BMS 182874 Hydrochloride - CAS 1215703-04-0
Catalog number: 1215703-04-0
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C17H20ClN3O3S
Molecular Weight:
381.88
COA:
Inquire
Targets:
Endothelin Receptor
Description:
This active molecular is a selective non-peptide Endothelin ETA receptor antagonist. It displays more than 1000-fold selectivity over ETB receptors (Ki of 48 nM for ETA receptors and >50 μM for ETB). BMS 182874 displays ET-1 inhibitory efficacy in vivo and vitro and it also inhibits ET-1-induced longitudinal muscle contraction in vitro. In 2006, BMS 182874 for coronary disorders and hypertension were discontinued in USA.
Purity:
98%
Appearance:
White to beige powder
Synonyms:
BMS 182874; BMS-182874; BMS182874; BMS 182874 HCl; BMS 182874 hydrochloride; 5-(dimethylamino)-N-(3,4-dimethylisoxazol-5-yl)naphthalene-1-sulfonamide hydrochloride
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
coronary disorders and hypertension
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Canonical SMILES:
CC1=C(NS(=O)(C2=CC=CC3=C2C=CC=C3N(C)C)=O)ON=C1C.Cl
Current Developer:
Originator:Bristol-Myers Squibb
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Endothelin Receptor Products


CAS 167256-08-8 Enrasentan

Enrasentan
(CAS: 167256-08-8)

Enrasentan, an indene derivative, has been found to be an endothelin receptor antagonist that was once studied in reperfusion injury and heart failure therapy.

CAS 157659-79-5 SB-209670

SB-209670
(CAS: 157659-79-5)

SB-209670 has been found to be an endothelin receptor antagonist that was once studied against arrhythmias and hypertension.

CAS 157212-55-0 Bosentan Hydrate

Bosentan Hydrate
(CAS: 157212-55-0)

Bosentan inhibits the presser response to big ET-1 both after i.v. and oral administration, with a long duration of action and no intrinsic agonist activity.

CAS 169679-53-2 T-0201

T-0201
(CAS: 169679-53-2)

T-0201 has been found to be an Endothelin A receptor antagonist that could be used as as anti-ischaemic agent and was once studied in heart failure and pulmonar...

CAS 121204-87-3 [Ala1,3,11,15]-Endothelin

[Ala1,3,11,15]-Endothelin
(CAS: 121204-87-3)

[Ala1,3,11,15]-Endothelin is a selective ETB endothelin receptor agonist (IC50 = 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors, respect...

CAS 177036-94-1 Ambrisentan

Ambrisentan
(CAS: 177036-94-1)

Ambrisentan, a highly selective antagonist of the endothelin-1 type A receptor with IC50 of 18 nM, is indicated for the treatment of pulmonary arterial hyperten...

CAS 121695-87-2 Sarafotoxin S6c

Sarafotoxin S6c
(CAS: 121695-87-2)

Sarafotoxin S6c is a highly selective ETB endothelin receptor agonist (Ki = 0.29 and 28000 nM at ETB and ETA receptors, respectively).

CAS 195529-54-5 A-192621

A-192621
(CAS: 195529-54-5)

A-192621 is a selective antagonist at endothelin ETB receptor with more effective than IRL-2500 in blocking IRL-1620-induced vasoconstriction, but both augmente...

Chemical Structure

CAS 1215703-04-0 BMS 182874 Hydrochloride

Quick Inquiry

Verification code

Featured Items