BMT-145027 - CAS 2018282-44-3
Category: Inhibitor
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Molecular Formula:
C23H14ClF3N4
Molecular Weight:
438.83
COA:
Inquire
Targets:
mGluR
Description:
BMT-145027 is a potent mGluR5 PAM without inherent agonist activity with an EC50 of 47 nM. BMT-145027 is a non-MPEP site PAM to demonstrate in vivo efficacy.
Brife Description:
An mGluR5 positive allosteric modulator
Synonyms:
BMT-145027; BMT 145027; BMT145027; 3-[4-chloro-3-(trifluoromethyl)phenyl]-4-cyclopropyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile
Solubility:
DMSO: ≥2.4 mg/mL (need ultrasonic and warming)
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
653.2±55.0 ℃ at 760 Torr
Density:
1.51±0.1 g/cm3
InChIKey:
UXLUNMKSQUMWLH-UHFFFAOYSA-N
InChI:
1S/C23H14ClF3N4/c24-17-9-8-14(10-16(17)23(25,26)27)21-19-18(12-6-7-12)15(11-28)20(29-22(19)31-30-21)13-4-2-1-3-5-13/h1-5,8-10,12H,6-7H2,(H,29,30,31)
Canonical SMILES:
C1CC1C2=C(C(=NC3=NNC(=C23)C4=CC(=C(C=C4)Cl)C(F)(F)F)C5=CC=CC=C5)C#N
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CAS 2018282-44-3 BMT-145027

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