γ-Secretase is a multi-subunit protein complex that is composed of at least four proteins-Presenilin (PS), Nicastrin (Net), Presenilin-enhancer 2 (Pen2) and Anteriorpharyx defective (Aph). These four subunits form an active γ-Secretase complex in the […]
In cells, it has been shown that Syk becomes active after binding to the phosphorylated ITAMs located on the BCR. Syk binds the two ITAM phosphotyrosines through its tandem SH2 domains. Hydrogen/deuterium exchange […]
The two branches of the immune system, innate and adaptive, work together within an intricate network in order to respond to infectious threats while not destroying healthy self-tissue. As previously discussed, the […]
The clinical symptoms and signs of Alzheimer’s disease (AD) result from abnormalities associated with neuronal dysfunction and cell death in specific brain regions which are important in memory and cognitive functions. Damaged circuits include […]