2016 June

Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

The study of carbamazepine solid forms continues to be a forum for advancing fundamental knowledge about polymorphism, hydrate formation, crystal engineering of pharmaceuticals, and structure–property relationships of pharmaceutical relevance. The […]

Progress in The Development of New Drugs in Alzheimer’s Disease

Progress in The Development of New Drugs in Alzheimer’s Disease

Alzheimer’s disease (AD) is an age-related neurodegenerative disease that is characterized by a progressive loss of memory associated with other cognitive sphere deficits interfering with social and occupational functioning. The […]

Roquinimex inhibits dextran sodium sulfate-induced murine colitis

Roquinimex inhibits dextran sodium sulfate-induced murine colitis

The majority of inflammatory bowel disease (IBD) consists of two related but clinically and histologically distinct conditions, ulcerative colitis and Crohn’s disease. Both conditions are characterized by chronically relapsing inflammation […]

Self-assembled gellan-based nanohydrogels as a tool for prednisolone delivery

Self-assembled gellan-based nanohydrogels as a tool for prednisolone delivery

In recent years, significant efforts have been devoted to the development of amphiphilic polymers consisting of hydrophilic polysaccharides and hydrophobic moieties because of their ability to form nanoparticle self-assemblies in […]

Comparison of the Pharmacokinetics of Albendazole and its Major Metabolites after Oral Administration of Albendazole as a Suspension and as a Paste Formulation to Sheep

Comparison of the Pharmacokinetics of Albendazole and its Major Metabolites after Oral Administration of Albendazole as a Suspension and as a Paste Formulation to Sheep

Albendazole is a member of the benzimidazole group of anthelmintics with broad-spectrum activity against gastro-intestinal roundworms including inhibited larval stages, tapeworms, liver flukes and lungworms in many species. In the […]

Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists

Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists

The vertebrate orexin neuropeptide–receptor system plays a pivotal role in the regulation of sleep and wake states as well as emotional states related to stress or reward. The neuropeptides orexin […]

Small-molecule modulators of the Sonic Hedgehog signaling pathway

Small-molecule modulators of the Sonic Hedgehog signaling pathway

Small-molecule modulators of the Sonic Hedgehog signaling pathway Shh pathway inhibition with non-naturally occurring small molecules Cell-based assays with reporter gene constructs have been widely used for discovering non-naturally occurring […]

Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

The ADP-ribosyltranferase diphtheria toxin-like (ARTD) or poly-ADP-ribose polymerase (PARP) protein superfamily comprises 17 proteins that contain a common catalytic domain. Those that are catalytically active use β-NAD+ as an essential […]