Breast cancer is the leading cause of death among women worldwide. When breast cancer spreads to other parts of the body, the prognosis is poor. Currently, there is no treatment […]
Introduction of Oligonucleotides Oligonucleotide-based therapeutics represent a rapidly advancing field in current drug development. According to their therapeutic mechanisms, oligonucleotide drugs can be categorized into antisense oligonucleotides (ASOs), small interfering RNA (siRNA), […]
During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis […]
Antimicrobial peptides (AMPs) are naturally occurring peptide molecules found in various organisms, including humans, animals, plants, and microorganisms. These peptides play a crucial role in the innate immune system’s defense against microbial […]
Glycosylation is a complex form of post-translational modification that affects more than 50% of cellular proteins and is a key regulator of many eukaryotic processes. Aberrant glycosylation is a common […]
The Background of mRNA Vaccines At the beginning of 2020, the COVID-19 outbreak occurred. To establish a protective barrier against the pandemic, it was essential to rapidly develop safe and effective vaccines. mRNA vaccines […]
It is well-known that most peptide molecules cannot cross the blood-brain barrier (BBB). This is because the BBB is a highly selective biological barrier composed of specialized types of endothelial cells that form a […]
As an important drug modality, the development of oligonucleotides will continue to expand in the coming years. Oligonucleotide drugs are a class of therapeutic agents composed of short nucleotide sequences […]
Compared with viral vectors, non-viral delivery vectors are easier to scale up and have the ability to solve the most critical safety issues. Thanks to the LNP-mRNA vaccine that came […]
In recent years, PROteolysis TArgeting Chimeras (PROTAC), which utilizes the cell’s own degradation mechanisms to eliminate specific disease-related proteins, has emerged as one of the most promising methods. Apart from […]