Bisacodyl - CAS 603-50-9
Catalog number:
603-50-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H19NO4
Molecular Weight:
361.39
COA:
Inquire
Targets:
Others
Description:
Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.Bisacodyl works by stimulating enteric nerves to cause colonic contractions.
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Purity:
>98%
MSDS:
Inquire
1.Objective and Subjective Intrapatient Comparison of Iohexol Versus Diatrizoate for Bowel Preparation Quality at CT Colonography.
Johnson B1, Hinshaw JL1, Robbins JB1, Pickhardt PJ1. AJR Am J Roentgenol. 2016 Mar 24:1-6. [Epub ahead of print]
OBJECTIVE: The purpose of this study is to objectively and subjectively compare nonionic iohexol and ionic diatrizoate iodinated oral contrast agents as part of a cathartic bowel regimen within the same CT colonography (CTC) cohort, with otherwise identical preparations.
2.Polyethylene glycol plus ascorbic acid is as effective as sodium picosulfate with magnesium citrate for bowel preparation : randomized trial.
Choi HS1, Chung JW1, Lee JW, Lim MY, Park DK1, Kim YJ1, Kwon KA1, Kim JH1. J Dig Dis. 2016 Mar 6. doi: 10.1111/1751-2980.12337. [Epub ahead of print]
BACKGROUND AND AIM: Optimal colon cleansing is essential for the efficacy and safety of endoscopic evaluation of the colon. However, consumption of large volumes of bowel preparation agent, along with its bad taste and potential adverse effects often prevent patients from receiving an ideal colonoscopy. We evaluated the efficacy and safety of two low- volume agents for bowel preparation.
3.Comparison between different colon cleansing products for screening colonoscopy. A noninferiority trial in population-based screening programs in Italy.
Zorzi M1, Valiante F2, Germanà B3, Baldassarre G4, Coria B5, Rinaldi M6, Heras Salvat H7, Carta A8, Bortoluzzi F9, Cervellin E10, Polo ML11, Bulighin G12, Azzurro M13, Di Piramo D14, Turrin A15, Monica F16; TriVeP Working Group. Endoscopy. 2016 Mar;48(3):223-31. doi: 10.1055/s-0035-1569574. Epub 2016 Jan 13.
BACKGROUND AND STUDY AIMS: The high volume and poor palatability of 4 L of polyethylene glycol (PEG)-based bowel cleansing preparation required before a colonoscopy represent a major obstacle for patients. The aim of this study was to compare two low volume PEG-based preparations with standard 4 L PEG in individuals with a positive fecal immunochemical test (FIT) within organized screening programs in Italy.
4.Desacetyl bisacodyl-induced epithelial Cl(-) secretion in rat colon and rectum.
Fujita T1, Karaki S, Tateoka T, Kuwahara A. Biomed Res. 2016;37(1):13-20. doi: 10.2220/biomedres.37.13.
The purpose of this study was to clarify the mode of desacetyl bisacodyl (DAB)-induced secretory action in intestinal tissues using an Ussing chamber assay. DAB is the active metabolite of the laxative bisacodyl. In mucosal-submucosal preparations, mucosal application of DAB induced a transient decrease followed by subsequent increases in short-circuit current and tissue conductance in a concentration-dependent manner. DAB-induced responses occurred from the middle colon to the rectal segment but not in the proximal colon. Moreover, these responses were not observed under chloride (Cl(-))-free conditions or in the presence of DAB on the serosal side of the mucosalsubmucosal specimens. Treatment with tetrodotoxin had no effect on the DAB-induced responses; however, mucosal treatment with a COX inhibitor piroxicam resulted in the elimination of responses. These results suggest that DAB may contribute to the laxative action by inducing Cl(-) secretion which is associated with the COX signaling pathway.
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CAS 603-50-9 Bisacodyl

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