BMS-791325 HCl - CAS 958002-36-3
Catalog number: B0084-462269
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C36H46ClN5O5S
Molecular Weight:
696.304
COA:
Inquire
Targets:
NS5B polymerase
Description:
BMS-791325 HCl is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50 < 28 nM). In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. BMS-791325 was found to have distinguishing antiviral, safety, and pharmacokinetic properties that resulted in its selection for clinical evaluation. BMS-791325 is currently under Phase III trials.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-462269 5 mg $399 In stock
Bulk Inquiry
Brife Description:
HCV NS5B inhibitor
Purity:
> 98%
Related CAS:
958002-33-0 (free base)
Synonyms:
Beclabuvir hydrochloride
MSDS:
Inquire
InChIKey:
IHXVACFNNPBRLK-OZSFMWOHSA-N
InChI:
InChI=1S/C36H45N5O5S.ClH/c1-38(2)47(44,45)37-34(42)23-10-14-28-31(16-23)40-21-36(35(43)41-24-11-12-25(41)20-39(3)19-24)18-30(36)29-17-26(46-4)13-15-27(29)33(40)32(28)22-8-6-5-7-9-22;/h10,13-17,22,24-25,30H,5-9,11-12,18-21H2,1-4H3,(H,37,42);1H/t24-,25+,30-,36-;/m0./s1
Canonical SMILES:
CN1CC2CCC(C1)N2C(=O)C34CC3C5=C(C=CC(=C5)OC)C6=C(C7=C(N6C4)C=C(C=C7)C(=O)NS(=O)(=O)N(C)C)C8CCCCC8.Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related NS5B polymerase Products


CAS 958002-36-3 BMS-791325 HCl

BMS-791325 HCl
(CAS: 958002-36-3)

BMS-791325 HCl is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recom...

HCV371
(CAS: 675184-27-7)

HCV371 is a potent and selective HCV NS5B polymerase inhibitor. It binds the NS5B with an apparent dissociation constant of 150 nM, which leads to high selectiv...

Lomibuvir
(CAS: 1026785-55-6)

Lomibuvir is an nonnucleoside NS5B polymerase inhibitor. It inhibits the 1b/Con1 HCV subgenomic replicon. It binds to the HCV polymerase with dissociation const...

Chemical Structure

CAS 958002-36-3 BMS-791325 HCl

Quick Inquiry

Verification code

Featured Items