1.Bisoprolol pharmacokinetics and body composition in patients with chronic heart failure: a longitudinal study.
Cvan Trobec K1, Grabnar I1, Kerec Kos M1, Vovk T1, Trontelj J1, Anker SD2, Rosano G3,4, Lainscak M5,6. Eur J Clin Pharmacol. 2016 Mar 21. [Epub ahead of print]
PURPOSE: We investigated bisoprolol pharmacokinetics, including longitudinal changes and importance of patient characteristics in chronic heart failure.
2.Beneficial effect on surrogate markers of heart failure with bisoprolol up-titration to recommended targets in Korean patients with heart failure and left ventricular systolic dysfunction.
Han SW1, Choi SW1, Ryu KH1, Kim HJ2, Kim SH2, Shim WJ3, Cha TJ4, Choi DJ5, Kim YJ6, Yoo BS7, Jun-HyungKim8, Hwang KK9, Jeon H10, Shin MS11. Cardiovasc Ther. 2016 Mar 22. doi: 10.1111/1755-5922.12185. [Epub ahead of print]
INTRODUCTION: The objective of this study was to establish the benefit of bisoprolol up-titration toward recommended dosage targets, versus lower-dose maintenance, in heart failure (HF) patients with systolic dysfunction.
3.β1-Adrenergic blocker bisoprolol reverses down-regulated ion channels in sinoatrial node of heart failure rats.
Du Y1, Zhang J1, Xi Y2, Wu G1, Han K1, Huang X1, Ma A1,3,4, Wang T5,6,7. J Physiol Biochem. 2016 Mar 19. [Epub ahead of print]
Bisoprolol, an antagonist of β1-adrenergic receptors, is effective in reducing the morbidity and mortality in patients with heart failure (HF). It has been found that HF is accompanied with dysfunction of the sinoatrial node (SAN). However, whether bisoprolol reverses the decreased SAN function in HF and how the relevant ion channels in SAN change were relatively less studied. SAN function and messenger RNA (mRNA) expression of sodium channels and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel subunits were assessed in sham-operated rats, abdominal arterio-venous shunt (volume overload)-induced HF rats, and bisoprolol- treated HF rats. SAN cells of rats were isolated by laser capture microdissection. Quantitative real-time PCR analysis was used to quantify mRNA expression of sodium channels and HCN channel subunits in SAN. Intrinsic heart rate declined and sinus node recovery time prolonged in HF rats, indicating the suppressed SAN function, which could be improved by bisoprolol treatment.