BKM120 - CAS 944396-07-0
Catalog number: B0084-438224
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
BKM120, also called as buparlisib or NVP-BKM120, activity in a range of preclinical cancermodels, specifically inhbits class I PI3K isoforms, which blocks p110α (IC50 = 52 nM), p110β (IC50 = 166 nM), p110δ (IC50 = 116 nM) and p110γ (IC50 = 262 nM). And BKM120 displays little sensitive to Class III and Class IV PI3K's or PI4K.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-438224 200 mg $198 In stock
Bulk Inquiry
Publication citing BOC Sciences Products
  • >> More
Brife Description:
Specifically inhbits class I PI3K isoforms
White to off-white solid
5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine; BKM120; buparlisib; NVP-BKM120; 944396-07-0; BKM 120; BKM-120; UNII-0ZM2Z182GD; 1202777-78-3; 944396-07-0; NVP-BKM120; Buparlisib; 5-(2,6-dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine; NVP-BKM-120; BKM120; BKM 120; BKM-120; UNII-0ZM2Z182GD; 1202777-78-3; CHEMBL2017974; CHEBI:71954; 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine; 5-[2,6-Di(Morpholin-4-Yl)pyrimidin-4-Yl]-4-(Trifluoromethyl)pyridin-2-Amine; C18H21F3N6O2; BKM120, BKM-120|; 2-Pyridinamine,5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-; 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-Pyridinamine
Soluble to ≥80mg/mL in DMSO, to <1.2mg/mL in Water, to ≥22mg/mL in Ethanol
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -42℃ for long term (months to years).
Shelf Life:
2 years
Boiling Point:
645.7±65.0 °C | Condition: Press: 760 Torr
1.382±0.06 g/cm3
Canonical SMILES:
Current Developer:
Dana-Farber Cancer Institute; Emory University; Indiana University; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (Canada); National Cancer Institute (USA); Novartis; Novartis Oncology; Ohio State University; Paoli-Calmettes-institute; Sarah Cannon Research Institute; Stanford University; University Hospital Tubingen; University of California at San Francisco
Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors
Jordi Rodon, Irene BrañaLillian L Siu, Maja J De Jonge, Natasha Homji, David Mills, Emmanuelle Di Tomaso, Celine Sarr, Lucia Trandafir, Cristian Massacesi, Ferry Eskens, Johanna C Bendell. Investigational New Drugs, August 2014, Vol. 32, Issue 4, pp. 670–681
Observations of hyperglycemia are indicative of PI3K pathway inhibition in patients treated with buparlisib, and demonstrate a potential role for metabolites such as Cpeptide as pharmacodynamic biomarkers. The analysis of glucose metabolism biomarkers presented here further supports the observation that buparlisib inhibits the PI3K pathway and perturbs glucose metabolism; however, due to the heterogeneous patient population and the limited numbers of patients treated at dose levels other than the MTD, a clear relationship between these biomarkers and the dose of buparlisib administered or the degree of pathway inhibition, was not established. Further work is ongoing to establish the utility of biomarkers such as C-peptide, as indicators of PI3K inhibitor activity.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related PI3K Products

CAS 1431697-78-7 CAL-130 Hydrochloride

CAL-130 Hydrochloride
(CAS: 1431697-78-7)

In the absence of PTEN phosphatase tumor suppressor function, PI3Kγ or PI3Kδ alone can support leukemogenesis, whereas inactivation of both isoforms suppressed ...

copanlisib hydrochloride
(CAS: 1402152-13-9)

Copanlisib hydrochloride is a potent inhibitor of Class I phosphoinositide 3-kinase which showed a therapeutic effect on non-Hodgkin lymphoma. It was approved t...

CAS 938444-93-0 D 106669

D 106669
(CAS: 938444-93-0)

D 106669 is a potent and selective PI3K inhibitor.

CAS 1702816-75-8 PI3Kδ-IN-2

(CAS: 1702816-75-8)

PI3Kδ-IN-2 is a potent and selective inhibitor ofPI3Kδ (IC50= 6.4 M).

CAS 648449-76-7 AS-604850

(CAS: 648449-76-7)

AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for P...

CAS 117-39-5 Quercetin

(CAS: 117-39-5)

Quercetin is a flavonoid found in galangal and is used as an antitumor agent that induces apoptosis of cancer cells. It acts as a PI 3-kinase and protein kinase...

CAS 1246535-95-4 Desmethyl-VS-5584

(CAS: 1246535-95-4)

Desmethyl-VS-5584, a demethyl analogue of VS-5584, is a PI3K/mTOR kinase inhibitor for the treatment of cancer.

CAS 677297-51-7 TG100-115

(CAS: 677297-51-7)

TG100-115 is a potent and selective PI3K γ and -δ inhibitor (IC50 values of 83 and 235 nM, respectively) with no effect on PI3Kα or -β (IC50 values > 1 μM). As ...

CAS 1013098-90-2 PI3Kα/mTOR-IN-1

(CAS: 1013098-90-2)

PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR (Kis= 10.6 nM and 12.5 nM for mTOR and PI3Kα, respectively).

CAS 1282512-48-4 Taselisib

(CAS: 1282512-48-4)

Taselisib, also known as GDC0032 or RG7606, is a selective, potent, orally bioavailable inhibitor of PI3Ka with a Ki = 0.2nM, and with reduced inhibitory activi...

CAS 1172118-03-4 PI3Ky inhibitor 1

PI3Ky inhibitor 1
(CAS: 1172118-03-4)

PI3Ky inhibitor 1 is a potent PI3Ky inhibitor.

CAS 1349796-36-6 XL-765, SAR245409,

XL-765, SAR245409,
(CAS: 1349796-36-6)

CAS 371935-74-9 PI-103

(CAS: 371935-74-9)

PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α...

(CAS: 1282514-88-8)

GDC-0326 is a selective PI3Kα (α-Isoform of Phosphoinositide 3-Kinase) inhibitor. GDC-0326 is highly selective over other kinases. It has low plasma CL in human...

CAS 2060571-02-8 GDC-0077

(CAS: 2060571-02-8)

GDC-0077 is an orally available and selective PI3K inhibitor (IC50 = 0.038 + 0.003 nM) with > 300-fold selective over other Class I PI3K isoforms. GDC-0077 exer...

CAS 957209-68-6 NVP-QAV-572

(CAS: 957209-68-6)

NVP-QAV-572 is a potent PI3K kianse inhibitor.

CAS 677338-12-4 PIK-90

(CAS: 677338-12-4)

PIK-90 is a potent PI3K inhibitor.

CAS 5142-23-4 3-Methyladenine

(CAS: 5142-23-4)

3-Methyladenine is an autophagy inhibitor that protects cerebellar granule cells (CGCs) from apoptosis following serum/potassium deprivation. 3-Methyladenine in...

(CAS: 1338483-10-5)

AM-9635 is a selective Phosphatidylinositol-3-kinase delta (PI3Kδ) inhibitor. AM-9635 exhibits good cellular potency (in vitro pAKT IC50 = 4.2 nM ). AM-9635 can...

CAS 870281-34-8 Acalisib

(CAS: 870281-34-8)

Acalisib, also known as GS-9820,  is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) ...

Chemical Structure

CAS 944396-07-0 BKM120

Quick Inquiry

Verification code

Featured Items