BMS-193885 - CAS 186185-03-5
Catalog number: 186185-03-5
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Neuropeptide Y receptor
BMS-193885 is a potent and selective neuropeptide Y1 receptor antagonist with IC50= 5.9nM, Ki = 3.3 nM. BMS-193885 displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively.
Solid powder
dimethyl 4-[3-[3-[4-(3-methoxyphenyl)piperidin-1-yl]propylcarbamoylamino]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; BMS 193885; 679839-66-8BMS-193885; BMS193885; BMS 193885
Canonical SMILES:
1.Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist.
Antal-Zimanyi I1, Bruce MA, Leboulluec KL, Iben LG, Mattson GK, McGovern RT, Hogan JB, Leahy CL, Flowers SC, Stanley JA, Ortiz AA, Poindexter GS. Eur J Pharmacol. 2008 Aug 20;590(1-3):224-32. doi: 10.1016/j.ejphar.2008.06.032. Epub 2008 Jun 12.
Treatment of obesity is still a large unmet medical need. Neuropeptide Y is the most potent orexigenic peptide in the animal kingdom. Its five cloned G-protein couple receptors are all implicated in the regulation of energy homeostasis evidenced by overexpression or deletion of neuropeptide Y or its receptors. Neuropeptide Y most likely exerts its orexigenic activity via the neuropeptide Y(1) and neuropeptide Y(5) receptors, although the involvement of the neuropeptide Y(2) and neuropeptide Y(4) receptors are also gaining importance. The lack of potent, selective, and brain penetrable pharmacologic agents at these receptors made our understanding of the modulation of food intake by neuropeptide Y-ergic agents elusive. BMS-193885 (1,4-dihydro-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino] carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid, dimethyl ester) is a potent and selective neuropeptide Y(1) receptor antagonist.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Neuropeptide Y receptor Products

CAS 313988-89-5 [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide

(CAS: 313988-89-5)

A Y5 receptor-selective agonist (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki...

CAS 123583-37-9 Peptide YY (3-36) human

Peptide YY (3-36) human
(CAS: 123583-37-9)

Peptide YY (3-36) human, a short (36-amino acid) peptide released by cells in the ileum and colon in response to feeding, is a NPY Y2 receptor agonist. PYY (3-3...

CAS 125580-28-1 [Leu31,Pro34]-Neuropeptide Y (porcine)

[Leu31,Pro34]-Neuropeptide Y (porcine)
(CAS: 125580-28-1)

[Leu31,Pro34]-Neuropeptide Y (porcine) is a high affinity neuropeptide Y Y1 receptor agonist (Ki = 0.54 nM).

CAS 132699-73-1 [Leu31,Pro34]-Neuropeptide Y (human, rat)

[Leu31,Pro34]-Neuropeptide Y (human, rat
(CAS: 132699-73-1)

[Leu31,Pro34]-Neuropeptide Y (human, rat) is a high affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM).

CAS 90880-35-6 Neuropeptide Y (human, rat)

Neuropeptide Y (human, rat)
(CAS: 90880-35-6)

Neuropeptide Y (human, rat) is a widely distributed endogenous neuropeptide involved in the control of food intake, sexual behavior and blood pressure. NPY has ...

CAS 158859-98-4 GR 231118

GR 231118
(CAS: 158859-98-4)

GR 231118 is a potent neuropeptide Y (NPY) Y1 receptor antagonist (pA2 = 10 and 10.5 at rY1 and hY1 receptors, respectively) and an NPY Y4 receptor agonist (pEC...

Neuropeptide Y (scrambled)

Neuropeptide Y (scrambled) is the control peptide for neuropeptide Y (NPY). Neuropeptide Y is a widely distributed endogenous neuropeptide involved in the contr...

CAS 447405-11-0 FR252384

(CAS: 447405-11-0)

FR252384 is novel potent antagonists of human neuropeptide Y-Y5 receptor (IC50= 2.3 nM).

Chemical Structure

CAS 186185-03-5 BMS-193885

Quick Inquiry

Verification code

Featured Items