|Description||BMS-214662 mesylate is a potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cβ.|
|Appearance||Light Yellow Solid|
|Synonyms||(R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-Benzodiazepine-7-carbonitrile monohydrochloride, (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine mesylate|
|Solubility||Soluble in DMSO|
|Storage||Store at -20 °C|
|Application||A potent and selective inhibitor of farnesyltransferase|
|Quality Standard||Enterprise standard|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.|
|Current Developer||Bristol-Myers Squibb|
N-Acetyl-β-Asp-Glu is a peptide neurotransmitter and the third-most-prevalent neurotransmitter in the mammalian nervous system.
20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid is a potent vasoconstrictor produced in vascular smooth muscle cells. Its EC50 value is < 10 nM. It is a cytoch...
Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties.
Carcinoembryonic antigen (CEA), a substance found on the surface of some cells, is a tumor marker in lung cancer.
p53 and MDM2 proteins-interaction-inhibi
p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins.
D-Luciferin sodium salt
Sodium salt form of D-Luciferin, derived from the luciferase gene of photinus pyralis, is commonly used as a reporter gene for studying transcriptional regulati...
Iobenguane is used in a scintigraphy method called Metaiodobenzylguanidine (MIBG) scan as a radiopharmaceutical. It can localize to adrenergic tissue and thus c...
BMS-363131 is very potent inhibitor of human tryptase with inhibitory activity against bovine trypsin
CB 3703 is an inhibitor of hydrofolate reductase.
Hybendazole hydrochloride is a synthetic bio-active chemical.
FR-182980, a pyridine derivative, has been found to be a sterol O-acyltransferase inhibitor and was once studied in hypercholesterolaemia.
This active molecular, also known as GSK-557296B is a selective, sub-nanomolar (Ki=0.13 nM) oxytocin receptor antagonist with more than 30000-fold selectivity o...
Butylhydroxyanisole, also called as AMIF 72, Nipantiox 1 F or Butyl Methoxyphenol, with antioxidative property it is used as a food additive preservative.
Ginsenoside Rc, a sort of triterpene saponin, is extracted from ginseng and has been found to be antioxidative, anti-aging and has sorts of other properties. It...
An alkaloid FR 5 from Fritillaria thunbergii. An angiotensin converting enzyme inhibitory steroidal alkaloid. It is a commonly used antitussive and expectorant ...
W-54011 is a potent, specific high affinity C5a receptor antagonist (Ki = 2.2 nM).
Niludipine, a safe antianginal Ca2+-antagonist, is a drug with broad effectiveness for various types of angina pectoris.
4-O-β-D-Glucosyl-5-O-methyllvisamminol is a natural product isolated from the roots of Saposhnikovia divaricata (Turcz.) Schischk. It is a novel epigenetic supp...
FR-78844 is used as a bone resorption antagonist.
Melphalan flufenamide, is a melphalan prodrug in which the alkylating agent melphalan is bound to flufenamide, alkylates DNA at the N7 position of guanine resid...