Boswellic acid - CAS 471-66-9
Catalog number:
471-66-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C30H48O3
Molecular Weight:
456.7
COA:
Inquire
Targets:
Others
Description:
α-Boswellic acid is the principal constitutents of frankincense (olibanum). It is a specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥98%
Appearance:
White solid
Synonyms:
α-Boswellic Acid; (3α,4β)-3-Hydroxyolean-12-en-23-oic Acid; 3α-hydroxyolean-12-en-24-oic Acid; 3α-Acetyl-α-boswellic Acid; alpha-Boswellic Acid;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A specific, nonredox inhibitor
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
BZXULBWGROURAF-IKNLXHIFSA-N
InChI:
1S/C30H48O3/c1-25(2)14-15-26(3)16-17-28(5)19(20(26)18-25)8-9-21-27(4)12-11-23(31)30(7,24(32)33)22(27)10-13-29(21,28)6/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21+,22+,23+,26+,27+,28+,29+,30+/m0/s1
Canonical SMILES:
CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C(=O)O)O)C)C)C2C1)C)C)C
1.Development and optimization of boswellic acid-loaded proniosomal gel.
Mehta M1, Dureja H1, Garg M1. Drug Deliv. 2016 Mar 8:1-10. [Epub ahead of print]
CONTEXT: Boswellic acids (BAs) are isolated from oleo gum of Boswellia serrata and are mainly used as potential anti-inflammatory, hypolipidemic, immunomodulatory, and antitumor agents. Pharmacokinetic investigations of BAs uncover its poor bioavailability through digestive system thus creates a need for improved therapeutic responses which can possibly be achieved by developing formulations through novel delivery system.
2.Alpha-boswellic acid protects against ethanol-induced gastric injury in rats: involvement of nuclear factor erythroid-2-related factor 2/heme oxygenase-1 pathway.
Zhang Y1,2, Jia J3, Ding Y1, Ma Y4, Shang P1, Liu T1, Hui G2, Wang L5, Wang M1, Zhu Z1, Li Y1, Wen A1. J Pharm Pharmacol. 2016 Apr;68(4):514-22. doi: 10.1111/jphp.12532. Epub 2016 Mar 14.
OBJECTIVES: The purpose of this study was to assess the gastroprotective properties of alpha-boswellic acid (α-BA), a pentacyclic triterpene compound from extracts of Frankincense.
3.Co-administration of 3-Acetyl-11-Keto-Beta-Boswellic Acid Potentiates the Protective Effect of Celecoxib in Lipopolysaccharide-Induced Cognitive Impairment in Mice: Possible Implication of Anti-inflammatory and Antiglutamatergic Pathways.
Sayed AS1, El Sayed NS2,3. J Mol Neurosci. 2016 May;59(1):58-67. doi: 10.1007/s12031-016-0734-7. Epub 2016 Mar 16.
Neuro-inflammation is known to initiate the underlying pathogenesis of several neurodegenerative disorders which may progress to cognitive, behavioral, and functional impairment. Boswellia serrata is a well-known powerful anti-inflammatory agent used to treat several inflammatory diseases. The aim of the current study is to investigate the effect of the combination therapy of 3-acetyl-11-keto-β-boswellic acid (AKBA), a 5-lipoxygenase (5-LOX) inhibitor and celecoxib, and a selective cyclooxygenase-2 (COX-2) inhibitor as dual enzyme inhibitors compared to monotherapies with celecoxib and AKBA. Cognitive dysfunction is induced by intraperational injection of lipopolysaccharide (LPS) in mice. Radial maze, Y maze, and novel object recognition (NOR) were performed to evaluate the possible behavioral changes. Moreover, estimation of glutamate and tumor necrosis factor-alpha (TNF-α), as well as an immunohistochemical investigation of amyloid beta peptide (Aβ) was performed to evaluate the molecular changes that followed the LPS or drug treatment.
4.Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-β-boswellic acid in combination on isoproterenol-induced myocardial injury in rats.
Chen M1, Wang M1, Yang Q1, Wang M2, Wang Z2, Zhu Y1, Zhang Y1, Wang C1, Jia Y1, Li Y1, Wen A1. Int J Mol Med. 2016 Apr 20. doi: 10.3892/ijmm.2016.2571. [Epub ahead of print]
Oxidative stress plays an important role in the initiation and development of myocardial injury (MI). The peroxisome proliferator-activated receptor gamma coactivator-1α (PGC‑1α)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is considered to be a potential target for cardioprotection in MI. Acetyl-11-keto-β-boswellic acid (AKBA) is the major organic acid component extracted from Boswellia serrata Roxb. ex Colebr. Hydroxysafflor yellow A (HSYA) is the principal active constituent of Carthamus tinctorius L. In the present study, we aimed to investigate the cardioprotective effects of HSYA and AKBA in combination in vivo and in vitro, as well as the underlying mechanisms responsible for these effects. For this purpose, MI was produced in Sprague-Dawley rats by subcutaneous injection with isoproterenol. To model ischemic-like conditions in vitro, H9C2 cells were subjected to oxygen-glucose deprivation (OGD). The levels of creatine kinase-MB (CK‑MB), lactate dehydrogenase (LDH), malondialdehyde (MDA) as well as superoxide dismutase (SOD) activity were examined as well as apoptotic cell death.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 894-71-3 Nortriptyline hydrochloride

