Taladegib binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling.
Cyclopamine (11-deoxojervine) is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from th...
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can ...
MS0022 is a SMO antagonist. It showed effective Hh signaling pathway inhibition at the level of SMO in the low nM range, and Hh pathway inhibition downstream of...
MK-4101 is a potent and selective SMO Inhibitor of the Hedgehog Pathway with anti-tumor activity. MK-4101 targets the Hh pathway in tumor cells, showing the max...
This active molecular is a Smoothened (Smo) antagonist with potential antitumor activity. LEQ506 selectively binds to the Hedgehog（Hh） ligand cell surface recep...
Purmorphamine, under the IUPAC name 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine, is a cell-permeable 6,9-trisubstituted pur...
Sonidegib, also known as, erismodegib (LDE225, NVP-LDE225) is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic ac...
MRT-92 HCl salt
MRT-92 is a selective Smoothened (Smo) receptor inhibitor. It shows subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibit...
MRT-83 is a Smoothened (Smo) antagonist. It can block Hedgehog (Hh) signaling in various assays. MRT-83 can also inhibit Bodipy-cyclopamine binding to human and...
SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); sag antagonizes cyclopamine action at the Smo receptor.
This active molecular is a novel potent Smoothened antagonist. MRT-83 blocks Hedgehog (Hh) signaling in various assays and IC50 can be in nmol range, showing gr...
Glasdegib, als known as PF-04449913, is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic act...