BLU-554 - CAS 1707289-21-1
Catalog number: B0084-008122
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
BLU-554 is a potent and selective inhibitor of fibroblast growth factor receptor 4 (FGFR4) (IC50 = 5 nM), which is promisingly to be used for the treatment of hepatocellular carcinoma and cholangiocarcinoma.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-008122 10 mg $198 In stock
B0084-008122 100 mg $998 In stock
Bulk Inquiry
Brife Description:
A potent and selective inhibitor of fibroblast growth factor receptor 4 (FGFR4) (IC50 = 5 nM)
99.08 %
Solid Powder
BLU-554; BLU 554; BLU554, Fisogatinib; SCHEMBL16668287; EX-A841; MFCD30496704; N-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]oxan-4-yl]prop-2-enamide; BLU554
DMSO Solubility: 100 mg/mL warmed (198.65 mM)
Store in a cool and dry place (or refer to the Certificate of Analysis).
1.4±0.1 g/cm3
Canonical SMILES:
1.Update in Systemic and Targeted Therapies in Gastrointestinal Oncology.
Yee NS Biomedicines. 2018 Mar 16;6(1). pii: E34. doi: 10.3390/biomedicines6010034.
Progress has been made in the treatment of gastrointestinal cancers through advances in systemic therapies, surgical interventions, and radiation therapy. At the Multi-Disciplinary Patient Care in Gastrointestinal Oncology conference, the faculty members of the Penn State Health Milton S. Hershey Medical Center presented a variety of topics that focused on this sub-specialty. This conference paper highlights the new development in systemic treatment of various malignant diseases in the digestive system. Results of the recent clinical trials that investigated the clinical efficacy of pegylated hyaluronidase, napabucasin, and L-asparaginase in pancreatic carcinoma are presented. The use of peri-operative chemotherapy comprised of 5-fluorouracil or capecitabine, leucovorin, oxaliplatin, and docetaxel (FLOT), and immunotherapy including pembrolizumab, nivolumab, and ipilimumab in gastroesophageal carcinoma are discussed. Data from clinical trials that investigated the targeted therapeutics including nivolumab, ramucirumab, lenvatinib, and BLU-554 are reported. The role of adjuvant capecitabine in resected biliary tract carcinoma (BTC) and nab-paclitaxel in combination with gemcitabine and cisplatin in advanced BTC are presented.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related FGFR Products

CAS 1707289-21-1 BLU-554

(CAS: 1707289-21-1)

BLU-554 is a potent and selective inhibitor of fibroblast growth factor receptor 4 (FGFR4) (IC50 = 5 nM), which is promisingly to be used for the treatment of h...

E 3810 dihydrochloride

E 3810 dihydrochloride is a dual VEGFR/FGFR tyrosine kinase inhibitor. It suppresses the tumor angiogenesis and tumor cell proliferation via inhibiting VEGFR1, ...

CAS 656247-17-5 Nintedanib

(CAS: 656247-17-5)

Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59...

CAS 939805-30-8 ACTB-1003

(CAS: 939805-30-8)

ACTB-1003 is an oral kinase inhibitor with multiple modes of action, targeting cancer mutations via FGFR inhibition FGFR1, angiogenesis through inhibition of VE...

CAS 692737-80-7 Dovitinib lactate

Dovitinib lactate
(CAS: 692737-80-7)

Dovitinib, also referred as CHIR-258 or TKI258, is a potent receptor tyrosine kinase inhibitor (TKI) that selectively targets VEGFR, PDGFR, FGFR, CSF1R, c-KIT, ...

CAS 1346242-81-6 Erdafitinib

(CAS: 1346242-81-6)

Erdafitinib, also known as JNJ-42756493, is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential an...

CAS 326914-10-7 SU11652

(CAS: 326914-10-7)

SU11652 is a cell-permeable and sunitinib-like inhibitor of tyrosine kinase receptor (RTK) and angiogenesis with antineoplastic property. It selectively inhibit...

Fibroblast Growth Factor-Basic
(CAS: 106096-93-9)

Fibroblast Growth Factor-Basic is a growth factor encoded by the FGF2 gene. It is found in basement membranes and sub-endothelial extracellular matrix. FGF2 spe...

Chemical Structure

CAS 1707289-21-1 BLU-554

Quick Inquiry

Verification code

Featured Items