165

BYK 204165
(CAS: 1104546-89-5)

BYK 204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 = 5.38 and 7.35 for PARP-2 and PARP-1, respectively). BYK 204165 is 1...

CAS 459868-92-9 Rucaparib Phosphate

Rucaparib Phosphate
(CAS: 459868-92-9)

Rucaparib Phosphate is a selective PARP inhibitor that suppresses the PARP1-mediated DNA repair via binding to PARP1 (Ki = <5 nM). It can be used to sensitize c...

CAS 459868-92-9 Rucaparib

Rucaparib
(CAS: 459868-92-9)

Rucaparib, also known as (AG-14699 or PF-01367338, is a tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiose...

Protease-Activated Receptor-2, amide

Protease-Activated Receptor-2, amide, also known as SLIGKV-NH2, is a highly potent protease-activated receptor-2 (PAR2) activating peptide and can also be utliz...

CAS 1065755-99-8 Parstatin (human)

Parstatin (human)
(CAS: 1065755-99-8)

Parstatin is a 41-amino acid peptide, formed by proteolytic cleavage on activation of the protease activated receptor-1, with antiangiogenic properties. Parstat...

CAS 163120-31-8 BYK 49187

BYK 49187
(CAS: 163120-31-8)

BYK 49187 is a non-selective PARP inhibitor (pIC50 = 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2, respectively).

CAS 664993-53-7 JW55

JW55
(CAS: 664993-53-7)

JW 55 is a potent and selective β-catenin signaling pathway inhibitor, which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2...

CAS 5154-02-9 1,5-Isoquinolinediol

1,5-Isoquinolinediol
(CAS: 5154-02-9)

1,5-Isoquinolinediol is a PARP1 inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent leading to an increase up to 8-fold in the absolute frequency of...

CAS 160003-66-7 Iniparib

Iniparib
(CAS: 160003-66-7)

BSI-201 is a small-molecule prodrug inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) with potential chemosensitizing, radiosensitizing and...

CAS 197794-83-5 TFLLR-NH2

TFLLR-NH2
(CAS: 197794-83-5)

TFLLR-NH2, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM.

CAS 1419949-20-4 TNKS656

TNKS656
(CAS: 1419949-20-4)

NVP-TNKS656, also known as TNKS656, is a potent and orally active Tankyrase Inhibitor. With an enthalpy-driven thermodynamic signature of binding, highly favor...

CAS 1140964-99-3 E7449

E7449
(CAS: 1140964-99-3)

E7449 is an orally bioavailable, potent, small molecule inhibitor of PARP1 and PARP2, which enhances the efficacy of radiotherapy and chemotherapy and has poten...

CAS 283173-50-2 Rucaparib

Rucaparib
(CAS: 283173-50-2)

Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a ...

AZ6102
(CAS: 1645286-75-4)

AZ6102 is a moderate oral bioavailable dual inhibitor of TNKS1/2 with excellent selectivity against other PARP family enzymes including PARP-1, PARP-2 and PARP-...

CAS 1207456-01-6 Talazoparib

Talazoparib
(CAS: 1207456-01-6)

Talazoparib, also known as BMN-673, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic a...

Chemical Structure

CAS 1622262-74-1 BRCA1-IN-1

Quick Inquiry

Verification code

Featured Items