1.A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues.
Dhar TG1, Guo J, Shen Z, Pitts WJ, Gu HH, Chen BC, Zhao R, Bednarz MS, Iwanowicz EJ. Org Lett. 2002 Jun 13;4(12):2091-3.
[structure: see text] A modified approach to the synthesis of 2-(N-aryl)-1,3-oxazoles, employing an optimized iminophosphorane/heterocumulene-mediated methodology, and its application to the synthesis of BMS-337197, a potent inhibitor of IMPDH, are described.