Biperiden Hydrochloride - CAS 1235-82-1
Catalog number:
1235-82-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H30ClNO
Molecular Weight:
347.92
COA:
Inquire
Targets:
mAChR
Description:
Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. Biperiden is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Akineton hydrochloride; NSC 170950; NSC 84989
MSDS:
Inquire
1.Acute dystonic reaction due to dexketoprofen trometamol.
Kayipmaz AE1, Giray TA1, Tasci SS1, Tasci SS1, Kavalci C1, Kocalar UG1. J Pak Med Assoc. 2015 Nov;65(11):1231-2.
Dexketoprofentrometamol (DKP), is a tromethamine salt of the water-soluble S-enantiomer of ketoprofen. As with all other non-steroidal anti-inflammatory agents, the most common side effect of DKP is gastric complications. In this paper, we report a case of dystonic reaction after intravenous DKP use. A 24-year-old man was admitted to our hospital after suffering a leg burn from boiling oil. He had no drug hypersensitivity. An intravenous preparation containing the active ingredient DKP was injected for analgesia, after which the patient experienced an involuntary flexion response in both upper extremities. With a suspected diagnosis of dystonia, biperiden lactate 5 mg/ml was administered via the intramuscular route and the contractions abated within 30 seconds of the injection.As non-steroidal anti-inflammatory agents are commonly used and prescribed in emergency departments, it should be kept in mind that an acute dystonic reaction can develop against one of these agents, DKP.
2.Acetylcholine mediates behavioral and neural post-error control.
Danielmeier C1, Allen EA2, Jocham G3, Onur OA4, Eichele T2, Ullsperger M5. Curr Biol. 2015 Jun 1;25(11):1461-8. doi: 10.1016/j.cub.2015.04.022. Epub 2015 May 7.
Humans often commit errors when they are distracted by irrelevant information and no longer focus on what is relevant to the task at hand. Adjustments following errors are essential for optimizing goal achievement. The posterior medial frontal cortex (pMFC), a key area for monitoring errors, has been shown to trigger such post-error adjustments by modulating activity in visual cortical areas. However, the mechanisms by which pMFC controls sensory cortices are unknown. We provide evidence for a mechanism based on pMFC-induced recruitment of cholinergic projections to task-relevant sensory areas. Using fMRI in healthy volunteers, we found that error-related pMFC activity predicted subsequent adjustments in task-relevant visual brain areas. In particular, following an error, activity increased in those visual cortical areas involved in processing task-relevant stimulus features, whereas activity decreased in areas representing irrelevant, distracting features.
3.Biperiden selectively induces memory impairment in healthy volunteers: no interaction with citalopram.
Sambeth A1, Riedel WJ, Klinkenberg I, Kähkönen S, Blokland A. Psychopharmacology (Berl). 2015 Jun;232(11):1887-97. doi: 10.1007/s00213-014-3822-9. Epub 2014 Dec 4.
RATIONALE: Traditionally, the non-selective muscarinic antagonist scopolamine has been used to induce episodic memory impairments as found in Alzheimer's disease (AD). However, it also impairs attention and induces drowsiness. Muscarinic antagonists more selective for the M1 receptor might, therefore, be preferred.
4.Effects of Shakuyaku-Kanzo-to on Extrapyramidal Symptoms During Antipsychotic Treatment: A Randomized, Open-Label Study.
Ota T1, Miura I, Kanno-Nozaki K, Hoshino H, Horikoshi S, Fujimori H, Kanno T, Mashiko H, Yabe H. J Clin Psychopharmacol. 2015 Jun;35(3):304-7. doi: 10.1097/JCP.0000000000000312.
Extrapyramidal symptoms (EPS) are common adverse effects of antipsychotic treatment. This study examined the effects of the traditional Japanese herbal medicine (kampo) shakuyaku-kanzo-to on EPS during antipsychotic treatment. Twenty-two Japanese patients with psychiatric disorders who had developed EPS during antipsychotic treatment were randomly allocated to receive either shakuyaku-kanzo-to (7.5 g/d) or biperiden (3 mg/d) for 2 weeks. Extrapyramidal symptoms were evaluated using the Drug-Induced Extrapyramidal Symptom Scale (DIEPSS) and the Barnes Akathisia Rating Scale. Plasma levels of the monoamine metabolite homovanillic acid and serum prolactin levels were measured to investigate the mechanisms of action of shakuyaku-kanzo-to. Twenty of the 22 patients completed the study (10 patients in the shakuyaku-kanzo-to group and 10 patients in the biperiden group). There was a time effect on the Drug-Induced Extrapyramidal Symptom Scale total score (P < 0.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related mAChR Products


CAS 50-34-0 Propantheline Bromide

Propantheline Bromide
(CAS: 50-34-0)

Propantheline Bromide is an antimuscarinic agent used as an antispasmodic for the treatment of ulcers.