Nortriptyline hydrochloride
(CAS: 894-71-3)

Nortriptyline hydrochloride is a second-generation tricyclic antidepressant (TCA) marketed as the hydrochloride salt under the trade names Sensoval, Aventyl and...

CAS 7770-78-7 Arctigenin

Arctigenin
(CAS: 7770-78-7)

Arctigenin is the aglycone of arctiin and is a lignan found in certain plants of the Asteraceae. It has shown antiviral and anticancer effects in glass. It show...

CAS 50-33-9 Phenylbutazone

Phenylbutazone
(CAS: 50-33-9)

Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis. In the United States a...

WRR483
(CAS: 1076088-50-0)

WRR483 is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model. It is an analogue of K-11777. It demon...

GSK256471
(CAS: 1133706-08-7)

This active molecular is a selective and potent NK(3) antagonist. It has a high affinity for recombinant human (pK(i) value 8.9) and native guinea pig (pK(i) va...

Namitecan
(CAS: 372105-27-6)

Namiteca is a new water-soluble camptothecin analogue as a hydrophilic camptothecin with a promising preclinical profile.

CAS 129186-29-4 Gidazepam

Gidazepam
(CAS: 129186-29-4)

Gidazepam has a 3-fold higher affinity for MBR than for CBR (IC50= 710 and 2200 nmol/L, respectively).

CAS 68370-47-8 Micheliolide

Micheliolide
(CAS: 68370-47-8)

Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in...

CAS 36338-96-2 Safflower Yellow

Safflower Yellow
(CAS: 36338-96-2)

Extract from Carthamin, widely used for the treatment of acute ischemic stroke by acting directly on BV2 microglia.

CAS 899507-36-9 A 438079 hydrochloride

A 438079 hydrochloride
(CAS: 899507-36-9)

A 438079 hydrochloride is a competitive P2X7 receptor antagonist with pIC50 value of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell li...

CAS 530141-72-1 T-5224

T-5224
(CAS: 530141-72-1)

T-5224 is a selective inhibitor of c-Fos/activator protein-1. T-5224 ameliorates liver injury and improves survival through decreasing production of proinflamma...

CAS 2934-97-6 Tetrahydropalmatine

Tetrahydropalmatine
(CAS: 2934-97-6)

Tetrahydropalmatine depletes neurotransmitters such as dopamine, noradrenaline and serotonin. L-Tetrahydropalmatine is an inhibitor of D3DR. L-Tetrahydropalmati...

CAS 153777-70-9 DOTA derivative

DOTA derivative
(CAS: 153777-70-9)

DOTA derivative is a benxyl derivative of the cyclic tosamide; can be nitrated directly; is more convenient to incorporate the nitro group after deprotection li...

CAS 56-04-2 Methylthiouracil

Methylthiouracil
(CAS: 56-04-2)

Methylthiouracil is an antithyroid preparation.The drug acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland.

CAS 880090-88-0 Neuropathiazol

Neuropathiazol
(CAS: 880090-88-0)

Neuropathiazol is a synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. It selectively induces neuronal...

CAS 101932-71-2 CALYCULIN A

CALYCULIN A
(CAS: 101932-71-2)

Calyculin A is a effective inhibitor of the catalytic subunit of type-2A phosphatase as well as the type-1 phosphatase. IC50: 0.5 to 1 nM and 2 nM,respectively....

CAS 81720-05-0 Rehmannioside A

Rehmannioside A
(CAS: 81720-05-0)

Rehmannioside A is an iridoid glucoside extracted from the roots of Rehmannia glutinosa.

CAS 112-38-9 10-Undecylenic Acid

10-Undecylenic Acid
(CAS: 112-38-9)

10-Undecylenic Acid, a long-chain fatty acid substance, could be used as a monomer in the polymerization and also a raw material in the syntheses of Pheromone (...

CGP 76030
(CAS: 497152-38-2)

CGP76030 is a ual-specific Src and Abl kinase inhibitor, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases.

Vapreotide acetate
(CAS: 849479-74-9)

Vapreotide is a synthetic somatostatin analog as a Somatotropin receptor antagonist. It can be used for the treatment of esophageal variceal bleeding in patient...

Chemical Structure

CAS 471-66-9 Boswellic acid

Quick Inquiry

Verification code

Featured Items