2016 July

Efficacy of Bimatoprost in Glaucoma and Ocular Hypertension Unresponsive to Latanoprost

Efficacy of Bimatoprost in Glaucoma and Ocular Hypertension Unresponsive to Latanoprost

As a member of the prostamide class of ocular hypotensives, bimatoprost (Lumigan®) lowers intraocular pressure (IOP) by a dual mechanism: by increasing both pressure-dependent (presumed trabecular meshwork) and pressure-independent (presumed […]

Inhibition of prostatic cancer growth by ginsenoside Rh2

Inhibition of prostatic cancer growth by ginsenoside Rh2

Prostate cancer develops in the prostate, which is a gland in the male reproductive system. Prostate cancers generally grow slowly. However, aggressive prostate cancers do occur, which are capable of […]

Anticholinergic Treatment in Airways Diseases

Anticholinergic Treatment in Airways Diseases

Acute and chronic airways diseases represent a large proportion of the inpatient and outpatient population continuously under the care of pulmonary physicians and primary healthcare providers. This review article aims […]

Pharmacokinetic properties and metabolism of idebenone

Pharmacokinetic properties and metabolism of idebenone

Idebenone (2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone) is a synthetic analogue of ubiquinone, an essential constituent of the electron transport chain and a vital cell membrane anti-oxidant. It has been shown that patients with Friedreich […]

Photoprotective effects of nicotinamide

Photoprotective effects of nicotinamide

In Australia, the lifetime risk of developing non-melanoma skin cancer such as basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) is almost 70% for men and 60% for women. […]

EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2

EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2

Glioblastoma multiforme (GBM) is the most malignant primary human brain cancer and cannot be cured by any therapy available today. Current therapy includes complex treatments of neurosurgical resection, radiotherapy, and […]

The importance of impurity analysis in pharmaceutical products: an integrated approach

The importance of impurity analysis in pharmaceutical products: an integrated approach

Pharmaceutical industry is growing day by day with the aim to develop new drugs extracted from natural products or synthetic chemically produced drug substances, but one thing always remains constant, […]

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Pyrazinamide

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Pyrazinamide

A biowaiver monograph of pyrazinamide based on literature data together with some additional experimental data is presented. The risks of basing a bioequivalence (BE) assessment on in vitro rather than […]