|Description||BMS711939 is a selective and potent peroxisome proliferator-activated receptor α(PPARα) agonist with EC50 value of 4 nM for human PPARα. It is >1000-fold selectivity vs human PPARγ with EC50 value of 4.5 μM and PPARδ with EC50 value of > 100 μM in PPAR-GAL4 transactivation assays. It shows excellent in vivo efficacy and safety profiles in preclinical studies. It was chosen for further preclinical evaluation.|
|Synonyms||Glycine, N-((5-((2-(4-chlorophenyl)-5-methyl-4-oxazolyl)methoxy)-2-fluorophenyl)methyl)-N-(methoxycarbonyl)-; BMS-711939;2-[[5-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]-2-fluorophenyl]methyl-methoxycarbonylamino]acetic acid|
|Solubility||10 mM in DMSO|
|Application||BMS711939 was chosen for further preclinical evaluation.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Melting Point||650.1±65.0 °C | Condition: Press: 760 Torr|
|Density||1.379±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
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