2017 March

Solid phase syntheses of S, N-substituted 2-mercaptobenzoimidazoles

Solid phase syntheses of S, N-substituted 2-mercaptobenzoimidazoles

2-Mercaptobenzoimidazoles are an interesting class of heterocycles in medicinal chemistry as their core structure is part of different established therapeutics. The most prominent ones of these drugs are omeprazole, which acts as a […]

Pharmacologic Options for the Treatment of Sarcopenia

Pharmacologic Options for the Treatment of Sarcopenia

Sarcopenia was originally defined as the age-related loss of muscle mass. Subsequently, it became obvious to clinicians that it was muscle quality, rather than muscle mass that determined the function of muscle. This […]

Androgen Receptor

Androgen Receptor

Nuclear Hormone Receptors Nuclear hormone receptors are a super-family of evolutionarily conserved ligandregulated transcription factors that collectively direct genomic programs for a wide array of biological processes including reproduction, development, metabolism, circadian […]

Mechanism of reaction of adenosine deaminase

A detailed mechanism of reaction has been proposed based on crystallography and site-directed mutagenesis data obtained for murine adenosine deaminase. The kinetic studies based on solvent isotope effects and measurements with halogen substituents […]