Drug Discovery

ADC Target

ADC Therapeutic Targets in Breast Cancer

Breast cancer is the leading cause of death among women worldwide. When breast cancer spreads to other parts of the body, the prognosis is poor. Currently, there is no treatment […]

oligonucleotide drugs

Hybridization-ELISA in the Bioassay of Oligonucleotide Drugs

Introduction of Oligonucleotides Oligonucleotide-based therapeutics represent a rapidly advancing field in current drug development. According to their therapeutic mechanisms, oligonucleotide drugs can be categorized into antisense oligonucleotides (ASOs), small interfering RNA (siRNA), […]

lipid nanoparticles

Development of mRNA-Directed Delivery – LNP Delivery System

During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis […]

Antimicrobial Peptides

Mechanisms to Combat Drug Resistance: Overview of Antimicrobial Peptides

Antimicrobial peptides (AMPs) are naturally occurring peptide molecules found in various organisms, including humans, animals, plants, and microorganisms. These peptides play a crucial role in the innate immune system’s defense against microbial […]

Tumor Glycan

Targeting Tumor Glycans for Drug Development

Glycosylation is a complex form of post-translational modification that affects more than 50% of cellular proteins and is a key regulator of many eukaryotic processes. Aberrant glycosylation is a common […]

mRNA Vaccines

Immunogenicity Analysis of mRNA Vaccines

The Background of mRNA Vaccines At the beginning of 2020, the COVID-19 outbreak occurred. To establish a protective barrier against the pandemic, it was essential to rapidly develop safe and effective vaccines. mRNA vaccines […]

blood brain barrier

Peptides Crossing the Blood-Brain Barrier

It is well-known that most peptide molecules cannot cross the blood-brain barrier (BBB). This is because the BBB is a highly selective biological barrier composed of specialized types of endothelial cells that form a […]

Oligonucleotide Drug Development

Current Status and Prospects of Oligonucleotide Drug Development

As an important drug modality, the development of oligonucleotides will continue to expand in the coming years. Oligonucleotide drugs are a class of therapeutic agents composed of short nucleotide sequences […]

Lipid Nanoparticle

Lipid Nanoparticles (LNPs) Design and Formulation Production

Compared with viral vectors, non-viral delivery vectors are easier to scale up and have the ability to solve the most critical safety issues. Thanks to the LNP-mRNA vaccine that came […]

protac

Based on Antibody Targeted Protein Degradation

In recent years, PROteolysis TArgeting Chimeras (PROTAC), which utilizes the cell’s own degradation mechanisms to eliminate specific disease-related proteins, has emerged as one of the most promising methods. Apart from […]