Recent achievements in the field of hypertension research

  1. Long-term hypertension in Hypertension: may damage the vascular health of the brain.


Recently, in a study published in the international journal Hypertension, scientists from the University of Michigan School of Medicine and other institutions found that long-term hypertension may increase the risk of damage to small and medium-sized blood vessels in the brain, which is often directly related to the risk of dementia and stroke. We have long known that high blood pressure can lead to stroke, but past studies have only linked high blood pressure to the risk of Alzheimer’s disease. In this new study, the researchers focused on how high blood pressure affects the brain’s small blood vessel disease, the most frequent cerebrovascular disease in patients with stroke and dementia.

In the article, the researchers studied 1686 adults who did not suffer from stroke or dementia at the beginning of the study and analyzed the data of the participants. the researchers measured their blood pressure in the middle and old age of the participants, and performed brain MRIs scans to check for microhemorrhage in different parts of the brain, accumulation of small and medium-sized blood products in brain tissue, and brain tissue death. These problems are all signs of small blood vessel disease in the brain.

  1. BMJ: Drinking milk can reduce the risk of diabetes and hypertension.


In the United States, the incidence of high blood pressure and diabetes is on the rise. A large international study recently found a link between eating more dairy products (especially whole dairy products) and lower blood pressure and lower incidence of diabetes.

The volunteers involved in the study included nearly 150000 people from 21 countries, including Africa, Asia, Europe, and North and South America. Participants ranged in age from 35 to 70. In the study, published in the journal BMJ Open Diabetes Research & Care, the researchers used questionnaires to learn about participants’ food intake throughout the year. Participants in the survey outlined the amount of certain types of food they ate, including milk, yogurt, cheese and milk products such as foods made from milk. In addition, dairy products are further classified as full-fat or low-fat. The researchers also considered the participants’ medical history, prescription, blood pressure, waistline, glucose and fat levels, as well as education, which is important for the diagnosis of type 2 diabetes.

  1. EHJ NEJM: Hypertension may be closely related to the increased risk of death from COVID-19 infection.

Doi:10.1093/eurheartj/ehaa433 doi:10.1056/NEJMoa2006923.

A few days ago, in a study published in the international journal European Heart Journal, scientists from Xijing Hospital and other institutions found that hypertensive patients are twice as likely to die from COVID-19 infection compared with patients without hypertension, and hypertensive patients who do not take medication to control their blood pressure may have a higher risk of dying from COVID-19 infection.

In the article, the researchers analyzed the data of 2866 patients admitted to Huoshenshan Hospital in Wuhan from February 5 to March 15, 2020. Among them, 850 (29.5%) had a history of hypertension. Researcher Professor Li Fei said that 34 (4%) of the 850 hypertensive patients died of COVID-19 infection, while 22 (1.1%) of 2027 non-hypertensive patients died of COVID-19 infection. After adjusting for factors such as age, gender and other medical conditions, the researchers found that hypertensive patients were 2.12 times more likely to die from COVID-19 than non-hypertensive patients.

  1. Neurology: Night Hypertension is easy to affect brain Health?


Most people’s blood pressure drops at night, which doctors call “hypotension”. But for people with high blood pressure, their nocturnal blood pressure will remain the same, or even rise. People with high blood pressure and nocturnal blood pressure may be more likely to develop vascular disease and memory problems associated with damage to areas of the brain, according to a new study published in the journal Neurology.

The researchers say the results provide more evidence of the importance of vascular risk factors in promoting memory problems through efforts, such as maintaining a healthy weight, physical activity and a healthy diet, can effectively prevent the potential effects of high blood pressure. ” The study involved 435 people with an average age of 59 who participated in an aging study in Venezuela. Their blood pressure was monitored at home for 24 hours with a device, measured every 15 minutes during the day and every 30 minutes at night. At the same time, they also performed brain scans to look for areas of the brain associated with damage to white matter hyperplasia. The participants also tested memory and other thinking abilities.

  1. Circulation: Low-fiber diet leads to hypertension.


Recently, a study by scientists at Monash University confirmed for the first time that a low-fiber diet may lead to high blood pressure. If left untreated, high blood pressure can lead to strokes, myocardial infarction, stiffness of heart arteries and muscles, and stiff kidneys, which can reduce its function. Hypertension is also the most common risk factor for cardiovascular disease. In the study, published in the journal Circulation, the authors used a mouse model to test the difference between a high-resistant starch diet and a low-resistant starch diet. Resistant starch is a kind of fiber food that can resist gastrointestinal digestion until it is absorbed by probiotics when it reaches the large intestine.

It was found that mice fed a low-fiber diet were more likely to develop high blood pressure. After that, through the experiment of aseptic mouse fecal transplantation, the researchers showed that the change of intestinal microbial ecology caused by low-fiber diet was the direct cause of hypertension. High blood pressure remains a major risk factor for cardiovascular death, the researchers said. A fiber-deficient diet is associated with the prevalence of high blood pressure, but this study reveals the role of intestinal flora in it.

  1. Experi Physiol: Scientists are expected to develop new treatments for hypertension.


In a study published in the international journal Experimental Physiology, scientists from Boston University School of Medicine found that the key to treating high blood pressure may lie in people who can resist high blood pressure even if they eat high-salt foods. In the UK, 1/4 adults are affected by hypertension. At present, there are more than 1.1 billion people with hypertension in the world. Hypertension is one of the biggest unsolved global public health problems so far. At the same time, hypertension is also the main cause of a variety of diseases, including chronic kidney disease, stroke and heart disease.

