|Description||BMS561392 is a tumor necrosis factor-alpha (TNF alpha) converting enzyme inhibitor. It has the potential treatment of diseases characterized by overproduction of TNF alpha, such as rheumatoid arthritis (RA). It was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated.|
|Solubility||Soluble in DMSO, not in water|
|Application||BMS561392 has the potential treatment of diseases characterized by overproduction of TNF alpha, such as rheumatoid arthritis (RA).|
|Quality Standard||In-house standard|
|Density||1.253±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||BMS561392 was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated.|
Lenalidomide is a TNF-α secretion inhibitor.
Beta-mangostin, a natural product extracted from the fruits of Garcinia mangostana, can reduced the levels of TNF-α and IL-1β in peritoneal fluid.
C 87 is a TNF-α inhibitor (Kd = 110 nM for hTNF-α). It was shown to inhibit TNF-α-induced cytotoxicity in L929 fibroblast cells, attenuate inflammation and incr...
Pomalidomide is an analog of thalidomide, a TNF-α production inhibitor. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibitin...
GW-3333 is a dual inhibitors of tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) and matrix metalloproteinases.
SPD 304 a cell-permeable inhibitor of tumor necrosis factor-α (TNFα, IC50 = 22 μM), which is a modulator of inflammation conditions such as rheumatoid arthritis...
DCVC has been found to influence sort of cytokines release stimulated by pathogen.
Lenalidomide is an analog of thalidomide, a TNF-α production inhibitor. Lenalidomide can be utilized in PROTAC as an E3 ligase ligand for targeting cereblon, in...
Bioymifi is a potent and selective death receptor 5 (DR5) activator. Bioymifi works by mimicking the ability of TRAIL to stimulate clustering of DR5, triggering...
Ginsenoside Rg5, a main constituent isolated from red ginseng, exhibits anti-inflammatory property as in LPS-stimulated alveolar macrophages it inhibited the ex...
Roquinimex, also known as LS 2616 and FCF89 (brande name: Linomide), is a quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits en...
BMS561392 is a tumor necrosis factor-alpha (TNF alpha) converting enzyme inhibitor. It has the potential treatment of diseases characterized by overproduction o...
A potent, orally active and dual inhibitor of phosphodiesterase 4 (PDE4) (IC50= 1.1 μM) and tumor necrosis factor-α (TNF-α) (IC50= 2.5 μM).
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
Magnolol is a bioactive lignin found in Magnolia officinalis and acts as a TNF-α and nitric oxide (NO) inhibitor. It exhibits potential therapeutic effect on an...
Necrostatin 2 is a potent necroptosis inhibitor. It is a potent in vitro necroptosis inhibitors and is also efficacious in an animal model of ischemic stroke.
CPI-1189 is an inhibitor of TNF-α release with the potential use to treat sciatica and postherpetic neuralgia.
Hispidol ((Z)-Hispidol) inhibits TNF-α induced adhesion of monocytes to colon epithelial cells (IC50= 0.50 µM) and is a potential therapeutic for inflammatory b...
Lenalidomideis a derivative of thalidomide introduced in 2004. Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.
Necrostatin 2 S enantiomer
Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin, which is a potent necroptosis inhibitor.