BML-284 - CAS 853220-52-7
Catalog number:
853220-52-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H18N4O3
Molecular Weight:
350.37
COA:
Inquire
Targets:
Wnt
Description:
BML-284 is potent selective, and cell-permeable Wnt signaling activator that does not inhibit GSK-3β (IC50 > 60 µM). It appears to mimic the effects of a Wnt ligand in a Xenopus model and may be a useful tool in the study of physiological processes that involve the Wnt pathway in vivio. It is effective in vivo, decreasing tissue damage and improving renal function after ischemia-reperfusion in rats. It induces in vitro β-catenin and transcription factor (TCF) dependent transcriptional activity in 293T cells in a dose dependent manner with an EC50 of 0.7 mM in vitro.
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Purity:
>98%
Appearance:
Solid powder
Synonyms:
Wnt Agonist;IN1013;2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine;4-N-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine;N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine
Solubility:
DMSO: ≥ 30 mg/mL
Storage:
2-8°C
MSDS:
Inquire
Application:
BML-284 may be a useful tool in the study of physiological processes that involve the Wnt pathway.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams-Kilos
Boiling Point:
623.4±65.0 °C | Condition: Press: 760 Torr
Density:
1.353±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
FABQUVYDAXWUQP-UHFFFAOYSA-N
InChI:
InChI=1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)
Canonical SMILES:
COC1=CC=CC(=C1)C2=CC(=NC(=N2)N)NCC3=CC4=C(C=C3)OCO4
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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