BMS-191095 - CAS 166095-21-2
Catalog number:
166095-21-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H21ClN4O2
Molecular Weight:
408.88
COA:
Inquire
Targets:
Potassium Channel
Description:
BMS-191095 is an activators that has selective effects on mitochondrial ATP-sensitive potassium (mitoKATP) channels. in vitro: induces mitochondrial-depolarization and vasodilation
Publictions citing BOC Sciences Products
  • >> More
Appearance:
Solid powder
Synonyms:
(3R,4S)-4-[4-chloro-N-(1H-imidazol-2-ylmethyl)anilino]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromene-6-carbonitrile BMS-191095 CHEMBL11594 SCHEMBL8896325 ZINC3821976 BDBM50409914
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -63℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Quantity:
Grams-Kilos
Boiling Point:
649.4±55.0 °C | Condition: Press: 760 Torr
Density:
1.39±0.1 g/cm3
InChIKey:
SMIKIPXIDLITMP-LEWJYISDSA-N
InChI:
1S/C22H21ClN4O2/c1-22(2)21(28)20(17-11-14(12-24)3-8-18(17)29-22)27(13-19-25-9-10-26-19)16-6-4-15(23)5-7-16/h3-11,20-21,28H,13H2,1-2H3,(H,25,26)/t20-,21+/m0/s1
Canonical SMILES:
CC1(C(C(C2=C(O1)C=CC(=C2)C#N)N(CC3=NC=CN3)C4=CC=C(C=C4)Cl)O)C
1.ROS-independent preconditioning in neurons via activation of mitoK(ATP) channels by BMS-191095.
Gáspár T1, Snipes JA, Busija AR, Kis B, Domoki F, Bari F, Busija DW. J Cereb Blood Flow Metab. 2008 Jun;28(6):1090-103. doi: 10.1038/sj.jcbfm.9600611. Epub 2008 Jan 30.
Previously, we have shown that the selective mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel opener BMS-191095 (BMS) induces neuronal preconditioning (PC); however, the exact mechanism of BMS-induced neuroprotection remains unclear. In this study, we have identified key components of the cascade resulting in delayed neuronal PC with BMS using isolated rat brain mitochondria and primary cultures of rat cortical neurons. BMS depolarized isolated mitochondria without an increase in reactive oxygen species (ROS) generation and induced rapid phosphorylation of Akt and glycogen synthase kinase-3beta. Long-term (3 days) treatment of neurons with BMS resulted in sustained mitochondrial depolarization, decreased basal ROS generation, and elevated ATP levels. This treatment also elicited almost complete protection against glutamate excitotoxicity, which could be abolished using the phosphoinositide 3-kinase (PI3K) inhibitor wortmannin, but not with the superoxide dismutase (SOD) mimetic M40401.
2.The cytoprotective action of the potassium channel opener BMS-191095 in C2C12 myoblasts is related to the modulation of calcium homeostasis.
Malinska D1, Kulawiak B, Wrzosek A, Kunz WS, Szewczyk A. Cell Physiol Biochem. 2010;26(2):235-46. doi: 10.1159/000320523. Epub 2010 Aug 24.
BMS-191095 is an opener of the mitochondrial ATP-regulated potassium channel, which has been shown to provide cytoprotection in models of ischemia-reperfusion induced injury in various tissues. This study aimed at checking the protective action of BMS-191095 under the conditions of oxidative stress or disruption of intracellular calcium homeostasis.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Potassium Channel Products


Celikalim
(CAS: 124916-54-7)

Celikalim is s ATP-sensitive potassium channel agonist originated by Wyeth. It increases K+ outward flux in dog and human airway smooth muscle. But clinical tri...

CAS 289905-88-0 TRAM-34

TRAM-34
(CAS: 289905-88-0)

TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM).

RPR-260243
(CAS: 668463-35-2)

RPR-260243 is a selective activator of the Human Ether-ago-go-Related Gene (hERG) (IC50 = 58 nM).

CAS 36167-63-2 Halofantrine Hydrochloride

Halofantrine Hydrochloride
(CAS: 36167-63-2)

Halofantrine is a blocker of delayed rectifier potassium current via the inhibition of hERG channel used to treat malaria.

CAS 56995-20-1 Flupirtine

Flupirtine
(CAS: 56995-20-1)

Flupirtine is a selective neuronal potassium channel opener act as an Analgesic, having substituted pyridine with central analgesic properties.

ML-365
(CAS: 947914-18-3)

ML-365 is a potent and novel selective small molecule inhibitor of TASK1 with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiol...

CAS 207844-01-7 Mitiglinide calcium hydrate

Mitiglinide calcium hydrate
(CAS: 207844-01-7)

Mitiglinide calcium hydrate, a derivative of benzylsuccinic acid, is a highly selective KATP channel antagonist.

CAS 1951-25-3 Amiodarone

Amiodarone
(CAS: 1951-25-3)

Amiodarone, an iodine-rich benzofuran derivative, as a vaughan-Williams Class III antiarrhythmic agent it is an ATP-sensitive potassium channel inhibitor (IC50=...

CAS 50679-08-8 Terfenadine

Terfenadine
(CAS: 50679-08-8)

Terfenadine is a potent open-channel blocker of hERG (IC50=204 nM), formerly used for the treatment of allergic conditions.

CAS 113559-13-0 E-4031

E-4031
(CAS: 113559-13-0)

E-4031, a benzenesulfonamide derivative, could be used as a Class III antiarrhythmic agent due to its effect of blocking the ERG potassium channels.

CAS 51940-44-4 Pipemidic acid

Pipemidic acid
(CAS: 51940-44-4)

Pipemidic acid is a synthetic quinolone antibiotic agent as a ATP-sensitive K+ channel blocker.

CAS 1260141-27-2 TAK438

TAK438
(CAS: 1260141-27-2)

TAK-438 is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretio...

CAS 21187-98-4 Gliclazide

Gliclazide
(CAS: 21187-98-4)

Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.

MK 499
(CAS: 150481-98-4)

MK 499, also know as L706000, has been found to be a potassium channel antagonist that has been once studied the activity in the treatment of arrhythmias. The P...

CAS 448895-37-2 NS 1643

NS 1643
(CAS: 448895-37-2)

NS 1643 is human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM)

GYKI-16638
(CAS: 778564-77-5)

GYKI-16638 is Potassium channel and Sodium channel antagonist originated by Nonindustrial source. It is a novel antiarrhythmic agent.

CAS 134017-78-0 U89232

U89232
(CAS: 134017-78-0)

U89232, a cardioselective cyanoguanidine analog of cromakalim, appears to be a cardioselective KATP channel opener.

CAS 94535-50-9 Levcromakalim

Levcromakalim
(CAS: 94535-50-9)

LevCromakalim is an ATP-sensitive K+channel(KATP) activator used in the management of hypertension in diabetes mellitus.

CAS 152802-84-1 KRN4884

KRN4884
(CAS: 152802-84-1)

KRN4884, a synthesized 3-pyridine derivative, shows a long-lasting antihypertensive effect based on its potent potassium channel-opening action. The long-lastin...

BMS 180448
(CAS: 144264-47-1)

BMS 180448 is a prototype mitochondrial ATP-sensitive K+ channel stimulant. The cardioprotective effects of BMS-180448 against I/R heart injury may result from ...

Chemical Structure

CAS 166095-21-2 BMS-191095

Quick Inquiry

Verification code

Featured Items