|Description||Bradanicline hydrochloride is Alpha-7 Nicotinic Receptor Agonist. It showed cognitive enhancing effects in animal studies, and was being developed as a potential treatment for schizophrenia and attention deficit disorder. It was discontinued for Alzheimer's disease and cognitive impairment in schizophrenia in late 2013. It was also discontinued for ADHD, and no longer seems to be being developed.|
|Solubility||10 mM in DMSO|
|Application||Bradanicline hydrochloride was being developed as a potential treatment for schizophrenia and attention deficit disorder.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
Bradanicline hydrochloride is Alpha-7 Nicotinic Receptor Agonist. It showed cognitive enhancing effects in animal studies, and was being developed as a potentia...
Vecuronium bromide (Norcuron) is a muscle relaxant in the category of non-depolarizing blocking agents. Vecuronium bromide is indicated as an adjunct to general...
EVP-6124 is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). It shows selectivity for α7 nAChRs and did not activate or inhibi...
CP-601927 is a CNS-penetrant, high affinity, and selective nicotinic acetylcholine receptor (nAChR) agonist.
PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.
Highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). Found to be inactive against a panel of ...
The hydrochloride salt form of Procyclidine which has been found to be a muscarinic antagonist that could be effective against Parkinson's disease and some rela...
Pentolonium tartrate is the tartrate salt form of pentolinium, which is a ganglionic blocking agent and acts as a nicotinic acetylcholine receptor antagonist. I...
Sofinicline is a novel nicotinic acetylcholine receptor agonist under development of Abbott Laboratories. Till now, no development was reported for Phase-II for...
Tebanicline hydrochloride is the hydrochloride salt of Tebanicline (ABT-594) which is a neuronal nicotinic acetyl-choline receptor agonist and has been describe...
AT 1001 is a partial agonist and antagonist of α3β4 nAChR ligand (Ki value 2.6 nM at α3β4 nAChR). In vivo AT-1001 potently blocks nicotine self-administration i...
Varenicline (trade name Chantix in the USA and Champix in Canada, Europe and other countries, marketed by Pfizer, usually in the form of varenicline tartrate), ...
A-366833 is a an agonist at neural nicotinic acetylcholine receptors selective for the α4β2 subtype.
Encenicline, HCl salt
EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community: it acts as a co-ago...
Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.
Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.
Trimetaphan camsilate can counteract cholinergic transmission at the ganglion type of nicotinic receptors of the autonomic ganglia and this lead to block both t...
Varenicline(CP 526555; Champix; Chantix) is a prescription medication used to treat smoking addiction. As a partial agonist it both reduces cravings for and dec...
PHA 543613 dihydrochloride
PHA 543613 dihydrochloride is a potent and selective α7 nicotinic acetylcholine receptor (nAChR) agonist with rapid brain penetration and high oral bioavailabil...
Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.