Biperiden Hydrochloride - CAS 1235-82-1
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Not Intended for Therapeutic Use. For research use only.
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Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. Biperiden is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy.
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Akineton hydrochloride; NSC 170950; NSC 84989
1.Acute dystonic reaction due to dexketoprofen trometamol.
Kayipmaz AE1, Giray TA1, Tasci SS1, Tasci SS1, Kavalci C1, Kocalar UG1. J Pak Med Assoc. 2015 Nov;65(11):1231-2.
Dexketoprofentrometamol (DKP), is a tromethamine salt of the water-soluble S-enantiomer of ketoprofen. As with all other non-steroidal anti-inflammatory agents, the most common side effect of DKP is gastric complications. In this paper, we report a case of dystonic reaction after intravenous DKP use. A 24-year-old man was admitted to our hospital after suffering a leg burn from boiling oil. He had no drug hypersensitivity. An intravenous preparation containing the active ingredient DKP was injected for analgesia, after which the patient experienced an involuntary flexion response in both upper extremities. With a suspected diagnosis of dystonia, biperiden lactate 5 mg/ml was administered via the intramuscular route and the contractions abated within 30 seconds of the injection.As non-steroidal anti-inflammatory agents are commonly used and prescribed in emergency departments, it should be kept in mind that an acute dystonic reaction can develop against one of these agents, DKP.
2.Acetylcholine mediates behavioral and neural post-error control.
Danielmeier C1, Allen EA2, Jocham G3, Onur OA4, Eichele T2, Ullsperger M5. Curr Biol. 2015 Jun 1;25(11):1461-8. doi: 10.1016/j.cub.2015.04.022. Epub 2015 May 7.
Humans often commit errors when they are distracted by irrelevant information and no longer focus on what is relevant to the task at hand. Adjustments following errors are essential for optimizing goal achievement. The posterior medial frontal cortex (pMFC), a key area for monitoring errors, has been shown to trigger such post-error adjustments by modulating activity in visual cortical areas. However, the mechanisms by which pMFC controls sensory cortices are unknown. We provide evidence for a mechanism based on pMFC-induced recruitment of cholinergic projections to task-relevant sensory areas. Using fMRI in healthy volunteers, we found that error-related pMFC activity predicted subsequent adjustments in task-relevant visual brain areas. In particular, following an error, activity increased in those visual cortical areas involved in processing task-relevant stimulus features, whereas activity decreased in areas representing irrelevant, distracting features.
3.Biperiden selectively induces memory impairment in healthy volunteers: no interaction with citalopram.
Sambeth A1, Riedel WJ, Klinkenberg I, Kähkönen S, Blokland A. Psychopharmacology (Berl). 2015 Jun;232(11):1887-97. doi: 10.1007/s00213-014-3822-9. Epub 2014 Dec 4.
RATIONALE: Traditionally, the non-selective muscarinic antagonist scopolamine has been used to induce episodic memory impairments as found in Alzheimer's disease (AD). However, it also impairs attention and induces drowsiness. Muscarinic antagonists more selective for the M1 receptor might, therefore, be preferred.
4.Effects of Shakuyaku-Kanzo-to on Extrapyramidal Symptoms During Antipsychotic Treatment: A Randomized, Open-Label Study.
Ota T1, Miura I, Kanno-Nozaki K, Hoshino H, Horikoshi S, Fujimori H, Kanno T, Mashiko H, Yabe H. J Clin Psychopharmacol. 2015 Jun;35(3):304-7. doi: 10.1097/JCP.0000000000000312.
Extrapyramidal symptoms (EPS) are common adverse effects of antipsychotic treatment. This study examined the effects of the traditional Japanese herbal medicine (kampo) shakuyaku-kanzo-to on EPS during antipsychotic treatment. Twenty-two Japanese patients with psychiatric disorders who had developed EPS during antipsychotic treatment were randomly allocated to receive either shakuyaku-kanzo-to (7.5 g/d) or biperiden (3 mg/d) for 2 weeks. Extrapyramidal symptoms were evaluated using the Drug-Induced Extrapyramidal Symptom Scale (DIEPSS) and the Barnes Akathisia Rating Scale. Plasma levels of the monoamine metabolite homovanillic acid and serum prolactin levels were measured to investigate the mechanisms of action of shakuyaku-kanzo-to. Twenty of the 22 patients completed the study (10 patients in the shakuyaku-kanzo-to group and 10 patients in the biperiden group). There was a time effect on the Drug-Induced Extrapyramidal Symptom Scale total score (P < 0.
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CAS 1235-82-1 Biperiden Hydrochloride

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