2016 August

Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) is a leading cause of death among cancer patients. The 5-year overall survival rate in patients with localized cancer is 55.2 %, and this decreases to 4.3 % […]

Recent Updates on the Development of Ganetespib as a Hsp90 Inhibitor

Recent Updates on the Development of Ganetespib as a Hsp90 Inhibitor

Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone which modulates cellular homeostasis and environmental stress responses by interacting with more than 200 proteins, also known as Hsp90 client proteins, […]

Immune Checkpoint Inhibitors in Older Adults

Immune Checkpoint Inhibitors in Older Adults

Cancer is primarily a disease of the older adult with more than 50 % of new cases occurring in adults older than 65 years. The care of older adults with cancer can […]

Immune checkpoint inhibitors: a new frontier in bladder cancer

Immune checkpoint inhibitors: a new frontier in bladder cancer

  Immunotherapy and immune checkpoint inhibition in particular present an exciting opportunity for the treatment of bladder cancer. Over the last 30 years, bladder cancer patients have seen few advances in the […]

Checkpoint inhibitors in immunotherapy of ovarian cancer

Checkpoint inhibitors in immunotherapy of ovarian cancer

Ovarian cancer is a cancerous growth arising from numerous parts, mainly the outer lining of the ovary called germinal epithelium. It is the fifth leading cause of cancer-related death among women, which causes […]

Immune checkpoint inhibitors: a patent review(2010-2015)

Immune checkpoint inhibitors: a patent review(2010-2015)

The ability of the immune system to detect and eliminate cancer was first proposed over 100 years ago. Since then, T cells reactive against tumor-associated antigens have been detected in […]

New Drugs for the Treatment of Myelofibrosis

New Drugs for the Treatment of Myelofibrosis

Myelofibrosis (MF) includes primary MF and MF that has arisen from an antecedent polycythemia vera (PV) or essential thrombocythemia (ET) (post-PV/ET MF). MF can affect patients in various ways, including progressive splenomegaly, cytopenias (particularly […]

Prevalence of legal and illegal stimulating agents in sports

Prevalence of legal and illegal stimulating agents in sports

The drive to compete and win is as old as humankind. Throughout history, athletes have sought foods and potions to enhance physical performance. Stimulants were one of the first groups of substances which […]