{"id":547,"date":"2016-10-17T02:30:09","date_gmt":"2016-10-17T07:30:09","guid":{"rendered":"http:\/\/www.bocsci.com\/blog\/?p=547"},"modified":"2016-10-17T02:39:49","modified_gmt":"2016-10-17T07:39:49","slug":"547","status":"publish","type":"post","link":"https:\/\/www.bocsci.com\/blog\/547\/","title":{"rendered":"Ursodeoxycholic acid"},"content":{"rendered":"

Bile acids (BAs) are natural detergents that solubilize dietary\u00a0lipids in the intestinal tract. They are also important signaling\u00a0molecules. BA regulate not only their own synthesis, but also have a\u00a0role in metabolic syndrome, obesity<\/a>, and diabetes<\/a>. High concentrations of hydrophobic BA such as deoxycholic acid<\/a>\u00a0produce\u00a0deleterious effects in liver disorders. Among the different mechanisms triggered by them, there is evidence that they induce cell\u00a0death via apoptosis. Sodium deoxycholate (NaDOC) activates cell\u00a0death receptor independently of ligands, stimulates p53, EF2-1\u00a0and Cyclin D1 expression, and induces oxidative damage,\u00a0mitochondrial swelling and glutathione (GSH) depletion. Any of\u00a0these alterations are enough to activate caspases leading to cell\u00a0death by apoptosis. More hydrophilic BAs such as ursodeoxycholic\u00a0acid<\/a> (UDCA) prevents the reactive oxygen species formation,\u00a0mitochondrial dysfunction and death receptor induced apoptosis,\u00a0blocking the apoptosis. The anti-apoptotic effects of UDCA were\u00a0initially observed in hepatocytes, not only due to an inhibition of\u00a0ROS production but also by avoiding the release of pro-apoptotic\u00a0factors from the mitochondria. Due to the protective properties against cytotoxic BAs, UDCA has been used as a first choice\u00a0treatment for a number of cholestatic liver diseases, mainly primary biliary cirrhosis.<\/p>\n

As we know, liver cancer is the second most common cause of cancer death\u00a0worldwide. Several studies illustrate that constitutive nuclear factor-\u03baB (NF-\u03baB)\u00a0activity plays a central role in the hepatic neoplastic progression\u00a0through the upregulation of anti-apoptotic genes. Moreover, the inhibition of NF-\u03baB activation in hepatocytes\u00a0retards and reduces the development of hepatocellular carcinoma in\u00a0mice. Therefore, the inhibition of NF-\u03baB activation might be an effective strategy to treat liver cancers.<\/p>\n

Glycyrrhizin<\/a>, the triterpenoid saponin from Glycyrrhiza glabra\u00a0L. roots (licorice), consists of one molecule of glycyrrhetinic acid\u00a0and two molecules of glucuronic acid. Glycyrrhizin exhibits various\u00a0pharmacological effects, such as anti-inflammatory and protective\u00a0effects in liver. Therefore, glycyrrhizin analogs, such\u00a0as magnesium isoglycyrrhizinate and stronger neo-minophagen C,\u00a0are effective and safe for the treatment of patients with chronic liver\u00a0disease and liver dysfunction.<\/p>\n

Silymarin<\/a>\u00a0is a flavonolignan complex from Silybum marianum <\/i><\/em>(L.)\u00a0Gaertn. fruits. Silymarin comprises a number of flavonolignans, including silibinin (silybin A and silybin B), isosilybin A and B, silychristin A and B, silydianin, and other phenolic compounds. Silymarin exhibits anti-inflammatory and immunomodulatory effects and thus promotes the health of livers. In addition, silymarin-type drugs like legalon have been used\u00a0for the treatment of acute hepatitis and nonalcoholic fatty liver disease in patients.<\/p>\n

