Drug Discovery

The Latest Developments in ADC Payloads

The Latest Developments in ADC Payloads

Driven by increasingly mature technologies, ADC payloads have undergone three generations of innovation. In the first generation of ADC drugs, traditional chemotherapy agents such as methotrexate, vincristine, and doxorubicin were used […]

Comparison and Analysis of SMDC, ADC, and DAC

Comparison and Analysis of SMDC, ADC, and DAC

In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the […]

What is Peptide Nucleic Acid (PNA)?

What is Peptide Nucleic Acid (PNA)?

Peptide Nucleic Acid (PNA) is a synthetic polymer similar to DNA or RNA. PNA can be said to have been born in Denmark, where it was originally developed by Peter E. […]

General Design Methods for mRNA Drugs

General Design Methods for mRNA Drugs

With the rapid development of biotechnology and molecular medicine, the introduction of mRNA as a vaccine or therapeutic agent enables the production of almost any desired functional protein/peptide within the […]

Clinical Prospects of Aptamer Applications

Clinical Prospects of Aptamer Applications

Aptamers are short RNA/DNA oligonucleotide molecules that bind specifically to complementary target molecules. As potential recognition elements, aptamers show promising applications in both diagnosis and treatment. They offer diverse therapeutic and diagnostic […]

CD137/4-1BB combination therapy

Two Paths of Second-Generation 4-1BB Agonists

CD137/4-1BB combination therapy

Mechanism of Action of Paclitaxel

Mechanism of Action of Paclitaxel

Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and neck cancers, […]

Covalent, Non-covalent, and Covalent Reversible Drug Design in Medicinal Chemistry

Covalent, Non-covalent, and Covalent Reversible Drug Design in Medicinal Chemistry

Chemical drugs can be classified into three categories based on their binding modes: covalent drugs, non-covalent drugs, and covalent reversible drugs. Covalent drugs have strong binding ability and high efficacy, […]

Research Progress on Adjuvants for Influenza Vaccines

Research Progress on Adjuvants for Influenza Vaccines

Influenza is an acute and highly contagious respiratory disease caused by influenza A and B viruses. Annual influenza epidemics are caused by several different seasonal influenza viruses (i.e., A/H1N1, A/H3N2, B/Yamagata, […]

Review of Popular Targets

Review of Popular Targets

In recent years, antibody therapies (including traditional antibodies and nano-antibodies) have become an important means of treating a wide range of human malignant diseases, and more than 100 antibody therapies […]