Custom Synthesis

What is Peptide Nucleic Acid (PNA)?

What is Peptide Nucleic Acid (PNA)?

Peptide Nucleic Acid (PNA) is a synthetic polymer similar to DNA or RNA. PNA can be said to have been born in Denmark, where it was originally developed by Peter E. […]

Mechanism of Action of Paclitaxel

Mechanism of Action of Paclitaxel

Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and neck cancers, […]

Covalent, Non-covalent, and Covalent Reversible Drug Design in Medicinal Chemistry

Covalent, Non-covalent, and Covalent Reversible Drug Design in Medicinal Chemistry

Chemical drugs can be classified into three categories based on their binding modes: covalent drugs, non-covalent drugs, and covalent reversible drugs. Covalent drugs have strong binding ability and high efficacy, […]

microbial production

Microbial Production of Bio-based Plastics

At the 5th United Nations Environment Assembly (UNEA-5) held in March 2022, 175 countries signed a resolution to end plastic pollution. The aim is to achieve a legally binding international agreement […]

terpenoid biosynthesis

Exploration of Terpenoid Biosynthesis in Filamentous Fungi

Using synthetic biology methods allows for the more efficient production of highly complex drug molecules compared to traditional chemical methods, with increased stability and controllability. Many drug components are currently […]

ADC payloads

Antibody-Drug Conjugates: Recent Overview of ADC Payloads

Among the first-generation ADC drugs, traditional chemotherapy drugs such as methotrexate, vinblastine, and doxorubicin were used as cytotoxic payloads. However, due to insufficient cytotoxicity and selectivity against tumor cells, the first-generation […]

ADC payloads

Antibody-Drug Conjugates: New Strategies of ADC Payloads

The concept of ADCs was first proposed by Nobel Prize winner Paul Ehrlich in 1913. But it was not until 1975, when hybridoma technology began to be used to produce monoclonal […]

protac design

PROTACs Design Strategy: CRBN Ligand Modification

PROTACs, a novel therapeutic approach, have garnered interest from numerous pharmaceutical companies, including Merck, Genentech, Pfizer, Novartis, Arvinas, C4 Therapeutics, Haisco Pharmaceutical, Kintor Pharmaceutical, and BeiGene. Currently, approximately 20 PROTACs […]

ADC drugs

Quantitative Bioanalysis of Antibody-Drug Conjugates (ADCs)

Antibody-Drug Conjugates (ADCs) are new therapies that combine the high targeting of monoclonal antibodies with the strong cytotoxicity of small molecule cytotoxins. Due to its precise and powerful mechanism of action, […]

peg lipid

PEG-Lipid: Structure and Properties

PEG-Lipid derivatives have the advantages of increasing the stability of liposomes, extending the half-life of blood circulation, improving tumor targeting efficiency and enhancing drug efficacy. In-depth study of the effects of […]