Some people’s blood pressure will soar after eating a high-salt diet, while others will tolerate salt, and there will be no change in blood pressure even after a high-salt diet. one way to combat the blood pressure problem is to simulate how these tolerant (high-salt diet tolerance) people avoid high blood pressure. In the article, the researchers revealed how cells in specific areas of the hypothalamus control the mechanism of salt tolerance, and they found a special class of structural changes in these cells that may help alter the body’s response to salt.

  1. Cardiovasc Res: Gingival disease is associated with a higher risk of hypertension.


According to a recent study published in the journal Cardiovascular Research, people with gum disease (periodontitis) are more likely to develop high blood pressure (hypertension). Professor Francesco D’Aiuto, senior author of the study and professor of the Eastman Institute of Dental Studies at the University of London, said: “We found that the more severe periodontitis, the higher the risk of high blood pressure.” the results suggest that people with gum disease should be aware of their risk and make recommendations on lifestyle changes to prevent high blood pressure, such as exercise and a healthy diet.

High blood pressure affects 30-45% of adults and is the leading cause of premature death worldwide, while periodontitis affects more than 50% of the world’s population. Hypertension is a major preventable cause of cardiovascular disease, and periodontitis is associated with an increased risk of heart attack and stroke. “Hypertension may be a cause of heart attack and stroke in patients with periodontitis. Previous studies have shown a link between periodontitis and hypertension, and dental treatment may improve blood pressure, but so far, the results are inconclusive.

  1. Eur Heart J Suppl: About 50% of people may not realize that they have high blood pressure.


In a recent study published in the international journal European Heart Journal Supplements, scientists from institutions such as the University of Western Australia found that 50 percent of patients with high blood pressure in Australia may not be aware of their illness. High blood pressure is the leading cause of death from cardiovascular disease in the world, and it also affects the health of about 6 million Australian adults.

In the study, the researchers studied 3817 adults, of whom 31.2% had high blood pressure, only about half of them knew about their condition, and 40% of the individuals who received treatment still had blood pressure higher than the standard value. Individuals who smoke, drink alcohol or have cerebrovascular diseases are at greater risk of elevated blood pressure. Although there are many effective treatments for high blood pressure, only half of the affected individuals can be treated, and only 60 percent of the people who receive treatment can control their blood pressure, researcher Markus Schlaich said.

  1. Low dose Hypertension: radiation increases the risk of hypertension.


Long-term exposure to low doses of ionizing radiation increases the risk of high blood pressure, according to a study of Russian nuclear power plant workers published in the Hypertension Journal of the American Heart Association. Uncontrolled high blood pressure can lead to heart attacks, strokes, heart failure and other serious health problems.

Earlier studies have linked high-dose radiation exposure to cardiovascular disease and an increased risk of death from these diseases. The study found for the first time that the risk of high doses of ionizing radiation increased among a large number of workers who had been exposed for years. The study included more than 22000 workers at Mayak Production Association, Russia’s first large nuclear power company. These workers were employed between 1948 and 1982 for an average of 18 years. Half of them have worked there for more than ten years. All workers have a comprehensive health check and screening test at least once a year and a high-level assessment every five years.

  1. eLife: Scientists are expected to develop a new targeted drug therapy for hypertension.


In a recent study published in the international journal eLife, scientists from the Health Science Research Center of the University of Tennessee identified a key molecule in blood pressure regulation that can effectively lower blood pressure in mice by turning off the molecule’s function.

The study ends scientists’ uncertainty about the effects of the molecule on high blood pressure, which now affects the health of millions of people around the world, and is expected to help develop new drugs for high blood pressure. it is also a major risk factor for heart attacks and strokes. Blood pressure is partially controlled by muscle cells in the body’s blood vessel wall, which carry special proteins called transient receptor potential channels (TRP channels), which promote the movement of sodium and calcium; there are about 13 different TRP channels in arterial muscle cells, and it is not clear whether these channels control normal blood pressure or help promote high blood pressure.


1. Chesebro, A. G., Melgarejo, J. D., Leendertz, R., Igwe, K. C., Lao, P. J., Laing, K. K., … & Lee, J. H. (2020). White matter hyperintensities mediate the association of nocturnal blood pressure with cognition. Neurology94(17), e1803-e1810.

2. Azizova, T., Briks, K., Bannikova, M., & Grigoryeva, E. (2019). Hypertension incidence risk in a cohort of Russian workers exposed to radiation at the Mayak production association over prolonged periods. Hypertension73(6), 1174-1184.

3. Van Minh, H., Viet, N. L., Sinh, C. T., Hung, P. N., Mong Ngoc, N. T., Hung, N. V., … & Tuan, H. C. (2019). Blood pressure screening during the May Measurement Month 2017 programme in Vietnam—South-East Asia and Australasia. European Heart Journal Supplements21(Supplement_D), D127-D129.

4. Muñoz Aguilera, E., Suvan, J., Buti, J., Czesnikiewicz-Guzik, M., Barbosa Ribeiro, A., Orlandi, M., … & D’Aiuto, F. (2020). Periodontitis is associated with hypertension: a systematic review and meta-analysis. Cardiovascular research116(1), 28-39.

5. Petrea, R. E., O’Donnell, A., Beiser, A. S., Habes, M., Aparicio, H., DeCarli, C., … & Romero, J. R. (2020). Mid to Late Life Hypertension Trends and Cerebral Small Vessel Disease in the Framingham Heart Study. Hypertension, HYPERTENSIONAHA-120.