Boldine - CAS 476-70-0
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Boldine, an aporphine alkaloid extracted from the leaves and bark of P. boldus, potent antioxidant activity has been linked to anti-inflammatory, anti-pyretic, anti-diabetic, anti-atherogenic, anti-platelet, anti-tumor, UV-protective, and hepatoprotective effects.
Publictions citing BOC Sciences Products
  • >> More
Yellow to Brown Solid
5,6,6aS,7-tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol;(+)-(S)-Boldine 2,9-Dihydroxy-1,10-dimethoxyaporphine;
Soluble in DMSO
Store at -20 °C
Antioxidant and free-radical scavenging ability.
Quality Standard:
Enterprise standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Boiling Point:
529.3ºC at 760 mmHg
Melting Point:
162-164 ºC
1.29 g/cm3
Canonical SMILES:
1.Oxaliplatin analogues with carboxy derivatives of boldine with enhanced antioxidant activity.
Mellado M1, Jara C2, Astudillo D3, Villena J3, Reveco PG1, Thomet FA1. Bioinorg Chem Appl. 2015;2015:920143. doi: 10.1155/2015/920143. Epub 2015 Feb 28.
A new oxaliplatin analog [Pt(dach)(L5)] (1) was synthesized and characterized as a continuation of a study of the previously reported [Pt(dach)(L6)] (2), where dach = (1R,2R)-diaminocyclohexane, L5 = 3-carboxyboldine, and L6 = 3-carboxypredicentrine. Compounds 1 and 2 exhibited a substantially enhanced antioxidant activity compared to oxaliplatin (130 and 30 times for 1 and 13 and 4 times for 2 using the DPPH and FRAP assays, resp.). In addition, 1 and 2 exhibited cytotoxic activity in the same range as oxaliplatin toward the two human tumor cell lines (MCF-7 and HT-29) studied and two to four times lower activity in the human colon nontumor cell line (CCD-841). Preadministration of L5 or L6 to the colon tumor (HT-29) and the colon nontumor (CCD-841) cell lines prior to oxaliplatin addition increased the viability of the nontumor cell line to a greater extent than that of the tumor cell line.
2.[Alkaloids from roots and stems of Litsea cubeba].
Zhang SY, Guo Q, Cao Y, Zhang Y, Gao XL, Tu PF, Chai XY. Zhongguo Zhong Yao Za Zhi. 2014 Oct;39(20):3964-8.
A phytochemical investigation on the roots and stems of Litsea cubeba led to the isolation of seven isoquinolone alkaloids. By spectroscopic analysis and comparison of their 1H and 13C-NMR data with those in literatures, these alkaloids were identified as (+)-norboldine (1), (+)-boldine (2), (+)-reticuline (3), (+)-laurotetanine (4), (+)-isoboldine (5), (+)-N-methyl-laurotetanine (6), and berberine (7), respectively. Among them, 7 was isolated from the genus for the first time. The evaluation of these compounds showed weak anti-inflammatory activity against NO production in RAW 267.4 and BV-2 cells.
3.Boldine suppresses dextran sulfate sodium-induced mouse experimental colitis: NF-κB and IL-6/STAT3 as potential targets.
Pandurangan AK1, Mohebali N1, Hasanpourghadi M1, Looi CY1, Mustafa MR1, Mohd Esa N2,3. Biofactors. 2016 Feb 19. doi: 10.1002/biof.1267. [Epub ahead of print]
Ulcerative colitis (UC) is a nonspecific inflammatory disorder characterized by oxidative and nitrosative stress, leucocyte infiltration, and upregulation of inflammatory mediators. Boldine is an alkaloid compound found in Boldo tree, with multiple pharmacological actions, mainly anti-inflammatory, antioxidant, antitumor, and immunomodulatory activities. Hence, the effect of boldine for its anti-inflammatory properties against dextran sulfate sodium (DSS)-induced UC in BALB/c mice was studied. Administration of boldine to DSS-induced mice protects colon damage by reduced disease activity index, spleen weight, and increased colon length. Also administration of boldine showed a reduction in the activity of myeloperoxidase (MPO) and CD 68+ expression. Boldine reduced the colon damage, with significant reductions in both the extent and the severity of the inflammation as well as in crypt damage and leukocyte infiltration in the mucosa. Analysis in vivo showed clear decrease in the production of tumor necrosis factor (TNF)-α, Interleukin (IL)-6, IL-17, and signal transducer and activator of transcription-(p-STAT3)Y705 with nuclear factor (p65-NF-κB) production being reduced significantly.
4.Screening of the Pan-African natural product library identifies ixoratannin A-2 and boldine as novel HIV-1 inhibitors.
Tietjen I1, Ntie-Kang F2, Mwimanzi P3, Onguéné PA4, Scull MA5, Idowu TO6, Ogundaini AO6, Meva'a LM4, Abegaz BM7, Rice CM5, Andrae-Marobela K8, Brockman MA9, Brumme ZL10, Fedida D11. PLoS One. 2015 Apr 1;10(4):e0121099. doi: 10.1371/journal.pone.0121099. eCollection 2015.
The continued burden of HIV in resource-limited regions such as parts of sub-Saharan Africa, combined with adverse effects and potential risks of resistance to existing antiretroviral therapies, emphasize the need to identify new HIV inhibitors. Here we performed a virtual screen of molecules from the pan-African Natural Product Library, the largest collection of medicinal plant-derived pure compounds on the African continent. We identified eight molecules with structural similarity to reported interactors of Vpu, an HIV-1 accessory protein with reported ion channel activity. Using in vitro HIV-1 replication assays with a CD4+ T cell line and peripheral blood mononuclear cells, we confirmed antiviral activity and minimal cytotoxicity for two compounds, ixoratannin A-2 and boldine. Notably, ixoratannin A-2 retained inhibitory activity against recombinant HIV-1 strains encoding patient-derived mutations that confer resistance to protease, non-nucleoside reverse transcriptase, or integrase inhibitors.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

