Research Hotspot

ADCs

Several Ways of Thiol Coupling in ADCs

The popularity of thiol coupling in ADC preparation can be attributed to three factors: It is essential to note that a reduction step is always required before coupling to release […]

Hypoglycemic Functional Factors in Natural Products and Their Mechanisms of Action

Hypoglycemic Functional Factors in Natural Products and Their Mechanisms of Action

Diabetes is a common clinical disease, and with the improvement of living standards, an increase in the number of obese people, and the intensification of aging populations, the incidence of […]

Research Progress on Adjuvants for Influenza Vaccines

Research Progress on Adjuvants for Influenza Vaccines

Influenza is an acute and highly contagious respiratory disease caused by influenza A and B viruses. Annual influenza epidemics are caused by several different seasonal influenza viruses (i.e., A/H1N1, A/H3N2, B/Yamagata, […]

ADC payloads

Antibody-Drug Conjugates: New Strategies of ADC Payloads

The concept of ADCs was first proposed by Nobel Prize winner Paul Ehrlich in 1913. But it was not until 1975, when hybridoma technology began to be used to produce monoclonal […]

mRNA Vaccines

Immunogenicity Analysis of mRNA Vaccines

The Background of mRNA Vaccines At the beginning of 2020, the COVID-19 outbreak occurred. To establish a protective barrier against the pandemic, it was essential to rapidly develop safe and effective vaccines. mRNA vaccines […]

ADC drugs

Quantitative Bioanalysis of Antibody-Drug Conjugates (ADCs)

Antibody-Drug Conjugates (ADCs) are new therapies that combine the high targeting of monoclonal antibodies with the strong cytotoxicity of small molecule cytotoxins. Due to its precise and powerful mechanism of action, […]

blood brain barrier

Peptides Crossing the Blood-Brain Barrier

It is well-known that most peptide molecules cannot cross the blood-brain barrier (BBB). This is because the BBB is a highly selective biological barrier composed of specialized types of endothelial cells that form a […]

Research Progress of Dual-Loading ADCs

Antibody-drug conjugate (ADC) combines the tumor targeting specificity of monoclonal antibodies and the potent cell killing activity of cytotoxic drugs (warhead/payload), through a carefully designed chemical linker (linker). The two are […]

Trastuzumab ADC

Review of Structure-Activity Relationship Based on Trastuzumab ADC

Many approaches have been developed to improve the physical/chemical properties, potency and selectivity of antibody-drug conjugates (ADCs). Trastuzumab (Tz), a monoclonal antibody targeting HER2, was approved by the FDA in […]

Glycoconjugate Vaccine

Composition and Immune Mechanism of Glycoconjugate Vaccine

A conjugate vaccine is a type of vaccine that combines a weak or non-toxic part of a disease-causing microorganism (such as a bacteria or virus) with a carrier protein. The […]