|Description||BML-284 is potent selective, and cell-permeable Wnt signaling activator that does not inhibit GSK-3β (IC50 > 60 µM). It appears to mimic the effects of a Wnt ligand in a Xenopus model and may be a useful tool in the study of physiological processes that involve the Wnt pathway in vivio. It is effective in vivo, decreasing tissue damage and improving renal function after ischemia-reperfusion in rats. It induces in vitro β-catenin and transcription factor (TCF) dependent transcriptional activity in 293T cells in a dose dependent manner with an EC50 of 0.7 mM in vitro.|
|B0084-474867||25 mg||$198||In stock|
|Synonyms||AMBMP HCl; AMBMP Hydrochloride; BML284 HCl; Wnt Agonist; BML284 HCl; BML-284 HCl; BML 284 HCl; Wnt Agonist;IN1013;2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine;4-N-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine;N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine|
|Solubility||DMSO: ≥ 30 mg/mL|
|Application||BML-284 may be a useful tool in the study of physiological processes that involve the Wnt pathway.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Boiling Point||623.4±65.0 °C | Condition: Press: 760 Torr|
|Density||1.353±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
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