Bithionol sulfoxide - CAS 844-26-8
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Not Intended for Therapeutic Use. For research use only.
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Bithionol sulfoxide is a clinically approved anti-parasitic drug. It has been shown to inhibit solid tumor growth in several preclinical cancer models.
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1.Mutagenicity of bithionol sulfoxide and its metabolites in the salmonella/mammalian microsome test.
Mourot D, Mourot A. Mutat Res. 1987 May;188(1):53-5.
The mutagenic effects of bithionol sulfoxide and its two major metabolites, bithionol and bithionol sulfone, on 4 Salmonella typhimurium strains (TA97, TA98, TA100 and TA102) were investigated. Bithionol sulfoxide was found to be mutagenic to TA98 and TA100. However, mutagenicity was abolished in the presence of rat-liver S9 fractions.
2.Liquid chromatographic determination of depletion of bithionol sulfoxide and its two major metabolites in bovine milk.
Mourot D1, Dagorn M, Delepine B. J Assoc Off Anal Chem. 1987 Sep-Oct;70(5):810-2.
A liquid chromatographic method is described for determining bithionol sulfoxide and its metabolites, bithionol and bithionol sulfone, in milk. Samples are treated with HCl to precipitate proteins and to permit extraction of bithionol sulfoxide in nonionized form. Tetrahydrofuran is added to the organic phase to facilitate extraction in diethyl ether; the dried residue is dissolved in chloroform, hexane, and sodium hydroxide and subjected to LC analysis. Residues of bithionol sulfoxide and its 2 metabolites were determined in milk of lactating cows. Holstein-Friesian dairy cows were administered a single oral dose of bithionol sulfoxide (50 mg/kg). Milk samples were analyzed with a reliable detection level of 0.025 microgram/mL for each compound. Residues of bithionol sulfoxide and bithionol were detected during 30 and 16 milkings, respectively; bithionol sulfone was never present at detectable levels.
3.Metabolic detoxication of bis-(2-hydroxy-3, 5-dichlorophenyl)-sulfoxide in man.
Sakamoto M, Chiba K, Agata I, Higa T, Kiyota M, Hayashi N, Yagi N, Itoh M, Sekikawa H, Takada M. J Toxicol Sci. 1981 Nov;6(4):307-14.
The metabolic detoxication of bis(2-hydroxy-3, 5-dichlorophenyl)sulfoxide (BTS) in man was investigated. Bis(2-hydroxy-3, 5-dichlorophenyl)sulfide (BT) was identified in beta-glucuronidase treated urine following the administration of BTS by thin-layer chromatography, gas chromatography, ultraviolet spectrum and quantitative analysis. No other metabolites were detectable. BT-glucuronide was also identified in urine. It was assumed that BTS was reduced to BT and successively conjugated with glucuronide in man, and excreted as BT-glucuronide in the urine.
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CAS 844-26-8 Bithionol sulfoxide

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