BMS-791325 HCl - CAS 958002-36-3
Catalog number:
958002-36-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Description:
BMS-791325 is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50) below 28 nM. In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. BMS-791325 was found to have distinguishing antiviral, safety, and pharmacokinetic properties that resulted in its selection for clinical evaluation. BMS-791325 is currently under Phase III trials.
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Appearance:
solid powder
Synonyms:
BMS-791325; BMS791325; BMS 791325.
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CAS 958002-36-3 BMS-791325 HCl

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