(+)-Borneol - CAS 464-43-7
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Molecular Formula:
Molecular Weight:
Chemical Family:
Borneol; Isoborneol; (1R,2S,4R)-rel-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol
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1.(+)-Borneol attenuates oxaliplatin-induced neuropathic hyperalgesia in mice.
Zhou HH1, Zhang L, Zhou QG, Fang Y, Ge WH. Neuroreport. 2016 Feb 10;27(3):160-5. doi: 10.1097/WNR.0000000000000516.
Common chemotherapeutic agents such as oxaliplatin often cause neuropathic pain during cancer treatment in patients. Such neuropathic pain is difficult to treat and responds poorly to common analgesics, which represents a clinical challenge. (+)-Borneol, a bicyclic monoterpene present in the essential oil of plants, is used for analgesia and anesthesia in traditional Chinese medicine. Although borneol has an antinociceptive effect on acute pain models, little is known about its effect on chemotherapy-induced neuropathic pain and its mechanism. We found that (+)-borneol exerted remarkable antihyperalgesic effects in a mouse model of oxaliplatin-induced neuropathic pain. In addition, (+)-borneol blocked the action of the transient receptor potential ankyrin 1 agonist in mechanical and cold stimulus tests. Repeated treatment with (+)-borneol did not lead to the development of antinociceptive tolerance and did not affect body weight and locomotor activity.
2.Antinociceptive activity of the essential oil from Artemisia ludoviciana.
Anaya-Eugenio GD1, Rivero-Cruz I1, Bye R2, Linares E2, Mata R3. J Ethnopharmacol. 2016 Feb 17;179:403-11. doi: 10.1016/j.jep.2016.01.008. Epub 2016 Jan 11.
ETHNOPHARMACOLOGICAL RELEVANCE: Aerial parts of Artemisia ludoviciana are widely used in Mexico for treating gastrointestinal disorders, painful complaints and diabetes.
3.Dittrichia graveolens (L.) Greuter Essential Oil: Chemical Composition, Multivariate Analysis, and Antimicrobial Activity.
Mitic V1, Stankov Jovanovic V2, Ilic M2, Jovanovic O2, Djordjevic A2, Stojanovic G2. Chem Biodivers. 2016 Jan;13(1):85-90. doi: 10.1002/cbdv.201500028.
The chemical composition and in vitro antimicrobial activities of Dittrichia graveolens (L.) Greuter essential oil was studied. Moreover, using agglomerative hierarchical cluster (AHC) and principal component analyses (PCA), the interrelationships of the D. graveolens essential-oil profiles characterized so far (including the sample from this study) were investigated. To evaluate the chemical composition of the essential oil, GC-FID and GC/MS analyses were performed. Altogether, 54 compounds were identified, accounting for 92.9% of the total oil composition. The D. graveolens oil belongs to the monoterpenoid chemotype, with monoterpenoids comprising 87.4% of the totally identified compounds. The major components were borneol (43.6%) and bornyl acetate (38.3%). Multivariate analysis showed that the compounds borneol and bornyl acetate exerted the greatest influence on the spatial differences in the composition of the reported oils. The antimicrobial activity against five bacterial and one fungal strain was determined using a disk-diffusion assay.
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CAS 464-43-7 (+)-Borneol

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