CAS 51-56-9 Homatropine Bromide

Homatropine Bromide
(CAS: 51-56-9)

Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 1...

CAS 5633-20-5 Oxybutynin

Oxybutynin
(CAS: 5633-20-5)

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.

CAS 124937-51-5 (R)-(+)-Tolterodine

(R)-(+)-Tolterodine
(CAS: 124937-51-5)

A muscarinic receptor antagonist. Used in the treatment of urinary incontinence.

CAS 242478-38-2 Solifenacin succinate

Solifenacin succinate
(CAS: 242478-38-2)

Solifenacin is a competitive cholinergic receptor antagonist.Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.

CAS 1135242-13-5 VU 0357017 hydrochloride

VU 0357017 hydrochloride
(CAS: 1135242-13-5)

The hydrochloride salt form of VU0357017 which is a selective M1 agonists and has been found to be probably effective in the treatment of hippocampal-dependent ...

CAS 155-41-9 Methscopolamine

Methscopolamine
(CAS: 155-41-9)

Methscopolamine is a muscarinic acetylcholine receptor blocker.

CAS 136310-93-5 Tiotropium bromide

Tiotropium bromide
(CAS: 136310-93-5)

Tiotropium Bromide, an azoniatricyclo derivative, is a mAChR antagonist that could be used as bronchodilation agent and smooth muscle relaxant.

CAS 107220-28-0 Cevimeline hydrochloride

Cevimeline hydrochloride
(CAS: 107220-28-0)

Cevimeline hydrochloride is a selective M1 receptor agonist.

CAS 96487-37-5 Nuvenzepine

Nuvenzepine
(CAS: 96487-37-5)

Nuvenzepine, a new pirenzepine-analog, is an mAChR antagonist, administered intraduodenally, displayed a long-lasting and dose-dependent inhibition of neostigmi...

CAS 141064-23-5 Xanomeline oxalate

Xanomeline oxalate
(CAS: 141064-23-5)

Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Xanomeline oxalate is a potent agonist of muscarinic acetylcholine r...

CAS 5633-14-7 Benzetimide hydrochloride

Benzetimide hydrochloride
(CAS: 5633-14-7)

Benzetimide hydrochloride is a muscarinic acetylcholine receptor antagonist that has anticholinergic properties and could block pilocarpine-induced lacrimation.

CAS 62-97-5 Diphemanil Methylsulfate

Diphemanil Methylsulfate
(CAS: 62-97-5)

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic.It binds muscarinic acetycholine receptors (mAchR).

CAS 3485-62-9 Clidinium Bromide

Clidinium Bromide
(CAS: 3485-62-9)

Clidinium bromide is an anticholinergic used as an antispasmodic to reduce stomach acid and decreases intestinal spasms.

CAS 22254-24-6 Ipratropium bromide

Ipratropium bromide
(CAS: 22254-24-6)

Ipratropium bromide, under the trade name Atrovent, structurally similar to atropine, is a muscarinic antagonist and a bronchodilator.

CAS 57381-26-7 Irsogladine

Irsogladine
(CAS: 57381-26-7)

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reductio...

CAS 10049-83-9 Pyrithioxin dihydrochloride

Pyrithioxin dihydrochloride
(CAS: 10049-83-9)

Pyrithioxin dihydrochloride, a pyridine thiol derivative, is a nootropic which could be used in the treatment of sequelae of brain trauma, encephalitis and meni...

CAS 146422-58-4 CDD0102

CDD0102
(CAS: 146422-58-4)

CDD0102 is a selective M1 agonist which stimulated the secretion of APP from CHO-K1 cells expressing M1 receptors and penetrated into the brain following i.p. a...

CAS 62-51-1 Methacholine chloride

Methacholine chloride
(CAS: 62-51-1)

Methacholine chloride, a synthetic choline ester, is pharmaceutical agent acting as a β2-adrenergic agonist used in the treatment of pulmonary and respiratory d...

CAS 409351-28-6 VU0152100

VU0152100
(CAS: 409351-28-6)

VU0152100 is a selective and positive allosteric modulators of M4 receptor. It has shown a potent positive allosteric modulators that increase the response of t...

Chemical Structure

CAS 1235-82-1 Biperiden Hydrochloride

Quick Inquiry

Verification code

Featured Items