Bitoscanate - CAS 4044-65-9
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Bitoscanate is an organic chemical compound used in the treatment of hookworms.
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off-white to yellow to beige-grey crystalline
1,4-Diisothiocyanatobenzene; 1,4-Phenylene diisothiocyanate;
Soluble in DMSO
Store at 2-8 °C
Used in the treatment of hookworms.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Melting Point:
132 °C
Canonical SMILES:
1.Development of an animal model of fibrous cholangitis in pigs.
Lainakis NG1, Papalois A, Agrogiannis G, Antonopoulos CN, Michail P, Bastounis E, Patsouris E, Felekouras E. J Invest Surg. 2014 Apr;27(2):95-101. doi: 10.3109/08941939.2013.839010. Epub 2014 Jan 10.
INTRODUCTION: The aim of this study was to develop a model of fibrous cholangitis in the offspring of gravid domestic pigs through the administration of 1,4-phenylene diisothiocyanate (DITC).
2.Label-free impedimetric immunosensor for ultrasensitive detection of cancer marker Murine double minute 2 in brain tissue.
Elshafey R1, Tlili C, Abulrob A, Tavares AC, Zourob M. Biosens Bioelectron. 2013 Jan 15;39(1):220-5. doi: 10.1016/j.bios.2012.07.049. Epub 2012 Aug 3.
The detection of cancer biomarkers is as important tool for the diagnosis and prognosis of cancer such as brain cancer. Murine double minute 2 (MDM2) has been widely studied as prognostic marker for brain tumor. Here we describe development of a new sensitive label free impedimetric immunosensor for the detection of MDM2 based on cysteamine self assembled monolayers on a clean polycrystalline Au electrode surface. The amine-modified electrodes were further functionalized with antibody using homobifunctional 1,4-phenylene diisothiocyanate (PDITC) linker. The assembly processes of the immunosensor had been monitored with cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques using Fe(CN)(6)(3-/4-) solution as redox probe. The impedance changes upon binding of MDM2 protein to the sensor surface was utilized for the detection of MDM2. The increase in relative electron-transfer resistance (ΔR/R(0)%) values was linearly proportional to the concentration of tumor marker MDM2 in the wide dynamic range of 1pg/ml-1μg/ml.
3.Cyclodextrin-modified zeolites: host-guest surface chemistry for the construction of multifunctional nanocontainers.
Szarpak-Jankowska A1, Burgess C, De Cola L, Huskens J. Chemistry. 2013 Oct 25;19(44):14925-30. doi: 10.1002/chem.201302153. Epub 2013 Sep 13.
The functionalization of nanoporous zeolite L crystals with β-cyclodextrin (CD) has been demonstrated. The zeolite surface was first modified with amino groups by using two different aminoalkoxysilanes. Then, 1,4-phenylene diisothiocyanate was reacted with the amino monolayer and used to bind CD heptamine by using its remaining isothiocyanate groups. The use of the different aminoalkoxysilanes, 3-aminopropyl dimethylethoxysilane (APDMES) and 3-aminopropyl triethoxysilane (APTES), led to drastic differences in uptake and release properties. Thionine was found to be absorbed and released from amino- and CD-functionalized zeolites when APDMES was used, whereas functionalization by APTES led to complete blockage of the zeolite channels. Fluorescence microscopy showed that the CD groups covalently attached to the zeolite crystals could bind adamantyl-modified dyes in a specific and reversible manner. This strategy allowed the specific immobilization of His-tagged proteins by using combined host-guest and His-tag-Ni-nitrilotriacetic acid (NTA) coordination chemistry.
4.Catalytic activity and thermostability of enzymes immobilized on silanized surface: influence of the crosslinking agent.
Aissaoui N1, Landoulsi J, Bergaoui L, Boujday S, Lambert JF. Enzyme Microb Technol. 2013 May 10;52(6-7):336-43. doi: 10.1016/j.enzmictec.2013.02.018. Epub 2013 Mar 13.
In this work, we investigate the influence of crosslinkers on the operational and heat stability of immobilized enzymes on a silanized silicon surface. To this end, glucose-6-phosphate dehydrogenase (G6PDH), a model multimeric enzyme, was attached through bifunctional crosslinkers able to bind covalently the -NH2 in the silane layer and of amine residues in the enzyme. Five bifunctional crosslinkers in the form of "X-spacer-X" were used, differing by the reactive functional groups (X=aldehyde: -CHO, isothiocyanate: -NCS, isocyanate: -NCO), by the nature of the spacer chain (aromatic or aliphatic) or by the geometry (bifunctional groups positioned in meta- or para- on an aromatic ring). A thermostability enhancement has been obtained for enzymes immobilized using 1,4-phenylene diisothiocyanate (PDC) and 1,4-phenylene diisocyanate (DIC). Moreover, using the latter crosslinker, activity was the mostly preserved upon successive uses, thus giving the best operational stability achieved.
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CAS 4044-65-9 Bitoscanate

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