\"65666-07-1\"<\/a><\/p>\n

Silymarin – CAS 65666-07-1<\/a><\/h4>\n

Ursodeoxycholic acid, a hydrophilic stereoisomer of chenodeoxycholic acid, is a major component of Chinese black bear\u2019s bile. Ursodeoxycholic acid is used to treat chronic cholestatic\u00a0liver diseases, such as primary biliary cirrhosis and primary sclerosing cholangitis. Moreover, some\u00a0evidences indicate that ursodeoxycholic acid decreases the levels of\u00a0alanine aminotransferase, aspartate aminotransferase, and gammaglutamyl transpeptidase in patients with chronic hepatitis C and protects livers from against methotrexate-induced toxicity.<\/p>\n

\"128-13-2\"<\/a><\/p>\n

Ursodeoxycholic acid CAS 128-13-2<\/a><\/h4>\n

In addition to this, ursodeoxycholic acid is a tertiary bile acid in humans, and\u00a0large doses have been used as a hepatoprotective drug in the\u00a0treatment of antivirus therapy non-responsive chronic hepatitis C and primary biliary cirrhosis. Although the detailed mechanism of its hepatoprotective\u00a0effect remains to be clarified, it may be due to its antioxidative effect\u00a0and protection against apoptosis caused by mitochondria injury.<\/p>\n

Related Products:<\/h4>\n
<\/div>
<\/th><\/th><\/th><\/th><\/th><\/tr><\/thead>
CAS Number <\/td>Product Name <\/td>Molecular Formula <\/td>Molecular Weight <\/td>Description <\/td><\/tr>
128-13-2 <\/td>Ursodeoxycholic acid<\/a><\/td>C24H40O4 <\/td>392.57 <\/td>Ursodeoxycholic acid (UDCA) is a cell protectant used extensively to mitigate hepatic and biliary diseases. Ursodeoxycholic acid may be used to study its specific activities that range from reduction of cholesterol absorpition, cholesterol gallstone dissolution to suppression of immune response. <\/td><\/tr>
1405-86-3 <\/td>Glycyrrhizin<\/a><\/td>C42H62O16 <\/td>822.93 <\/td>Glycyrrhizin (Glycyrrhizic Acid) is a widely used anti-inflammatory agent isolated from the licorice root. <\/td><\/tr>
65666-07-1 <\/td>Silymarin<\/a><\/td>C25H22O10 <\/td>482.44 <\/td>Silymarin is a unique flavonoid complex\u2014containing silybin, silydianin, and silychrisin\u2014that is derived from the milk thistle plant. <\/td><\/tr>
83-44-3 <\/td>Deoxycholic Acid<\/a><\/td>C24H40O4 <\/td>392.58 <\/td>Deoxycholic acid, also known as deoxycholate, cholanoic acid, and 3\u03b1,12\u03b1-dihydroxy-5\u03b2-cholanate, is a bile acid. Deoxycholic acid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. Deoxycholic acid is soluble in alcohol and acetic acid. When pure, it comes in a white to off-white crystalline powder form. <\/td><\/tr><\/tbody><\/table><\/div>\n","protected":false},"excerpt":{"rendered":"

Bile acids (BAs) are natural detergents that solubilize dietary\u00a0lipids in the intestinal tract. They are also important signaling\u00a0molecules. BA regulate not only their own synthesis, but also have a\u00a0role in […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[181],"tags":[329,330,311,331],"_links":{"self":[{"href":"https:\/\/www.bocsci.com\/blog\/wp-json\/wp\/v2\/posts\/547"}],"collection":[{"href":"https:\/\/www.bocsci.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bocsci.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bocsci.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bocsci.com\/blog\/wp-json\/wp\/v2\/comments?post=547"}],"version-history":[{"count":5,"href":"https:\/\/www.bocsci.com\/blog\/wp-json\/wp\/v2\/posts\/547\/revisions"}],"predecessor-version":[{"id":555,"href":"https:\/\/www.bocsci.com\/blog\/wp-json\/wp\/v2\/posts\/547\/revisions\/555"}],"wp:attachment":[{"href":"https:\/\/www.bocsci.com\/blog\/wp-json\/wp\/v2\/media?parent=547"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bocsci.com\/blog\/wp-json\/wp\/v2\/categories?post=547"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bocsci.com\/blog\/wp-json\/wp\/v2\/tags?post=547"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}