BMS-582949 hydrochloride - CAS 912806-16-7
Catalog number:
912806-16-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H27ClN6O2
Molecular Weight:
442.94
COA:
Inquire
Targets:
p38 MAPK
Description:
BMS-582949 hydrochloride is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 of 13 nM. It displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases including serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms. It is a weak inhibitor of CYP3A4, with an IC50 value ranging from 18 to 40 μM based in multiple tests. It does not significantly inhibit cytochrome P450 isozymes 1A2, 2C9, 2C19, and 2D6 in vitro. It exhibited oral bioavailability values of 90% and 60% in mice and rats, respectively. It is currently under Phase II clinical trials for the treatment of inflammatory diseases.
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Purity:
>98%
Appearance:
Solid powder
Synonyms:
BMS 582949 hydrochloride;4-((5-((Cyclopropylamino)carbonyl)-2-methylphenyl)amino)-5-methyl-n-propylpyrrolo(2,1-f)(1,2,4)triazine-6-carboxamide
Solubility:
DMSO: > 35 mg/mL
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
BMS-582949 hydrochloride is used for the treatment of inflammatory diseases.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
BIYQUPNVBIOJIY-UHFFFAOYSA-N
InChI:
InChI=1S/C22H26N6O2.ClH/c1-4-9-23-22(30)17-11-28-19(14(17)3)20(24-12-25-28)27-18-10-15(6-5-13(18)2)21(29)26-16-7-8-16;/h5-6,10-12,16H,4,7-9H2,1-3H3,(H,23,30)(H,26,29)(H,24,25,27);1H
Canonical SMILES:
CCCNC(=O)C1=CN2C(=C1C)C(=NC=N2)NC3=C(C=CC(=C3)C(=O)NC4CC4)C.Cl
Current Developer:
BMS-582949 hydrochloride is currently under Phase II clinical trials.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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