Drug Discovery

mRNA delivery

mRNA Strategies for Cancer Immunotherapy

Cancer immunotherapy holds enormous potential in combating malignant tumors. Messenger ribonucleic acid (mRNA) has emerged as a widely studied tool in recent years, functioning within the cytoplasm and eliminating the […]

siRNA Drug Delivery

siRNA Drug Delivery Across the Blood-brain Barrier in Alzheimer’s Disease

Alzheimer’s disease (AD) is a very common neurodegenerative disease in old age, which not only affects the patient’s thinking, memory and independence, but also leads to a decline in the quality of […]

drug discovery

Prodrug Activation Strategies in Drug Discovery

A prodrug, also known as a precursor drug, generally refers to a class of compounds that are themselves inactive or have weak activity but, after conversion within a biological organism, […]

Differences Between Protein Degraders and Traditional Small Molecule Drugs

Targeted protein degradation (TPD) is an emerging protein degradation technology in recent decades that utilizes the cell’s own protein clearance mechanisms, such as lysosomal degradation and proteasomal degradation, to degrade target […]

delivery system

Advances in Non-Viral Vector Delivery Systems for Nucleic Acid Drugs

Nucleic acid drugs are mainly divided into two major categories: small nucleic acid drugs and mRNA. Small nucleic acid drugs, also known as oligonucleotide drugs, include antisense nucleotides (ASO), small […]

ADC payloads

History of ADC Payloads and Its Pharmacokinetic Profiles

Chemotherapy drugs are an important means of tumor treatment. At present, chemotherapy drugs based on different mechanisms have been developed, which can act on the initial raw materials such as […]

ADC toxicity

Effects of ADC Toxicity and Optimization Strategies

So far, the FDA and EMA have approved six ADC drugs for patients with solid tumors. Fig. 1 depicts the composition of each ADC (targeting antigen, mAb type, payload, and linker), […]

inhibitors

Peptide Covalent Inhibitors Targeting Protein-Protein Interactions

Covalent drugs refer to those drug molecules that form strong bonds with receptors through the formation of covalent bonds. It all began with aspirin in 1899, gained prominence with ibrutinib in […]

deuterated drugs

Deuterated Drugs Research Progress

What are Deuterated Drugs? Deuterated drugs are medications obtained by substituting hydrogen atoms at specific positions on drug molecules with deuterium atoms. The most widely used application involves replacing carbon-hydrogen (C-H) bonds with […]

Cyclic Peptide Inhibitors of KRAS

Challenges and Advantages in the Development of Cyclic Peptide Inhibitors of KRAS

Over the past several decades, direct inhibition of the RAS family of oncogenic proteins has been a significant challenge in the field of drug development. Despite accounting for approximately 30% […]