Boswellic acid - CAS 471-66-9
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
α-Boswellic acid is the principal constitutents of frankincense (olibanum). It is a specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.
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White solid
α-Boswellic Acid; (3α,4β)-3-Hydroxyolean-12-en-23-oic Acid; 3α-hydroxyolean-12-en-24-oic Acid; 3α-Acetyl-α-boswellic Acid; alpha-Boswellic Acid;
Soluble in DMSO
Store at -20 °C
A specific, nonredox inhibitor
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Canonical SMILES:
1.Development and optimization of boswellic acid-loaded proniosomal gel.
Mehta M1, Dureja H1, Garg M1. Drug Deliv. 2016 Mar 8:1-10. [Epub ahead of print]
CONTEXT: Boswellic acids (BAs) are isolated from oleo gum of Boswellia serrata and are mainly used as potential anti-inflammatory, hypolipidemic, immunomodulatory, and antitumor agents. Pharmacokinetic investigations of BAs uncover its poor bioavailability through digestive system thus creates a need for improved therapeutic responses which can possibly be achieved by developing formulations through novel delivery system.
2.Alpha-boswellic acid protects against ethanol-induced gastric injury in rats: involvement of nuclear factor erythroid-2-related factor 2/heme oxygenase-1 pathway.
Zhang Y1,2, Jia J3, Ding Y1, Ma Y4, Shang P1, Liu T1, Hui G2, Wang L5, Wang M1, Zhu Z1, Li Y1, Wen A1. J Pharm Pharmacol. 2016 Apr;68(4):514-22. doi: 10.1111/jphp.12532. Epub 2016 Mar 14.
OBJECTIVES: The purpose of this study was to assess the gastroprotective properties of alpha-boswellic acid (α-BA), a pentacyclic triterpene compound from extracts of Frankincense.
3.Co-administration of 3-Acetyl-11-Keto-Beta-Boswellic Acid Potentiates the Protective Effect of Celecoxib in Lipopolysaccharide-Induced Cognitive Impairment in Mice: Possible Implication of Anti-inflammatory and Antiglutamatergic Pathways.
Sayed AS1, El Sayed NS2,3. J Mol Neurosci. 2016 May;59(1):58-67. doi: 10.1007/s12031-016-0734-7. Epub 2016 Mar 16.
Neuro-inflammation is known to initiate the underlying pathogenesis of several neurodegenerative disorders which may progress to cognitive, behavioral, and functional impairment. Boswellia serrata is a well-known powerful anti-inflammatory agent used to treat several inflammatory diseases. The aim of the current study is to investigate the effect of the combination therapy of 3-acetyl-11-keto-β-boswellic acid (AKBA), a 5-lipoxygenase (5-LOX) inhibitor and celecoxib, and a selective cyclooxygenase-2 (COX-2) inhibitor as dual enzyme inhibitors compared to monotherapies with celecoxib and AKBA. Cognitive dysfunction is induced by intraperational injection of lipopolysaccharide (LPS) in mice. Radial maze, Y maze, and novel object recognition (NOR) were performed to evaluate the possible behavioral changes. Moreover, estimation of glutamate and tumor necrosis factor-alpha (TNF-α), as well as an immunohistochemical investigation of amyloid beta peptide (Aβ) was performed to evaluate the molecular changes that followed the LPS or drug treatment.
4.Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-β-boswellic acid in combination on isoproterenol-induced myocardial injury in rats.
Chen M1, Wang M1, Yang Q1, Wang M2, Wang Z2, Zhu Y1, Zhang Y1, Wang C1, Jia Y1, Li Y1, Wen A1. Int J Mol Med. 2016 Apr 20. doi: 10.3892/ijmm.2016.2571. [Epub ahead of print]
Oxidative stress plays an important role in the initiation and development of myocardial injury (MI). The peroxisome proliferator-activated receptor gamma coactivator-1α (PGC‑1α)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is considered to be a potential target for cardioprotection in MI. Acetyl-11-keto-β-boswellic acid (AKBA) is the major organic acid component extracted from Boswellia serrata Roxb. ex Colebr. Hydroxysafflor yellow A (HSYA) is the principal active constituent of Carthamus tinctorius L. In the present study, we aimed to investigate the cardioprotective effects of HSYA and AKBA in combination in vivo and in vitro, as well as the underlying mechanisms responsible for these effects. For this purpose, MI was produced in Sprague-Dawley rats by subcutaneous injection with isoproterenol. To model ischemic-like conditions in vitro, H9C2 cells were subjected to oxygen-glucose deprivation (OGD). The levels of creatine kinase-MB (CK‑MB), lactate dehydrogenase (LDH), malondialdehyde (MDA) as well as superoxide dismutase (SOD) activity were examined as well as apoptotic cell death.
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CAS 471-66-9 Boswellic acid

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