|Description||BMS561392 is a tumor necrosis factor-alpha (TNF alpha) converting enzyme inhibitor. It has the potential treatment of diseases characterized by overproduction of TNF alpha, such as rheumatoid arthritis (RA). It was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated.|
|Synonyms||BMS-561392; BMS561392; BMS 561392; DPC-333; DPC 333; DPC333. (αR,3R)-3-Amino-N-hydroxy-α-(2-methylpropyl)-3-[4-[(2-methyl-4-quinolinyl)methoxy]phenyl]-2-oxo-1-pyrrolidineacetamide;BMS-561392;DPC-333;(2R)-2-[(3R)-3-amino-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]-N-hyd|
|Solubility||Soluble in DMSO, not in water|
|Application||BMS561392 has the potential treatment of diseases characterized by overproduction of TNF alpha, such as rheumatoid arthritis (RA).|
|Quality Standard||In-house standard|
|Density||1.253±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||BMS561392 was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated.|
A potent, orally active and dual inhibitor of phosphodiesterase 4 (PDE4) (IC50= 1.1 μM) and tumor necrosis factor-α (TNF-α) (IC50= 2.5 μM).
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