Cancer Treatment Development

Antimicrobial Peptides

Mechanisms to Combat Drug Resistance: Overview of Antimicrobial Peptides

Antimicrobial peptides (AMPs) are naturally occurring peptide molecules found in various organisms, including humans, animals, plants, and microorganisms. These peptides play a crucial role in the innate immune system’s defense against microbial […]

siRNA Design

Optimization of siRNA Design

The length of siRNA is 7-8 nm, the diameter is 2-3 nm, the molecular weight is 13-14 kDa, and it is hydrophilic. Therefore, unmodified and naked siRNA cannot passively cross […]

ADC targets

Nectin-4: A New Target of ADC

Overview of Nectin Nectin, a cell adhesion molecule belonging to the Immunoglobulin (Ig) superfamily, is a homologue of poliovirus receptor (PVR/CD155). It also known as poliovirus receptor-associated protein Receptor Related Protein (PVRL). […]

ADCs Make Their Mark in HER-Positive Cancers

ADCs Make Their Mark in HER-Positive Cancers

Members of the human epidermal growth factor receptor (HER) family, including HER1 (EGFR), HER2, HER3, and HER4, play central roles in regulating cell proliferation, survival, differentiation, and migration. Overexpression of […]

drug R&D

Small Molecule Targeted Cancer Immunotherapy Draws the New Roadmap for Cancer Treatment

As an alternative to surgery, radiotherapy, and chemotherapy, tumor therapy via the immune pathway has made significant advances in recent years. Among the targeted drugs of immuno-oncology (IO), Ab drugs […]

drug development

Make the Future of Integrin Targeted Cancer Therapeutics Brighter

Integrins are cell adhesion and signaling proteins that play important roles in a wide range of biological functions. Currently, integrin-targeting drugs have been extensively developed in areas including cardiovascular disease, […]

PARP1 structure and function

Beyond PARP1 Single-Target Inhibitors–Combined Therapy Reveals More Possibilities

In late 2014, the PARP inhibitor Olaparib was approved to treat ovarian cancer with BRCA mutations. Since then, research in the field of PARP has received extensive attention, especially in […]

Small Molecule Drugs for Cancer Immunotherapy

Progress and Promise: Small Molecule Drugs for Cancer Immunotherapy

Overview of cancer immunotherapy The most widely studied cancer immunotherapies are PD-1/PD-L1 immune checkpoint inhibitors and chimeric antigen receptor-T cell (CAR-T) therapy. With the expanded clinical applications, some defects of […]

Cancer

Immune Checkpoint Target: TIGIT

TIGIT is considered to be one of the most promising and potential targets, and a variety of evidence supports that TIGIT plays a key role in limiting the adaptive and […]

SARS

Mesothelin: A New Target for Cancer Therapy

Structure and function of mesothelin The MSLN gene is located in chromosome 16p13. It contains 17 exons, with a cDNA length of about 2138bp, has a 1884-bp open reading frame, […]