(CAS: 305821-96-9)

CP-472555 is an effective Glucocorticoid receptor agonist and probably has steroid-like anti-inflammatory properties with anti-GR and anti-obesity activity in a...

CAS 3562-99-0 Menbutone

(CAS: 3562-99-0)

An oxobutyric acid derivative which is used for stimulating gastro-intestinal function.

CAS 56-04-2 Methylthiouracil

(CAS: 56-04-2)

Methylthiouracil is an antithyroid preparation.The drug acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland.

CAS 104-46-1 cis-Anethol

(CAS: 104-46-1)

Anethole, a widespread plant extract, could be used in various areas like foods and drugs as a flavoring agent. It might also block neuronal excitability.

CAS 195514-80-8 AP20187

(CAS: 195514-80-8)

Systemic AP20187 administration results in time-dependent LFv2IRE tyrosine phosphorylation and activation of the insulin signaling pathway in both liver and mus...

CAS 486-62-4 Ononin

(CAS: 486-62-4)

Ononin is an isoflavonoid from Ononis natrix L, can inhibit the growth of pathogen.

CAS 133825-80-6 ATR-101

(CAS: 133825-80-6)

ATR-101 is a selective Acetyl CoA C-acetyltransferase inhibitor. ATR-101 is uniquely distributed to adrenal tissues and inhibition of adrenal ACAT1 by ATR-101 d...

CAS 19666-76-3 Panaxadiol

(CAS: 19666-76-3)

Panaxadiol, a triterpenoid compound extracted from roots of Panax ginseng C, a novel antitumor agent that regulates of cell cycle transition and induces apoptot...

CAS 119793-66-7 Propionyl-L-Carnitine HCl

Propionyl-L-Carnitine HCl
(CAS: 119793-66-7)

The hydrochloride salt form of L-Propionylcarnitine which has been found to be related to mitochondrial metabolism so that could be used in the treatment deteri...

CAS 52705-93-8 Ginsenoside Rd

Ginsenoside Rd
(CAS: 52705-93-8)

Ginsenoside Rf, extracted from the traditional Chinese herb ginseng used as an aldose reductase inhibitor and exert anti-inflammatory and immunomodulatory activ...

CAS 53963-43-2 Ginsenoside F1

Ginsenoside F1
(CAS: 53963-43-2)

Ginsenoside F1, a metabolite of ginsenoside Rg1, which is used as an aldose reductase inhibitor and my exert anti-inflammatory and immunomodulatory activity.

CAS 299-28-5 Gluconate Calcium

Gluconate Calcium
(CAS: 299-28-5)

Gluconate Calcium is an calcium supplement used in crop pesticide formulations and also in the treatment of too little calcium in the blood.

CAS 471-66-9 Boswellic acid

Boswellic acid
(CAS: 471-66-9)

α-Boswellic acid is the principal constitutents of frankincense (olibanum). It is a specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.

CAS 1391054-02-6 Vigabatrin Hydrochloride

Vigabatrin Hydrochloride
(CAS: 1391054-02-6)

A novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic.

(CAS: 1818885-28-7)

ARV-825, a BRD4 inhibitor, has extensive anti-AML activity and modulates tumor microenvironment and metabolism to overcome stromamediated drug resistance. DC50...

(CAS: 923562-23-6)

STK321130 is potent FLT3 inhibitor with IC50 value of less than 1 μM.

CAS 113962-61-1 Cgp 13231

Cgp 13231
(CAS: 113962-61-1)

Cgp 13231 is the N-oxide metabolite of amocarzine

CGP 43182
(CAS: 150379-37-6)

CGP 43182, a dioxaspiro compound, has been found to a IIA sPLA2 inhibitor that could have potential anti-inflammatory effect and also in influencing the synergi...

CAS 183675-82-3 Penthiopyrad

(CAS: 183675-82-3)

Penthiopyrad is a novel fungicide used in the protection of crops.

CAS 23233-88-7 Brotianide

(CAS: 23233-88-7)

Brotianide, with anti-fasciolidal activity, is an anthelminthic drug for the treatment of severe infections on animals to remove larvae.

Chemical Structure

CAS 476-70-0 Boldine

Quick Inquiry

Verification code

Featured Items